Institute National Of Sante

Illkirch-Graffenstaden, France

Institute National Of Sante

Illkirch-Graffenstaden, France
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Tourigny A.,Institute National Of Sante | Durand P.,Faculte | Bonin L.,Institute National Of Sante | Sevigny A.,Faculte
Canadian Journal on Aging | Year: 2015

The rising number of older people living with disabilities and chronic diseases has increased home care needs. Studies and reviews exploring preventive approaches have proliferated, creating a need for a synthesis of evidence. We conducted a systematic review of systematic reviews to evaluate the effectiveness of preventive home visiting approaches for older people. Of the 5,973 citations identified in over 30 scientific and grey literature databases, 10 papers met all inclusion criteria. Systematic reviews were considered if they included controlled trials comparing interventions with and without professional home care. We found that interventions often included comprehensive geriatric assessments and follow-up visits. Results indicate that multidimensional preventive home visiting programs might have the potential to reduce mortality, in particular for younger subjects, and show a potential to improve functional autonomy, but these findings should be interpreted with caution due to the diversity of the interventions analysed. © 2015 Canadian Association on Gerontology.

Bissouma A.-C.,University of Paris 13 | Anoumatacky M.,Programme National de Sante Mentale | Bonle M.T.E.,Institute National Of Sante | Delafosse R.,Programme National de Sante Mentale | Fourment M.-C.,University of Paris 13
Psychiatrie de l'Enfant | Year: 2013

Born in its modern acceptance in the twentieth century, ivoirian's psychiatry and its corollary psychiatrist child are still searching for their identity. But it cannot be built by taking into account the great movements of history and philosophy which has subtended. Hazera Max has been a major player in the ivorian's psychiatry and his vision has greatly influenced the great moments of its construction. It is the duty of remembering that the authors attempt to honor by writing the history of an evolving discipline in a context of profound changes in society and how it tries to meet the challenges.

Berger I.,EMBL Grenoble | Blanco A.G.,Institute Of Biologia Molecular Of Barcelona Csic | Blanco A.G.,Barcelona Institute for Research in Biomedicine | Boelens R.,University Utrecht | And 22 more authors.
Journal of Structural Biology | Year: 2011

Control of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression. © 2011 Elsevier Inc.

Gagnon R.,Laval University | Primeau M.N.,McGill University | Roches A.D.,University of Montréal | Lemire C.,Université de Sherbrooke | And 5 more authors.
Journal of Allergy and Clinical Immunology | Year: 2010

Background: Because influenza vaccine contains some residual egg protein, there is a theoretic risk of anaphylaxis when vaccinating patients with egg allergy. The objective of this study was to estimate the risk of anaphylaxis in children with egg allergy administered an adjuvanted monovalent 2009 pandemic influenza A/H1N1 influenza vaccine (Arepanrix; GlaxoSmithKline, Mississauga, Ontario, Canada). Methods: Patients with confirmed egg allergy with a history of respiratory or cardiovascular reactions after egg ingestion were vaccinated in 2 divided doses (10% and 90%) administered at a 30-minute interval, whereas children with other types of egg- induced allergic reactions were vaccinated with a single dose. All patients remained under observation for 60 minutes after vaccination. A 24-hour follow-up telephone call was made to detect any delayed reaction. The main outcome was the occurrence of an anaphylactic reaction according to criteria specified by the Brighton Collaboration. Results: Among the 830 patients with confirmed egg allergy, only 9% required the vaccine to be administered in divided doses. No patient had an anaphylactic reaction. Nine patients had minor allergic symptoms treated with an antihistamine (1 in the 60 minutes after vaccination and 8 in the following 23 hours), and 3 others received salbutamol (1 in the first 60 minutes after vaccination). Further vaccination of more than 3600 other children with reported egg allergy caused no anaphylaxis based on the criteria of the Brighton Collaboration, although 2 patients received epinephrine for symptoms compatible with allergy. Conclusion: Although anaphylaxis after influenza immunization is a theoretic risk, vaccination of patients with egg allergy with an adjuvanted monovalent pH1N1 influenza vaccine resulted in no cases of anaphylaxis and on that basis appears safe. (J Allergy Clin Immunol 2010;126:317-23.) © 2010 American Academy of Allergy, Asthma & Immunology.

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