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Balcer T.,Institute Of Electronic Materials Technology of Poland | Wierzchowski W.,Institute Of Electronic Materials Technology of Poland | Wieteska K.,Institute of Atomic Energy of Poland
Acta Physica Polonica A | Year: 2010

The numerical simulation has been applied for studying of Bragg-case section topographic images of dislocation and rod-like inclusions. The validity of simple approximation of extinction contrast was confirmed in the case of screw dislocations in silicon carbide crystals. A procedure for approximate calculation of the strain field of rod-like inclusion was constructed, consisting of adding the contributions from a very large number of point-like inclusions uniformly distributed inside the assumed volume of the inclusion. The procedure ensured a, reasonable similarity between the simulated topographs and experimental Bragg-case section topographic images of some pipe-formed cavities in silicon carbide crystals. The method is useful for some other materials, e.g. it enabled to compute realistic simulation of plane-wave topographs of the rod-like inclusions in YAG.

Stypulkowska K.,Polish National Medicines Institute | Blazewicz A.,Polish National Medicines Institute | Maurin J.,Polish National Medicines Institute | Maurin J.,Institute of Atomic Energy of Poland | And 3 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011

The contemporary societies of the developed countries are prone to use traditional far-east medicines as remedies for all diseases. Some of them, such as obesity, might be classified as civilization diseases. Combating the problem, people try not only several miraculous diets but also herbal infusions (teas) and variety of " herbal" preparations. All these believing that such treatment is healthy and harmless as far as it is " natural" Leaving out of the way the question if herbal medicines can be taken safely without doctors' control the query arises if the common preparations are strictly natural and herbal.Here we report examples of quality studies of such medicines using both X-ray powder diffraction (XRPD) and liquid chromatography (LC) with various types of detection: ultraviolet (UV), coulometric electrode array (CEAD) and time-of-flight mass spectrometry (TOF-MS). Especially the XRPD assisted with an optical microscopy seems to be useful as a fast screening method of general sample composition of such preparations. First of all it can discriminate between capsules containing pure herbal materials and those with some chemical. © 2011 Elsevier B.V.

Venhuis B.J.,National Institute for Public Health and the Environment | Vredenbregt M.V.,National Institute for Public Health and the Environment | Kaun N.,Royal DSM | Maurin J.K.,Polish National Medicines Institute | And 4 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011

Acomplia was ordered over the internet resulting in the delivery of counterfeit Acomplia and imitation products. The tablets were analyzed for the presence of rimonabant. Using LC-DAD-MSn the presence of effective quantities of rimonabant was confirmed in samples A-D. Samples A and D also contained traces of the rimonabant analogue NIDA-41020. Furthermore, NIR spectroscopy on the tablets indicated the presence of an unapproved rimonabant polymorph in samples C and D which was confirmed by Raman spectroscopy and X-ray diffraction (XRD). In sample E a low dose of sibutramine was found as well traces of N-desmethylsibutramine and bis-N-desmethylsibutramine.Rimonabant was withdrawn from the market because of serious adverse events and lack of efficacy. The availability of poor quality products with rimonabant, impurities and unapproved polymorphs is worrying. Suspect weight-loss medicines should be screened for the presence of novel analogues. © 2010.

Czachor A.,Institute of Atomic Energy of Poland
Physics of Particles and Nuclei Letters | Year: 2011

On solving exactly relativistic equations of motion for the model molecule of two particles coupled elastically, it has been shown that in the framework of relativistic mechanics this system, and in general any closed system of interacting particles, is not inertial. In particular, the translational velocity of the mass center of such a system has, as a consequence of the nonlinearity of the equations, oscillatory components reflecting its internal transverse oscillations-it is a pulsed motion. This effect can in principle be seen in the time-of-flight experiments. The force constant of elastic coupling in the system, as seen by the observer at rest, is shown to decline with increase of the total momentum of the system. © 2011 Pleiades Publishing, Ltd.

Potempski S.,European Commission - Joint Research Center Ispra | Potempski S.,Institute of Atomic Energy of Poland | Galmarini S.,European Commission - Joint Research Center Ispra | Riccio A.,Parthenope University of Naples | Giunta G.,Parthenope University of Naples
Journal of Geophysical Research: Atmospheres | Year: 2010

In this paper, we investigate applicability of Bayesian model averaging (BMA) methodology to atmospheric dispersion multimodel ensemble system within the context of emergency response applications. The BMA method can be used both to evaluate model predictions and to combine model results using BMA weighing factors. We analyze time evolution of BMA weights and include a detailed quantitative comparison of different combinations of model results performed by the means of statistical indicators. The analysis allows us to identify similarities and differences among different combined models. Finally, we question the portability of BMA weights among various cases. From the analysis it follows that BMA can be applied in considered problems; however, the median of the model results also performs well and produces more conservative results. Copyright 2010 by the American Geophysical Union.

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