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Bessis D.,Montpellier University Hospital Center | Kempf M.,Institute Of Biologie En Sante | Kempf M.,University of Angers | Marsollier L.,University of Angers | Marsollier L.,Angers University Hospital Center
Acta Dermato-Venereologica | Year: 2015

Buruli ulcer (BU) is a necrotizing skin and soft tissue infection caused by Mycobacterium ulcerans. This tropical disease has been relatively neglected up to now, but it is the third most common chronic mycobacterial infection in humans, with cases reported from more than 30 countries. The highest incidence rate is observed in sub-Saharan Africa, but, to date, Mali has not been cited as an endemic country (1, 2). We report here a case of BU in a young girl living in Bamako, Mali. To our knowledge, this is the second case reported in this country (3). © 2015 The Authors.

Soleti R.,French Institute of Health and Medical Research | Andriantsitohaina R.,French Institute of Health and Medical Research | Andriantsitohaina R.,University of Angers | Martinez M.C.,French Institute of Health and Medical Research | Martinez M.C.,Institute Of Biologie En Sante
Topics in Medicinal Chemistry | Year: 2015

New vessel formation plays a key role not only in physiological processes such as embryonic development and wound repair but also during several pathological situations. In this respect, favoring neovascularization represents a promising therapeutic approach that would allow inducing tissue repair. Among the candidate proteins able to modulate neovascularization, evidence show that the administration of recombinant hedgehog (Hh) protein, gene, or cell therapy based on Hh transfer or using extracellular vesicles as vectors enhance new vessel formation. Here, we summarized the role of Hh pathway on angiogenesis and its therapeutic potential during myocardial infarction and diabetes. © Springer-Verlag Berlin Heidelberg 2014.

De Gentile L.,Institute Of Biologie En Sante | Verdier S.,University of Angers | Grosbois M.,University of Angers
Revue Francophone des Laboratoires | Year: 2013

Works in Healthcare facilities are a necessity both for the development of these structures, their maintenance and upkeep of local qualified to care. However, their implementation is hampered by the requirement to maintain a care activity. These works can generate a risk for patients linked to the spread of dust and suspension of fungal spores. This risk assessment must be integrated into the project of works, well ahead of their realization. Its evaluation should be done by a multidisciplinary team combining infection control practionner, mycologist and construction management. © 2013 Elsevier Masson SAS Tous droits réservés.

Jacques C.,Institute National Of La Sante | Jacques C.,University of Angers | Guillotin D.,Institute National Of La Sante | Guillotin D.,University of Angers | And 14 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2013

Context: Focusing on mitochondrial function and thyroid tumorigenesis, we used an integrative approach to identify relevant biomarkers for borderline thyroid lesions. Design: Using cDNA and microRNA (miRNA) microarrays and quantitative RT-PCR analysis (qPCR), we explored samples of various types of thyroid tumors including 25 benign follicular adenomas represented by macrofollicular variants of thyroid adenomas, 38 oncocytic variants of follicular thyroid tumors, 19 papillary thyroid carcinomas, and 10 tumors of uncertain malignant potential, together with 53 normal thyroid tissue samples. Results: Our transcriptomic analysis, which highlighted discrepancies between controls and tumor tissues, as well as between various tumor types, led to the identification of 13 genes, allowing discrimination between the thyroid adenomas, oncocytic variants of follicular thyroid tumors, and papillary thyroid carcinomas, whereas the tumors of uncertain malignant potential were found to overlap these classes. Five of these genes (TP53, HOXA9, RUNX1, MYD88, and CITED1), with a differential expression confirmed by qPCR analysis, are implicated in tumorigenesis, 4 in mitochondrial metabolism (MRPL14, MRPS2, MRPS28, and COX6A1), and 2 in thyroid metabolic pathways (CaMKIINalpha and TPO). The global miRNA analysis revealed 62 differential miRNAs, the expression level for 10 of these being confirmed by qPCR. The differential expression of the miRNAs was in accordance with the modulation of gene expression and the ontologies revealed by our transcriptomic analysis. Conclusions: These findings reinforce the classification of follicular thyroid tumors established by the World Health Organization, and our technique offers a novel molecular approach to refine the classification of thyroid tumors of uncertain malignant potential. Copyright © 2013 by The Endocrine Society.

Mabilleau G.,Institute Of Biologie En Sante | Mabilleau G.,Institut Universitaire de France | Chappard D.,Institute Of Biologie En Sante | Chappard D.,Institut Universitaire de France | And 2 more authors.
Expert Review of Endocrinology and Metabolism | Year: 2015

An increased fracture risk is observed in Type 1 and Type 2 diabetic patients. Although diabetes-related complications are important in the etiology of bone fracture in diabetes, the effect of anti-diabetic medications should not be neglected. Indeed, many drugs used commonly to treat diabetes can interfere with bone physiology, resulting in a positive or negative impact on skeletal health. The aim of the present review is to summarize the current evidence on the effects of anti-diabetic drugs on bone. © 2015 Taylor and Francis.

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