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Bidabad M.S.,University of Isfahan | Saniei S.Z.,Institute of Advanced Technology ITMA
2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013 | Year: 2013

Conventional biomaterials have been used in a wide range of application in our life for centuries. Medical devices and artificial parts of human body are the most important of them. Among of all biomaterial family replaceable biomaterials with hard tissue have a longer history. They must place for long time in human body instead of damaged tissue without their properties will dwindle. In fact they should be used permanently and replacing them needs to re-surgery and different side effects for patients. Therefore, rejection probability in their application must be minimized. Bulk metallic glass alloys have been propounded seriously for 50 years, however they can not be used in large scale and with high thickness in industrial applications because of technical problems and high production coast reasons, but using MG alloys as coat could be economical and practicable. In this research a new amorphous biomaterial was introduced in coating form. This new biocoating with chemical formula Ti64Cu12Zr11Co5(Mo,Nb) was deposited by a pulse laser deposition technique that applied target is non-amorphous. By controlling process conditions such as laser power, amorphicity was maximized and coating was fully metallic glass. Achieved hardness from this coating is (570-600 HV) that was measured by micro hardness machine from achieved coating surface. This coating had no allergic effect or elements in its composition. The cytoxicity evaluations such as acute toxicity and MTT tests provide evidence that this coat doesn't have any toxic effect and could be candidate medical and dental applications. © 2013 IEEE. Source


Ismail S.,Institute of Advanced Technology ITMA | Mansor S.,Institute of Advanced Technology ITMA | Rodsi A.,Institute of Advanced Technology ITMA | Bujang B.K.,University Putra Malaysia
Environmental Earth Sciences | Year: 2011

This study presents a modified geotechnical model of subsurface cavities and fractures that are associated with foundation and pilling problems. The topographical model was used to automatically extract minimum surface curvature, slope, and pits. The image processing shows that more than fourteen regional faults, trending NE, SW, and WNW affect the Kuala Lumpur limestone bedrock and the surface topography from South to North. These fractures often show higher probability of piling and constructions problems. The faults are tensional, low lying, and wrench of length 10-20 km. Opencast exmining pond floors (bathymetry) are good indicators of subsurface fractures and cavities that affect the limestone bedrock. The LANDSAT image (band one) shows that the fractures of opencast ex-mining pond floors have the same trend as the regional faults. These techniques can help geotechnical engineers to predict subsurface fractures and cavities, especially in areas adjacent to ex-mining ponds. In brief, most of the subsurface cavities and ex-mining ponds, for example the Phong Fatt pond, are located on and along fault zones. © 2010 Springer-Verlag. Source


Barahuie F.,Institute of Advanced Technology ITMA | Hussein M.Z.,Institute of Advanced Technology ITMA | Hussein-Al-Ali S.H.,Institute of Bioscience | Arulselvan P.,Bioscience Vaccines | And 3 more authors.
International Journal of Nanomedicine | Year: 2013

In the study reported here, magnesium/aluminum (Mg/Al)-layered double hydroxide (LDH) was intercalated with an anticancer drug, protocatechuic acid, using ionexchange and direct coprecipitation methods, with the resultant products labeled according to the method used to produce them: PANE (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the ion-exchange method) and PAND (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the direct method), respectively. Powder X-ray diffraction and Fourier transform infrared spectroscopy confirmed the intercalation of protocatechuic acid into the inter-galleries of Mg/Al-LDH. The protocatechuic acid between the interlayers of PANE and PAND was found to be a monolayer, with an angle from the z-axis of 8° for PANE and 15° for PAND. Thermogravimetric and differential thermogravimetric analysis results revealed that the thermal stability of protocatechuic acid was markedly enhanced upon intercalation. The loading of protocatechuic acid in PANE and PAND was estimated to be about 24.5% and 27.5% (w/w), respectively. The in vitro release study of protocatechuic acid from PANE and PAND in phosphate-buffered saline at pH 7.4, 5.3, and 4.8 revealed that the nanocomposites had a sustained release property. After 72 hours incubation of PANE and PAND with MCF-7 human breast cancer and HeLa human cervical cancer cell lines, it was found that the nanocomposites had suppressed the growth of these cancer cells, with a half maximal inhibitory concentration of 35.6 μg/mL for PANE and 36.0 μg/mL for PAND for MCF-7 cells, and 19.8 μg/mL for PANE and 30.3 μg/mL for PAND for HeLa cells. No half maximal inhibitory concentration for either nanocomposite was found for 3T3 cells. 2013 Barahuie et al, publisher and licensee Dove Medical Press Ltd. Source


Shuib S.,Universiti Sains Malaysia | Sahari B.B.,Institute of Advanced Technology ITMA | Voon W.S.,Institute of Advanced Technology ITMA | Arumugam M.,Institute of Advanced Technology ITMA
Trends in Biomaterials and Artificial Organs | Year: 2012

Finite element (FE) simulation has become increasingly important to analyze the behavior of the femoral bone when it is subjected to external loads. The aim of the present study was to validate FE simulation with experimental work using surface strain at the outer surface of the femur, and to subsequently, evaluate von Mises strain for its inner surface. A standardized femur from the bone repository in the Biomechanics European Laboratory (BEL) in Italy was used for the analysis as a base for finite element modeling. The material model used for the analysis was assumed to be isotropic and linearly elastic, and the external loads applied comprised of a head load and an abductor load. The values of stress and strain in the anterior, posterior, medial, and lateral positions of the femur have been presented in this report. The results from the present study show that strain distribution is not uniform across the section of the femur, suggesting the occurrence of circumferential bending. Thus, better understanding of von Mises strain on the inner surface of the femur is important for total hip replacements (THRs). Source


Hajalilou A.,Institute of Advanced Technology ITMA | Hashim M.,Institute of Advanced Technology ITMA | Ebrahimi-Kahrizsangi R.,Islamic Azad University at Najafabad | Mohamed Kamari H.,University Putra Malaysia | Sarami N.,Isfahan University of Technology
Ceramics International | Year: 2014

NiFe2O4 nanoparticles were synthesized by a mechanochemical reaction of NiO and Fe2O3 powders in a high energy planetary ball milling machine. The XRD characterization results suggested that in the case of nano ferrite, milling up to 18 h formed NiFe 2O4 particles of 10 nm with some residual Fe 2O3 particles through a solid state reaction. By extending milling time to 30 h, the amorphous phase of NiFe2O4 was produced due to the high energy released during mechanical activation. The mechanism was identified as one of diffusion and counter-diffusion of Ni +2 and Fe+3 ions of the starting materials into each other. FT-IR analysis showed two absorption bands in the nickel ferrite structure related to octahedral and tetrahedral sites, respectively, in the range of 400-600 cm-1. The vibrating sample magnetometric (VSM) studies showed that the nano-sized particles of nickel ferrite exhibited a ferromagnetic behavior and its coercivity was approximately negligible. © 2013 Elsevier Ltd and Techna Group S.r.l. Source

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