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Guo L.,Qinghai University | Li X.,Institute of Basic Medicine | Guo Z.,Qinghai University
Journal of Materials Science: Materials in Electronics | Year: 2015

Novel nonlinear optical chromophore with strong electron donor, diazo electron bridge and isolation groups on both sides were synthesized and characterized by mass spectrum and hydrogen nuclear magnetic resonance. Strong electron donor and diazo electron bridge improve the nonlinear optical activities of the chromophore, large and reactive isolated groups improve the chromophore’s solubility and reduced the interaction among the chromophores. Second order nonlinear optical polymers with different chromophore loading densities were prepared and showed us the smallest glass transition temperature change. Large second order nonlinear optical coefficients were also gotten by second harmonic generation method 15.3, 27.2 and 33.4 pm/V for chromophore loading density at 10, 22.5 and 27.5 wt% respectively. © 2015, Springer Science+Business Media New York. Source


Zhou J.,Chinese Academy of Sciences | Yang H.,Zhejiang University | Li X.,Institute of Basic Medicine | Wang M.,Chinese Academy of Sciences
Journal of Materials Science: Materials in Electronics | Year: 2016

Novel organic second order nonlinear optical chromophore with 4,4′-5-(bis(2-hydroxyethyl)amino)-1,3-phenylene)bis(oxy)dibutan-1-ol as electron donor and azo thiophene as π-electronic bridge was synthesized and characterized by 1H NMR spectra and mass spectra. After the introduction of four hydroxyl groups to the electron donor, the solubility of chromophore Z1 in water was improved greatly (0.5 g). Else, the solubility of chromophore Z1 in common organic solvents was still very good. The thermal decomposition temperature was above 250 °C, which was high enough for its application in both the preparation of optoelectronic devices and Second harmonic generation imaging. Electro-optical films prepared by chromophore Z1 showed us the largest second-order nonlinear optical coefficient was about 85 pm/V, which was large enough for the detection of second harmonic generation signal in water solution. Else, the photochemical stability of chromophore Z1 was also studied; the advantage of chromophore with azo bond was very obvious for improving the photochemical stability of organic second order nonlinear optical chromophores. © 2015, Springer Science+Business Media New York. Source


Zhou J.,Chinese Academy of Sciences | Li X.,Institute of Basic Medicine | Wang M.,Chinese Academy of Sciences
Materials Letters | Year: 2016

Organic nonlinear optical chromophores with different number of N atoms were prepared and characterized. Their nonlinear optical character was studied both by theoretical calculation and second harmonic generation experiment. Chromophore ZJ1 showed us the largest d33 value of 87.5 pm/V. More importantly, the photochemistry stability of the chromophores was also studied in details. Chromophores with N atoms in the conjugated system showed us better photochemistry stability than the traditional chromophores. © 2016 Elsevier B.V. Source


Canbin O.,Chinese Academy of Agricultural Sciences | Li X.,Institute of Basic Medicine | Cao A.,Chinese Academy of Agricultural Sciences
Materials Letters | Year: 2015

In order to explore the application of organic D-π-A molecules in bio-imaging, novel D-π-A molecule (chromophore OY) with multi-hydroxyl groups was designed and synthesized. Compared to the traditional D-π-A molecule, chromophore OY showed us great improvement in water solubility. The solubility of chromophore OY in water could reach 200 ppm. Else, the thermal stability of chromophore OY was also studied. Due to the presence of multi-hydroxyl groups, the thermal stability of chromophore OY was not very good. The initial decomposition temperature was just above 100°C, which was attributed to the dehydration of the hydroxyl groups. Though the SHG effect is not very high, it is large enough for the detection of SHG signal in water solution (0.2-0.3 pm/V). © 2015 Elsevier B.V. All rights reserved. Source


Zhang G.-A.,Jining Medical University | Hou S.,Jining Medical University | Hou S.,Institute of Basic Medicine | Han S.,Jining Medical University | And 3 more authors.
Oncology Letters | Year: 2013

The role of leptin and its receptors (OBRs) in the pathogenesis of various primary human malignancies has been demonstrated. However, their expression and clinicopathological significance in papillary thyroid cancer (PTC) is not fully understood. In this study, we examined the expression of leptin and OBRs in 76 PTC samples using immunohistochemistry, and their associations with clinicopathological parameters were evaluated. The expression of OBRs was observed in the tumor cell membrane and/or cytoplasm, with a positive rate of 73.7% (56/76), while leptin was expressed in the tumor cell cytoplasm in 55 of 76 cases (72.4%). The expression of either protein was associated with greater tumor size (P=0.016 for leptin and P=0.002 for OBRs). In addition, the expression levels of leptin and OBRs were associated with each other. Neither leptin nor OBR expression levels were associated with other parameters, including age, body weight, postmenopausal state, multifocality and lymph node metastasis. These data suggest that the expression of leptin and/or OBRs in PTC is associated with tumor size and may be a potential target in PTC. © 2013 Spandidos Publications Ltd. All rights reserved. Source

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