Institute Of Biologie En Sante

Mons-en-Pévèle, France

Institute Of Biologie En Sante

Mons-en-Pévèle, France

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Bessis D.,Montpellier University Hospital Center | Kempf M.,Institute Of Biologie En Sante | Kempf M.,University of Angers | Marsollier L.,University of Angers | Marsollier L.,Angers University Hospital Center
Acta Dermato-Venereologica | Year: 2015

Buruli ulcer (BU) is a necrotizing skin and soft tissue infection caused by Mycobacterium ulcerans. This tropical disease has been relatively neglected up to now, but it is the third most common chronic mycobacterial infection in humans, with cases reported from more than 30 countries. The highest incidence rate is observed in sub-Saharan Africa, but, to date, Mali has not been cited as an endemic country (1, 2). We report here a case of BU in a young girl living in Bamako, Mali. To our knowledge, this is the second case reported in this country (3). © 2015 The Authors.


De Gentile L.,Institute Of Biologie En Sante | Verdier S.,University of Angers | Grosbois M.,University of Angers
Revue Francophone des Laboratoires | Year: 2013

Works in Healthcare facilities are a necessity both for the development of these structures, their maintenance and upkeep of local qualified to care. However, their implementation is hampered by the requirement to maintain a care activity. These works can generate a risk for patients linked to the spread of dust and suspension of fungal spores. This risk assessment must be integrated into the project of works, well ahead of their realization. Its evaluation should be done by a multidisciplinary team combining infection control practionner, mycologist and construction management. © 2013 Elsevier Masson SAS Tous droits réservés.


Soleti R.,French Institute of Health and Medical Research | Andriantsitohaina R.,French Institute of Health and Medical Research | Andriantsitohaina R.,University of Angers | Martinez M.C.,French Institute of Health and Medical Research | Martinez M.C.,Institute Of Biologie En Sante
Topics in Medicinal Chemistry | Year: 2015

New vessel formation plays a key role not only in physiological processes such as embryonic development and wound repair but also during several pathological situations. In this respect, favoring neovascularization represents a promising therapeutic approach that would allow inducing tissue repair. Among the candidate proteins able to modulate neovascularization, evidence show that the administration of recombinant hedgehog (Hh) protein, gene, or cell therapy based on Hh transfer or using extracellular vesicles as vectors enhance new vessel formation. Here, we summarized the role of Hh pathway on angiogenesis and its therapeutic potential during myocardial infarction and diabetes. © Springer-Verlag Berlin Heidelberg 2014.


George A.,Angers University Hospital Center | Lefebvre-Lacoeuille C.,Angers University Hospital Center | Lefebvre-Lacoeuille C.,Institute Of Biologie En Sante | Lacoeuille F.,Angers University Hospital Center | And 8 more authors.
Medecine Nucleaire | Year: 2014

Objectives: Positron emission tomography with 16α-[18F]fluoro- 17β-œstradiol (PET-[18F]FES) is used to evaluate the in vivo tissue density in estrogen receptor (ER). We report here the first cases in the diagnosis of endometriosis. Patients and methods: Four patients with clinical and morphological signs (pelvic ultrasound±MRI) consistent with endometriosis were enrolled in this National Grant PHRC ENDOTEP. They underwent a PET-[18F]FES scan before laparoscopy (macroscopic and histological analysis, immuno-histochemical ER expression). Results: In the four patients, the diagnosis of endometriosis was confirmed on the typical macroscopic appearance of laparoscopy plus histological analysis of at least one lesion. No uptake of [18F]FES by endometriosis lesions was observed in the first three patients with estrogen-progestin therapy. The fourth patient, untreated and in the first part of the menstrual cycle when performing PET-[18F]FES, had however an increased [18F]FES uptake of one lesion of endometriosis confirmed by laparoscopy. Conclusion: We report here the first case of [18F]FES uptake by an endometriosis lesion. With the ENDOTEP trial, the performance of PET-[18F]FES for the diagnosis of endometriosis will be evaluated in patients who are not receiving hormone therapy. © 2014 Elsevier Masson SAS.


Mabilleau G.,Institute Of Biologie En Sante | Mabilleau G.,Institut Universitaire de France | Chappard D.,Institute Of Biologie En Sante | Chappard D.,Institut Universitaire de France | And 2 more authors.
Expert Review of Endocrinology and Metabolism | Year: 2015

An increased fracture risk is observed in Type 1 and Type 2 diabetic patients. Although diabetes-related complications are important in the etiology of bone fracture in diabetes, the effect of anti-diabetic medications should not be neglected. Indeed, many drugs used commonly to treat diabetes can interfere with bone physiology, resulting in a positive or negative impact on skeletal health. The aim of the present review is to summarize the current evidence on the effects of anti-diabetic drugs on bone. © 2015 Taylor and Francis.

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