Potempski S.,European Commission - Joint Research Center Ispra |
Potempski S.,Institute of Atomic Energy of Poland |
Galmarini S.,European Commission - Joint Research Center Ispra |
Riccio A.,Parthenope University of Naples |
Giunta G.,Parthenope University of Naples
Journal of Geophysical Research: Atmospheres | Year: 2010
In this paper, we investigate applicability of Bayesian model averaging (BMA) methodology to atmospheric dispersion multimodel ensemble system within the context of emergency response applications. The BMA method can be used both to evaluate model predictions and to combine model results using BMA weighing factors. We analyze time evolution of BMA weights and include a detailed quantitative comparison of different combinations of model results performed by the means of statistical indicators. The analysis allows us to identify similarities and differences among different combined models. Finally, we question the portability of BMA weights among various cases. From the analysis it follows that BMA can be applied in considered problems; however, the median of the model results also performs well and produces more conservative results. Copyright 2010 by the American Geophysical Union.
Wisniewski R.,Institute of Atomic Energy of Poland |
Wilczynska T.,Institute of Atomic Energy of Poland
Journal of Physics: Conference Series | Year: 2010
A new high-pressure high-shear stress viscometer for pressure up to 400MPa, Couette type (rotational), has been developed. The wide shear rates range and shear stress can be applied for investigations of non-Newtonian liquids. The moment of viscous forces, acting in measuring viscosity cylinders, are measured outside of high-pressure chamber using primary method or using moment (force) sensors. That was realized by use of two counter rotating drive shaft systems with computer controlled stepped motors. As a pressure source a 10:1 intensifier with high-pressure manganin sensor were used. © 2010 IOP Publishing Ltd.
Balcer T.,Institute Of Electronic Materials Technology of Poland |
Wierzchowski W.,Institute Of Electronic Materials Technology of Poland |
Wieteska K.,Institute of Atomic Energy of Poland
Acta Physica Polonica A | Year: 2010
The numerical simulation has been applied for studying of Bragg-case section topographic images of dislocation and rod-like inclusions. The validity of simple approximation of extinction contrast was confirmed in the case of screw dislocations in silicon carbide crystals. A procedure for approximate calculation of the strain field of rod-like inclusion was constructed, consisting of adding the contributions from a very large number of point-like inclusions uniformly distributed inside the assumed volume of the inclusion. The procedure ensured a, reasonable similarity between the simulated topographs and experimental Bragg-case section topographic images of some pipe-formed cavities in silicon carbide crystals. The method is useful for some other materials, e.g. it enabled to compute realistic simulation of plane-wave topographs of the rod-like inclusions in YAG.
Stypulkowska K.,Polish National Medicines Institute |
Blazewicz A.,Polish National Medicines Institute |
Maurin J.,Polish National Medicines Institute |
Maurin J.,Institute of Atomic Energy of Poland |
And 3 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011
The contemporary societies of the developed countries are prone to use traditional far-east medicines as remedies for all diseases. Some of them, such as obesity, might be classified as civilization diseases. Combating the problem, people try not only several miraculous diets but also herbal infusions (teas) and variety of " herbal" preparations. All these believing that such treatment is healthy and harmless as far as it is " natural" Leaving out of the way the question if herbal medicines can be taken safely without doctors' control the query arises if the common preparations are strictly natural and herbal.Here we report examples of quality studies of such medicines using both X-ray powder diffraction (XRPD) and liquid chromatography (LC) with various types of detection: ultraviolet (UV), coulometric electrode array (CEAD) and time-of-flight mass spectrometry (TOF-MS). Especially the XRPD assisted with an optical microscopy seems to be useful as a fast screening method of general sample composition of such preparations. First of all it can discriminate between capsules containing pure herbal materials and those with some chemical. © 2011 Elsevier B.V.
Venhuis B.J.,National Institute for Public Health and the Environment |
Vredenbregt M.V.,National Institute for Public Health and the Environment |
Kaun N.,Royal DSM |
Maurin J.K.,Polish National Medicines Institute |
And 4 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011
Acomplia was ordered over the internet resulting in the delivery of counterfeit Acomplia and imitation products. The tablets were analyzed for the presence of rimonabant. Using LC-DAD-MSn the presence of effective quantities of rimonabant was confirmed in samples A-D. Samples A and D also contained traces of the rimonabant analogue NIDA-41020. Furthermore, NIR spectroscopy on the tablets indicated the presence of an unapproved rimonabant polymorph in samples C and D which was confirmed by Raman spectroscopy and X-ray diffraction (XRD). In sample E a low dose of sibutramine was found as well traces of N-desmethylsibutramine and bis-N-desmethylsibutramine.Rimonabant was withdrawn from the market because of serious adverse events and lack of efficacy. The availability of poor quality products with rimonabant, impurities and unapproved polymorphs is worrying. Suspect weight-loss medicines should be screened for the presence of novel analogues. © 2010.
