Institute National Of Recherche Et Danalyse Physico Chimique Sidi Thabet

Tunis, Tunisia

Institute National Of Recherche Et Danalyse Physico Chimique Sidi Thabet

Tunis, Tunisia

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Kouass S.,Institute National Of Recherche Et Danalyse Physico Chimique Sidi Thabet | Selmi A.,Gafsa University | Selmi A.,University of Carthage | Chebbi H.,University of Tunis | And 3 more authors.
Journal of Structural Chemistry | Year: 2016

A new potassium cadmium hydrogen diphosphate dihydrate, KCdHP2O7∙2H2O (1), has been synthesized by slow evaporation at room temperature and characterized by FT-IR, Raman, TG-DTA, and single crystal X-ray diffraction. Compound (1) crystallizes in the orthorhombic Pcmn space group with the unit cell parameters a = 6.5814(8) Å, b = 7.9428(9) Å, c = 15.961(6) Å, V = 834.4(3) Å3 and Z = 4. Its structure consists of polyhedral layers parallel to the ab plane where each CdO6 octahedron (m position) shares four edges with three different diphosphate groups. In the Cd octahedron, two oxygen atoms residing in (m) special positions belong to coordinated water molecules. These layers are joint by K+ cations (4c Wyckoff position) and hydrogen bonds, leading thus to a two-dimensional framework. The structural model is supported by the bond-valence-sum validation tool as calculated valences are close to the formal oxidation numbers. © 2016, Pleiades Publishing, Ltd.


Jabri M.-A.,University of Carthage | Jabri M.-A.,Jendouba University | Jabri M.-A.,French Institute of Health and Medical Research | Rtibi K.,Jendouba University | And 8 more authors.
RSC Advances | Year: 2015

We aimed in the present study to investigate the protective effect of a myrtle (Myrtus communis L.) berry seed aqueous extract (MBSAE) on acetic acid (AA)-induced colitis in rats as well as the mechanism implicated in this coli-protection. The use of the LC/MS technique allowed us to identify 18 phenolic compounds in the MBSAE. Secondly, we found that the MBSAE inhibited the luminol-amplified chemiluminescence of resting neutrophils and N-formyl-methionylleucyl-phenylalanine (fMLF) or phorbolmyristate acetate (PMA) stimulated neutrophils in a dose-dependent manner. The MBSAE had no effect on superoxide anions, but it inhibited H2O2 production in the cell free system stimulated with horseradish peroxidase (HRPO) and MPO release from the neutrophils. In vivo, the pre-treatment of rats with sulfasalazine (100 mg kg-1) and the MBSAE (25, 50, and 100 mg kg-1) significantly reduced AA-induced colonic mucosa lesions as well as histopathological changes. The MBSAE counteracted AA-induced lipid peroxidation and the depletion of the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). We also found that the myrtle extract inhibited the increase of the plasma scavenging activity (PSA) and preserved the content of non-enzymatic antioxidants such as sulfhydryl groups (-SH) and reduced glutathione (GSH). More importantly, acetic acid administration increased colonic hydrogen peroxide (H2O2), free iron and calcium levels, while the MBSAE pre-treatment reversed all intracellular mediator perturbations. In conclusion, our data suggests that the MBSAE exerted a potential protective effect against AA-induced injury and oxidative stress in the rat colon. This coli-protection might be related in part to its antioxidant and ROS scavenging activities or by negatively regulating Fenton reaction components such as H2O2 and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation. © 2015 The Royal Society of Chemistry.


Sebai H.,University of Carthage | Sebai H.,Institute Superieur Of Biotechnologie Of Beja | Jabri M.-A.,University of Carthage | Jabri M.-A.,Institute Superieur Of Biotechnologie Of Beja | And 8 more authors.
RSC Advances | Year: 2014

The present study aims at evaluating the antiulcer and antioxidant effect of Artemisia campestris aqueous extract (ACAE) as well as the mechanism of action involved in such gastroprotection. The use of LC/MS allowed the identification of 11 phenolic compounds and the colorimetric analysis demonstrated that the ACAE exhibited an important in vitro antioxidant activity. We first showed that in vivo ACAE protected against macroscopic and histological changes induced by aspirin in stomach mucosa. Aspirin administration was accompanied by an oxidative stress status assessed by an increase in malondialdehyde (MDA) level, a decrease in the content of sulfhydryl -(SH) groups and a depletion of antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Pre-treatment with ACAE protected against aspirin-induced gastric oxidative stress. More importantly, aspirin administration increased plasma and tissue hydrogen peroxide (H2O2), free iron and calcium levels, while the ACAE pre-treatment reversed all the effects of aspirin-induced intracellular mediators. In conclusion, we suggest that Artemisia campestris aqueous extract has potent antiulcer and antioxidant properties. This gastroprotection offered by ACAE might be related partly to the safety of sulfhydryl group as well as its opposite effect on some intracellular mediators such as hydrogen peroxide, free iron and calcium. This journal is © the Partner Organisations 2014.


Dhaouadi H.,Institute National Of Recherche Et Danalyse Physicochimique | Kouass S.,Institute National Of Recherche Et Danalyse Physicochimique | Jaouad N.,Institute National Of Recherche Et Danalyse Physico Chimique Sidi Thabet | Ghodbane O.,Institute National Of Recherche Et Danalyse Physicochimique | Touati F.,Institute National Of Recherche Et Danalyse Physicochimique
Materials Research Bulletin | Year: 2014

The nanostructured pyrophosphate Ni0.25Co0.75MnP 2O7 was prepared. The synthesis technique was based on the hydrothermal method at 150 C using poly-ethylene-glycol (PEG-10000) as surfactant with further calcination at 500 C. A structural analysis of Ni 0.25Co0.75MnP2O7 compound was carried out by applying X-ray diffraction (XRD) and using the Rietveld method. Morphological characterizations were performed using a scanning electron microscope (SEM) and transmission electron microscopy (TEM). A comparative study of the electrical conductivity of Mn2P2O7 and Ni0.25Co0.75MnP2O7 nanomaterials was carried out by impedance spectroscopy in the temperature range 500-680 C. The activation energies for MnP2O7 and Ni 0.25Co0.75MnP2O7 were 2.00 and 0.88 eV, respectively. Ni0.25Co0.75MnP2O7 nanomaterial presents a good electric conductivity compared to Mn 2P2O7, due to the substitution effect. The improvement of the electronic and ionic conductivity makes the Ni 0.25Co0.75MnP2O7 nanomaterial possible electrode materials for rechargeable batteries. The electrochemical behaviors of Ni0.25Co0.75MnP2O7 were studied using cyclic voltammetry. © 2013 Published by Elsevier Ltd.

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