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Zverinsky I.V.,Institute of Biochemistry of Biologically Active Compounds NASB | Zverinskaya N.G.,Institute of Biochemistry of Biologically Active Compounds NASB | Sutsko I.P.,Institute of Biochemistry of Biologically Active Compounds NASB | Telegin P.G.,Institute of Biochemistry of Biologically Active Compounds NASB | Shlyahtun A.G.,Institute of Biochemistry of Biologically Active Compounds NASB
Biomeditsinskaya Khimiya | Year: 2015

We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.


PubMed | Institute of Biochemistry of Biologically Active Compounds NASB
Type: Journal Article | Journal: Biomeditsinskaia khimiia | Year: 2015

We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.

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