Fijal-Kirejczyk I.M.,Institute of Atomic Energy of Poland |
Milczarek J.J.,Institute of Atomic Energy of Poland |
Zoladek-Nowak J.,Institute of Atomic Energy of Poland
Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment | Year: 2011
The drying process of wet quartz sand cylinder was studied with neutron radiography as well as with sample temperature and mass measurements. The constant rate and falling rate periods of the process were clearly identified. During the advanced phase of drying, an inner wet region in the sample center was revealed in the neutron radiographs. The emergence of the inner wet region resulted in marked rise in the standard deviation of the brightness of pixels constituting the sample image. The theoretical analysis of the brightness variations was performed in terms of neutron absorption in dry material matrix and water occupying some of the space between sand grains as well as scattering of neutrons on water. It was found that the inner wet region shrinks in radial direction with time while the apparent water content within it remains constant. The different periods of drying have been attributed to capillary transport at the beginning and vapor flow at advanced stages of the process. © 2011 Elsevier B.V. All rights reserved.
Kunikowska J.,Medical University of Warsaw |
Krolicki L.,Medical University of Warsaw |
Hubalewska-Dydejczyk A.,Collegium Medicum Cracow |
Mikolajczak R.,Institute of Atomic Energy of Poland |
And 2 more authors.
European Journal of Nuclear Medicine and Molecular Imaging | Year: 2011
Purpose: Peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues is a treatment option for patients with disseminated neuroendocrine tumours (NET). A combination treatment using the highenergy 90Y beta emitter for larger lesions and the lower energy 177Lu for smaller lesions has been postulated in the literature.The aim of the study was to evaluate combined 90Y/ 177L u-DOTATAT E therapy in comp aris on to 90Y-DOTATAT Ealone. Methods: Fifty patients with disseminated NET were included in the study prospectively and divided into two groups: group A (n=25) was treated with 90Y-DOTATATE, whereas group B (n=25) received the 1: 1 90Y/ 177Lu-DOTATATE. The administered activity was based on 3.7 GBq/m 2 body surface area in three to five cycles, with amino acid infusion for nephroprotection. Results: The median overall survival time in group A was 26.2 months while in group B median survival was not reached. Overall survival was significantly higher in group B (p=0.027). Median event-free survival time in group A was 21.4 months and in group B 29.4 months (p>0.1). At the 12-month follow-up, comparison of group A vs group B showed stable disease (SD) in 13 vs 16 patients, disease regression (RD) in 5 vs 3 patients and disease progression (PD) in 3 vs 4 patients;4 and 2 patients died, respectively. The 24-month follow-up results were SD in nine vs ten patients, RD in one patient vs none and PD in four patients in both groups;three and four patients died, respectively. Side effects were rare and mild. Conclusion: The results indicate that therapy with tandem radioisotopes ( 90Y/ 177Lu-DOTATATE) provides longer overall survival than with a single radioisotope ( 90Y-DOTATATE) and the safety of both methods is comparable. © The Author(s) 2011. This article is published with open access at Springerlink.com.
Czachor A.,Institute of Atomic Energy of Poland
Physics of Particles and Nuclei Letters | Year: 2011
On solving exactly relativistic equations of motion for the model molecule of two particles coupled elastically, it has been shown that in the framework of relativistic mechanics this system, and in general any closed system of interacting particles, is not inertial. In particular, the translational velocity of the mass center of such a system has, as a consequence of the nonlinearity of the equations, oscillatory components reflecting its internal transverse oscillations-it is a pulsed motion. This effect can in principle be seen in the time-of-flight experiments. The force constant of elastic coupling in the system, as seen by the observer at rest, is shown to decline with increase of the total momentum of the system. © 2011 Pleiades Publishing, Ltd.
Komsta L.,Medical University of Lublin |
Maurin J.K.,Polish National Medicines Institute |
Maurin J.K.,Institute of Atomic Energy of Poland
Talanta | Year: 2010
The paper presents an approach to use Partial Least Squares Discriminant Analysis (PLS-DA) on X-ray powder diffractometry (XRPD) dataset to build a model which recognizes a presence (or absence) of particular drug substance (acetaminophen) in unknown mixture (OTC tablet). The dataset consisted of 33 XRPD signals, measured for 12 pure substances and 21 tablets containing them in different quantitative and qualitative ratios, along with unknown excipients. The model was built with an external validation dataset chosen by Kennard-Stone algorithm. The RMSECV value was equal to 0.3461 (87.8% of explained variance) and external predictive error (RMSEP) was equal to 0.3123 (86.2% of explained variance). The result suggests that small but properly prepared training datasets give ability to construct well-working discriminant models on XRPD signals. © 2010 Elsevier B.V. All rights reserved.
Osko J.,Institute of Atomic Energy of Poland |
Golnik N.,Institute of Atomic Energy of Poland |
Pliszczynski T.,Institute of Atomic Energy of Poland
Radiation Protection Dosimetry | Year: 2011
The paper presents four cases of post-accidental contamination with iodine 131I, registered in the Radiation Protection Measurements Laboratory (LPD) of the Institute of Atomic Energy POLATOM. Two cases were registered during routine monitoring of internal exposures carried out at LPD laboratory, one case corresponds to in vivo measurements performed at LPD after Chernobyl accident in 1986, and the last case is associated with an emergency situation after an accident occurred in a Polish hospital. In all cases, thyroid measurements were performed; for hospital employees whole-body and urine measurements were also carried out. © The Author 2010. Published by Oxford University Press. All rights reserved.