Institute of Advanced Technology ITMA

Malaysia

Institute of Advanced Technology ITMA

Malaysia
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Ramlan N.F.,University Putra Malaysia | Sata N.S.A.M.,University Putra Malaysia | Hassan S.N.,University Putra Malaysia | Bakar N.A.,University Putra Malaysia | And 5 more authors.
Behavioural Brain Research | Year: 2017

Exposure to ethanol during critical period of development can cause severe impairments in the central nervous system (CNS). This study was conducted to assess the neurotoxic effects of chronic embryonic exposure to ethanol in the zebrafish, taking into consideration the time dependent effect. Two types of exposure regimen were applied in this study. Withdrawal exposure group received daily exposure starting from gastrulation until hatching, while continuous exposure group received daily exposure from gastrulation until behavioural assessment at 6 dpf (days post fertilization). Chronic embryonic exposure to ethanol decreased spontaneous tail coiling at 24 hpf (hour post fertilization), heart rate at 48 hpf and increased mortality rate at 72 hpf. The number of apoptotic cells in the embryos treated with ethanol was significantly increased as compared to the control. We also measured the morphological abnormalities and the most prominent effects can be observed in the treated embryos exposed to 1.50% and 2.00%. The treated embryos showed shorter body length, larger egg yolk, smaller eye diameter and heart edema as compared to the control. Larvae received 0.75% continuous ethanol exposure exhibited decreased swimming activity and increased anxiety related behavior, while withdrawal ethanol exposure showed increased swimming activity and decreased anxiety related behavior as compared to the respective control. Biochemical analysis exhibited that ethanol exposure for both exposure regimens altered proteins, lipids, carbohydrates and nucleic acids of the zebrafish larvae. Our results indicated that time dependent effect of ethanol exposure during development could target the biochemical processes thus leading to induction of apoptosis and neurobehavioral deficits in the zebrafish larvae. Thus it raised our concern about the safe limit of alcohol consumption for pregnant mother especially during critical periods of vulnerability for developing nervous system. © 2017 Elsevier B.V.


Abu Bakar N.,University Putra Malaysia | Mohd Sata N.S.A.,University Putra Malaysia | Ramlan N.F.,University Putra Malaysia | Wan Ibrahim W.N.,University Putra Malaysia | And 5 more authors.
Neurotoxicology and Teratology | Year: 2017

Chronic exposure to mercury (Hg) can lead to cumulative impairments in motor and cognitive functions including alteration in anxiety responses. Although several risk factors have been identified in recent year, little is known about the environmental factors that either due exposure toward low level of inorganic mercury that may led to the developmental disorders. The present study investigated the effects of embryonic exposure of mercury chloride on motor function and anxiety-like behavior. The embryo exposed to 6 different concentrations of HgCl2 (7.5, 15, 30, 100, 125, 250 nM) at 5 hpf until hatching (72 hpf) in a semi-static condition. The mortality rate increased in a dose dependent manner where the chronic embryonic exposure to 100 nM decreased the number of tail coiling, heartbeat, and swimming activity. Aversive stimulus was used to examine the effects of 100 nM interferes with the development of anxiety-related behavior. No elevation in both thigmotaxis and avoidance response of 6 dpf larvae exposed with 100 nM were found. Biochemical analysis showed HgCl2 exposure affects proteins, lipids, carbohydrates and nucleic acids of the zebrafish larvae. These results showed that implication of HgCl2 on locomotor and biochemical defects affects motor performance and anxiety-like responses. Yet, the potential underlying mechanisms these responses need to be further investigated which is crucial to prevent potential hazards on the developing organism due to neurotoxicant exposure. © 2016 Elsevier Inc.


