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Marchini M.,University of Nice Sophia Antipolis | Charvoz C.,Institute National Of Police Scientifique Inps | Dujourdy L.,Institute National Of Police Scientifique Inps | Baldovini N.,University of Nice Sophia Antipolis | Filippi J.-J.,University of Nice Sophia Antipolis
Journal of Chromatography A

The volatile constituents of drug samples derived from Cannabis sativa L. were investigated by means of headspace solid phase microextraction (HS-SPME) and gas chromatography techniques (GC-MS, GC × GC-MS). Samples of cannabis herb and hashish showed clear differences in their volatile chemical profiles, mostly resulting from photo-oxidation processes occurring during the transformation of fresh cannabis herb into hashish. Most unexpectedly, we could demonstrate hashish samples as containing remarkable amounts of a rare and unusual monoterpene - 5,5-dimethyl-1-vinylbicyclo[2.1.1]hexane - among the volatile compounds detected in their headspaces. We gave evidence for the formation of this compound from the light induced rearrangement of β-myrcene during the manufacture of hashish. In view of its high abundance among volatile constituents of cannabis resin and its scarce occurrence in other natural volatile extracts, we propose to rename this specific monoterpene hashishene. © 2014 Elsevier B.V. Source

Ladroue V.,Institute National Of Police Scientifique Inps | Dujourdy L.,Institute National Of Police Scientifique Inps | Besacier F.,Institute National Of Police Scientifique Inps
Actualite Chimique

Amphetamine is an illicit synthetic drug produced and consumed in Europe. To contribute to fight against illicit trafficking and production of amphetamine, some forensic laboratories use a methodology called profiling which allows links between seizures. Such information can be helpful for operational services and support the dismantling of illicit drugs trafficking networks. A consortium of European forensic laboratories has been set to develop an harmonised analytical method in order to feed a database at European scale and therefore fight trafficking at a supranational level. In France only the Institut National de Police Scientifique (INPS) makes part of this network. The method consists in liquid-liquid extraction of amphetamine impurities followed by gas chromatographic/mass spectrometric analysis. The impurity profiles (abundance of each target compound), that constitute a chemical signature of each production batch, are then registered in a common database and compared in order to link different seizures. This article aims at explaining the concept of profiling and illustrating the various steps required for the development of the European harmonised method for the profiling of amphetamine. Source

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