Institute of Bioinformatics and Systems Biology and

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PubMed | Institute of Bioinformatics and Systems Biology and and Institute of Epidemiology II
Type: Journal Article | Journal: International journal of epidemiology | Year: 2016

Short-term exposure to air pollution is associated with morbidity and mortality. Metabolites are intermediaries in biochemical processes, and associations between air pollution and metabolites can yield unique mechanistic insights.We used independent cross-sectional samples with targeted metabolomics (138 metabolites across five metabolite classes) from three cohort studies, each a part of the Cooperative Health Research in the Region of Augsburg (KORA). The KORA cohorts are numbered (1 to 4) according to which survey they belong to, and lettered S or F according to whether the survey was a baseline or follow-up survey. KORA F4 (N=3044) served as our discovery cohort, with KORA S4 (N=485) serving as the primary replication cohort. KORA F4 and KORA S4 were primarily fasting cohorts. We used the non-fasting KORA F3 (N=377) cohort to evaluate replicated associations in non-fasting individuals, and we performed a random effects meta-analysis of all three cohorts. Associations between the 0-4-day lags and the 5-day average of particulate matter (PM)There were 10 discovery cohort associations, of which seven were lysophosphatidylcholines (LPCs); NOLPCs are associated with short-term exposure to air pollutants, in particular NO

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