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Hauser C.A.E.,Institute Of Bioengineering And Nanotechnology, Singapore | Maurer-Stroh S.,Agency for Science, Technology and Research Singapore | Martins I.C.,University of Lisbon
Chemical Society Reviews | Year: 2014

Self-assembling amyloid-like peptides and proteins give rise to promising biomaterials with potential applications in many fields. Amyloid structures are formed by the process of molecular recognition and self-assembly, wherein a peptide or protein monomer spontaneously self-associates into dimers and oligomers and subsequently into supramolecular aggregates, finally resulting in condensed fibrils. Mature amyloid fibrils possess a quasi-crystalline structure featuring a characteristic fiber diffraction pattern and have well-defined properties, in contrast to many amorphous protein aggregates that arise when proteins misfold. Core sequences of four to seven amino acids have been identified within natural amyloid proteins. They are capable to form amyloid fibers and fibrils and have been used as amyloid model structures, simplifying the investigations on amyloid structures due to their small size. Recent studies have highlighted the use of self-assembled amyloid-based fibers as nanomaterials. Here, we discuss the latest advances and the major challenges in developing amyloids for future applications in nanotechnology and nanomedicine, with the focus on development of sensors to study protein-ligand interactions. This journal is © the Partner Organisations 2014. Source

Kang C.,Agency for Science, Technology and Research Singapore | Li Q.,Institute Of Bioengineering And Nanotechnology, Singapore
Current Opinion in Chemical Biology | Year: 2011

Signals between a cell and its environment are often transmitted through membrane proteins; therefore, many membrane proteins, including G protein-coupled receptors (GPCRs) and ion channels, are important drug targets. Structural information about membrane proteins remains limited owing to challenges in protein expression, purification and the selection of membrane-mimicking systems that will retain protein structure and function. This review describes recent advances in solution NMR applied to the structural study of integral membrane proteins. The examples herein demonstrate that solution NMR spectroscopy will play a unique role not only in structural analysis, but also drug discovery of membrane proteins. © 2011 Elsevier Ltd. Source

Hauser C.A.E.,Institute Of Bioengineering And Nanotechnology, Singapore | Zhang S.,Institute Of Bioengineering And Nanotechnology, Singapore | Zhang S.,Massachusetts Institute of Technology
Chemical Society Reviews | Year: 2010

Scientists and bioengineers have dreamed of designing materials from the bottom up with the finest detail and ultimate control at the single molecular level. The discovery of a class of self-assembling peptides that spontaneously undergo self-organization into well-ordered structures opened a new avenue for molecular fabrication of biological materials. Since this discovery, diverse classes of short peptides have been invented with broad applications, including 3D tissue cell culture, reparative and regenerative medicine, tissue engineering, slow drug release and medical device development. Molecular design of new materials using short peptides is poised to become increasingly important in biomedical research, biomedical technology and medicine, and is covered in this tutorial review. © 2010 The Royal Society of Chemistry. Source

Riduan S.N.,Institute Of Bioengineering And Nanotechnology, Singapore | Zhang Y.,Institute Of Bioengineering And Nanotechnology, Singapore
Chemical Society Reviews | Year: 2013

Imidazolium salts, distinct from their parent imidazoles, are made up of a discrete cation and anion pair, and have found widespread utility as ionic liquids. A lesser known function of such imidazolium salts includes the application of these salts in biological systems, and several areas of bio-applications, including antitumour, antimicrobial, antioxidant and bioengineering applications, will be presented and discussed in this review. The wide-ranging applications and versatility of these imidazolium salts stem from the ease of their structural variation, in which properties such as amphiphilicity, lipophilicity and solubility can be tuned. This journal is © The Royal Society of Chemistry. Source

Gu L.,Institute Of Bioengineering And Nanotechnology, Singapore | Zhang Y.,Institute Of Bioengineering And Nanotechnology, Singapore
Journal of the American Chemical Society | Year: 2010

(Chemical Equation Presented) The catalytic reduction of carbon dioxide to carbon monoxide under mild conditions using aromatic aldehydes as reductants and NHCs as organocatalysts was developed. This carbon dioxide splitting reaction provides a new method for metal-free carbon dioxide reduction and steps forward in utilizing carbon dioxide as a renewable "green" source under mild conditions. On the other hand, this reaction also shows a new economical way to oxidize aromatic aldehydes under mild conditions with carbon dioxide and could be applied in pharmaceutical synthesis. © 2010 American Chemical Society. Source

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