Bashi A.M.,University of Basrah | Bashi A.M.,Institute of Advanced Technology ITMA | Hussein M.Z.,Institute of Advanced Technology ITMA | Hussein M.Z.,University Putra Malaysia | And 4 more authors.
Arabian Journal of Chemistry | Year: 2012

A new nanohybrid compound was formed by the concurrent insertion of 2,4-dichlorophenoxy acetate (DPA) used as herbicides and 4-chlorophenoxy acetate (CPA) as plant growth regulator, the two guest anions into the interlamellar space of the host Zn/Al layered double hydroxide (LDH) using co-precipitation or spontaneous self-assembly method. Two different basal spacings of 2.54 and 1.97 nm were detected by PXRD of the nanohybrid accounting for the presence of two distinct intercalated phases. Direct insertion mass spectroscopy (DIMS) analyses confirm that both anions are intercalated to give a biphasic well ordered nanohybrid material. The study of the release properties shows that both ions were released, but with different rates. This opens up the possibility of using such a biphasic nanohybrid for controlled release of more than one active anionic agent at different controlled rates. © 2012.


Ismail S.,Institute of Advanced Technology ITMA | Mansor S.,Institute of Advanced Technology ITMA | Rodsi A.,Institute of Advanced Technology ITMA | Bujang B.K.,University Putra Malaysia
Environmental Earth Sciences | Year: 2011

This study presents a modified geotechnical model of subsurface cavities and fractures that are associated with foundation and pilling problems. The topographical model was used to automatically extract minimum surface curvature, slope, and pits. The image processing shows that more than fourteen regional faults, trending NE, SW, and WNW affect the Kuala Lumpur limestone bedrock and the surface topography from South to North. These fractures often show higher probability of piling and constructions problems. The faults are tensional, low lying, and wrench of length 10-20 km. Opencast exmining pond floors (bathymetry) are good indicators of subsurface fractures and cavities that affect the limestone bedrock. The LANDSAT image (band one) shows that the fractures of opencast ex-mining pond floors have the same trend as the regional faults. These techniques can help geotechnical engineers to predict subsurface fractures and cavities, especially in areas adjacent to ex-mining ponds. In brief, most of the subsurface cavities and ex-mining ponds, for example the Phong Fatt pond, are located on and along fault zones. © 2010 Springer-Verlag.


Bidabad M.S.,University of Isfahan | Saniei S.Z.,Institute of Advanced Technology ITMA
2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013 | Year: 2013

Conventional biomaterials have been used in a wide range of application in our life for centuries. Medical devices and artificial parts of human body are the most important of them. Among of all biomaterial family replaceable biomaterials with hard tissue have a longer history. They must place for long time in human body instead of damaged tissue without their properties will dwindle. In fact they should be used permanently and replacing them needs to re-surgery and different side effects for patients. Therefore, rejection probability in their application must be minimized. Bulk metallic glass alloys have been propounded seriously for 50 years, however they can not be used in large scale and with high thickness in industrial applications because of technical problems and high production coast reasons, but using MG alloys as coat could be economical and practicable. In this research a new amorphous biomaterial was introduced in coating form. This new biocoating with chemical formula Ti64Cu12Zr11Co5(Mo,Nb) was deposited by a pulse laser deposition technique that applied target is non-amorphous. By controlling process conditions such as laser power, amorphicity was maximized and coating was fully metallic glass. Achieved hardness from this coating is (570-600 HV) that was measured by micro hardness machine from achieved coating surface. This coating had no allergic effect or elements in its composition. The cytoxicity evaluations such as acute toxicity and MTT tests provide evidence that this coat doesn't have any toxic effect and could be candidate medical and dental applications. © 2013 IEEE.


