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Hussein-Al-Ali S.H.,Laboratory of Molecular Biomedicine | El Zowalaty M.E.,Bioscience Vaccines | El Zowalaty M.E.,Jazan University | Hussein M.Z.,Institute of Advanced Technology | And 5 more authors.
International Journal of Nanomedicine | Year: 2014

Iron oxide magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of iron salts in sodium hydroxide followed by coating separately with chitosan (CS) and polyethylene glycol (PEG) to form CS-MNPs and PEG-MNPs nanoparticles, respectively. They were then loaded with kojic acid (KA), a pharmacologically bioactive natural compound, to form KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The MNPs and their nanocomposites were characterized using powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, and scanning electron microscopy. The powder X-ray diffraction data suggest that all formulations consisted of highly crystalline, pure magnetite Fe3O4. The Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the presence of both polymers and KA in the nanocomposites. Magnetization curves showed that both nanocomposites (KA-CS-MNPs and KA-PEG-MNPs) were superparamagnetic with saturation magnetizations of 8.1 emu/g and 26.4 emu/g, respectively. The KA drug loading was estimated using ultraviolet-visible spectroscopy, which gave a loading of 12.2% and 8.3% for the KA-CS-MNPs and KA-PEG-MNPs nanocomposites, respectively. The release profile of the KA from the nanocomposites followed a pseudo second-order kinetic model. The agar diffusion test was performed to evaluate the antimicrobial activity for both KA-CS-MNPs and KA-PEG-MNPs nanocomposites against a number of microorganisms using two Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus subtilis) and one Gram-negative (Salmonella enterica) species, and showed some antibacterial activity, which could be enhanced in future studies by optimizing drug loading. This study provided evidence for the promise for the further investigation of the possible beneficial biological activities of KA and both KA-CS-MNPs and KA-PEG-MNPs nanocomposites in nanopharmaceutical applications. © 2014 Hussein-Al-Ali et al. Source


Japar S.,Institute of Advanced Technology | Salit M.S.,Institute of Advanced Technology | Salit M.S.,University Putra Malaysia
Journal of Polymer Materials | Year: 2012

This paper focusses on the review of development and properties of biodegradable and sustainable polymers which become an attracting area in materials science research. The basic properties and recent development in sustainable polymers such as poly lactide (PLA), thermoplastic starch (TPS), cellulose andpolyhydroxyalkanoates (PHAs) were reviewed in this paper. This paper also provides a general overview of some important topics in biopolymers such as chemical, processing, mechanical and physical properties. © MD Publications Pvt. Ltd. Source


Kura A.U.,Institute of Bioscience | Ali S.H.H.A.,Institute of Bioscience | Hussein M.Z.,Institute of Advanced Technology | Fakurazi S.,Institute of Bioscience | And 2 more authors.
International Journal of Nanomedicine | Year: 2013

A new layered organic-inorganic nanocomposite material with an anti-parkinsonian active compound, L-3-(3,4-dihydroxyphenyl) alanine (levodopa), intercalated into the inorganic interlayers of a Zn/Al-layered double hydroxide (LDH) was synthesized using a direct copre- cipitation method. The resulting nanocomposite was composed of the organic moiety, levodopa, sandwiched between Zn/Al-LDH inorganic interlayers. The basal spacing of the resulting nano-composite was 10.9 Å. The estimated loading of levodopa in the nanocomposite was approximately 16% (w/w). A Fourier transform infrared study showed that the absorption bands of the nanocomposite were characteristic of both levodopa and Zn/Al-LDH, which further confirmed intercalation, and that the intercalated organic moiety in the nanocomposite was more thermally stable than free levodopa. The resulting nanocomposite showed sustained-release properties, so can be used in a controlled-release formulation. Cytotoxicity analysis using an MTT assay also showed increased cell viability of 3T3 cells exposed to the newly synthesized nanocomposite compared with those exposed to pure levodopa after 72 hours of exposure. © 2013 Kura et al, publisher and licensee Dove Medical Press Ltd. Source


Ahsan A.,University Putra Malaysia | Ahsan A.,Institute of Advanced Technology | Imteaz M.,Swinburne University of Technology | Dev R.,Motilal Nehru National Institute of Technology | Arafat H.A.,Masdar Institute of Science and Technology
Desalination | Year: 2013

In this paper, a detailed comparison of a few numerical models (with and without considering humid air properties) for the estimation of water production from a solar water distillation device is investigated. An extensive laboratory production experiments were executed under fifteen sets of external conditions to find the properties of evaporation and condensation coefficients to incorporate with the present evaporation and condensation models (two unique and independent theoretical models), respectively. The calculation accuracy of the evaporation flux computed by two evaporation models (present and previous), Dunkle's and Ueda's model, and of the hourly condensation flux estimated by two condensation models (present and previous) was examined using the field experimental results. It was found that the previous evaporation and condensation models using empirical relationships extremely overestimated and underestimated the observed production flux, respectively. The evaporation flux calculated by the conventional models of Dunkle and Ueda notably underestimated and overestimated the observed values, respectively. Finally, it is revealed that the present models have the smallest deviation between the calculated and the observed values among these six models and can predict the daily production flux. © 2012 Elsevier B.V. Source


Pradhan B.,Institute of Advanced Technology
Proceedings - 2012 IEEE 8th International Colloquium on Signal Processing and Its Applications, CSPA 2012 | Year: 2012

Landslides are one of the most important natural hazards which have been a major focus of investigation for international community. The consequences from its occurrences are highly contributed to enormous damages and economical losses in Malaysia. This has been recognized by many professional authorities and has led to a number of landslide hazard and risk mapping both in qualitative and quantitative ways. In this research, LiDAR data was used to generate landslide geomorphological surface. The landslide conditioning factors considered for the study area were slope gradient, curvature, topographic wetness index and soil type. The correlation of each parameter with landslide occurrences was then measured by using probabilistic based frequency ratio method and landslide susceptibility map was produced. The landslide susceptibility map can be very useful for general landuse planning © 2012 IEEE. Source

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