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Lkhoyaali S.,Institute national doncologie Moulay Abdellah | Benhmida S.,Institute national doncologie Moulay Abdellah | Ait Elhaj M.,Institute national doncologie Moulay Abdellah | Layachi M.,Institute national doncologie Moulay Abdellah | And 2 more authors.
Pathologie Biologie | Year: 2015

Thyroid cancer is an uncommon cancer. Molecular biology plays a vital role in its development. Chemotherapy showed unsatisfactory results in advanced stages where surgery and iodine therapy are not appropriate. These last ten years have been marked by a major advance in understanding the molecular features of this cancer and therapeutic correlations, moreover, clinical trials have focused on the treatment of this disease on metastatic stages and led to a significant therapeutic panel targeting angiogenesis, mutations frequently found in cervical cancer: RET, BRAF, RAS. . . these are the motesanib, axitinib, sunitinib, pazopanib, vandetanib, cabozotinib and sorafenib. The last three molecules have already the autorisation of FDA and EMA. In this review, we will put the item on oncogenetic characteristics of thyroid carcinoma as well as new targeted therapies in patients refractory to conventional treatment. © 2014 Published by Elsevier Masson SAS.

Lkhoyaali S.,Institute National Doncologie Moulay Abdellah | El Haj M.A.,Institute National Doncologie Moulay Abdellah | Khmamouche M.R.,Institute National Doncologie Moulay Abdellah | Berrada N.,Institute National Doncologie Moulay Abdellah | Errihani H.,Institute National Doncologie Moulay Abdellah
Tunisie Medicale | Year: 2015

Background: Announcing cancer to a patient is not a simple task. Usually doctors fail to inform patients about the diagnosis and it is more likely in older people .The need of information in cancerous elderly is not well established. In developed countries, there is evidence that the majority of old patients are demanding exhaustive information about their disease, treatment and prognosis. Aim: In developing countries where social and cultural issues are different, perception of cancer in elderly is not well studied. Therefore we conducted a prospective study on Moroccan elderly cancerous need of information about their disease. Methods: This is a prospective descriptive study, Conducted in the National Institute of Oncology of Morocco, cancerous patients older than 70 were included. A questionnaire was given to participants. Demographics, disease characteristics, social, economical and cultural features were recorded. Results: One hundred and fifty patients responded to the questionnaire. Mean age was 73. 72.7% of patients were diagnosed in advanced stages. Illiteracy was found in 76%. 87.3% of patients did not have health insurance. All patients were Muslim, practicing in 97%. 57% ignored diagnosis. 80% didn't want to know further information about prognosis and treatment side effects. Family protection from information was found in 70%. Conclusion: Moroccan elderly affected with cancer are less demanding of details about their illness.Illiteracy and cultural background may play a major role, Relatives overprotection is also influencing. © 2011 LA TUNISIE MEDICALE. All rights reserved.

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