Hajalilou A.,Institute of Advanced Technology ITMA | Hashim M.,Institute of Advanced Technology ITMA | Ebrahimi-Kahrizsangi R.,Islamic Azad University at Najafabad | Mohamed Kamari H.,University Putra Malaysia | Sarami N.,Isfahan University of Technology
Ceramics International | Year: 2014

NiFe2O4 nanoparticles were synthesized by a mechanochemical reaction of NiO and Fe2O3 powders in a high energy planetary ball milling machine. The XRD characterization results suggested that in the case of nano ferrite, milling up to 18 h formed NiFe 2O4 particles of 10 nm with some residual Fe 2O3 particles through a solid state reaction. By extending milling time to 30 h, the amorphous phase of NiFe2O4 was produced due to the high energy released during mechanical activation. The mechanism was identified as one of diffusion and counter-diffusion of Ni +2 and Fe+3 ions of the starting materials into each other. FT-IR analysis showed two absorption bands in the nickel ferrite structure related to octahedral and tetrahedral sites, respectively, in the range of 400-600 cm-1. The vibrating sample magnetometric (VSM) studies showed that the nano-sized particles of nickel ferrite exhibited a ferromagnetic behavior and its coercivity was approximately negligible. © 2013 Elsevier Ltd and Techna Group S.r.l.


Shuib S.,Universiti Sains Malaysia | Sahari B.B.,Institute of Advanced Technology ITMA | Voon W.S.,Institute of Advanced Technology ITMA | Arumugam M.,Institute of Advanced Technology ITMA
Trends in Biomaterials and Artificial Organs | Year: 2012

Finite element (FE) simulation has become increasingly important to analyze the behavior of the femoral bone when it is subjected to external loads. The aim of the present study was to validate FE simulation with experimental work using surface strain at the outer surface of the femur, and to subsequently, evaluate von Mises strain for its inner surface. A standardized femur from the bone repository in the Biomechanics European Laboratory (BEL) in Italy was used for the analysis as a base for finite element modeling. The material model used for the analysis was assumed to be isotropic and linearly elastic, and the external loads applied comprised of a head load and an abductor load. The values of stress and strain in the anterior, posterior, medial, and lateral positions of the femur have been presented in this report. The results from the present study show that strain distribution is not uniform across the section of the femur, suggesting the occurrence of circumferential bending. Thus, better understanding of von Mises strain on the inner surface of the femur is important for total hip replacements (THRs).


Barahuie F.,Institute of Advanced Technology ITMA | Hussein M.Z.,Institute of Advanced Technology ITMA | Hussein-Al-Ali S.H.,Institute of Bioscience | Arulselvan P.,Bioscience Vaccines | And 3 more authors.
International Journal of Nanomedicine | Year: 2013

In the study reported here, magnesium/aluminum (Mg/Al)-layered double hydroxide (LDH) was intercalated with an anticancer drug, protocatechuic acid, using ionexchange and direct coprecipitation methods, with the resultant products labeled according to the method used to produce them: PANE (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the ion-exchange method) and PAND (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the direct method), respectively. Powder X-ray diffraction and Fourier transform infrared spectroscopy confirmed the intercalation of protocatechuic acid into the inter-galleries of Mg/Al-LDH. The protocatechuic acid between the interlayers of PANE and PAND was found to be a monolayer, with an angle from the z-axis of 8° for PANE and 15° for PAND. Thermogravimetric and differential thermogravimetric analysis results revealed that the thermal stability of protocatechuic acid was markedly enhanced upon intercalation. The loading of protocatechuic acid in PANE and PAND was estimated to be about 24.5% and 27.5% (w/w), respectively. The in vitro release study of protocatechuic acid from PANE and PAND in phosphate-buffered saline at pH 7.4, 5.3, and 4.8 revealed that the nanocomposites had a sustained release property. After 72 hours incubation of PANE and PAND with MCF-7 human breast cancer and HeLa human cervical cancer cell lines, it was found that the nanocomposites had suppressed the growth of these cancer cells, with a half maximal inhibitory concentration of 35.6 μg/mL for PANE and 36.0 μg/mL for PAND for MCF-7 cells, and 19.8 μg/mL for PANE and 30.3 μg/mL for PAND for HeLa cells. No half maximal inhibitory concentration for either nanocomposite was found for 3T3 cells. 2013 Barahuie et al, publisher and licensee Dove Medical Press Ltd.

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