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Hernandez J.M.,University of Salamanca | Granada I.,Institute Catala dOncologia | Sole F.,Institute Municipal dAssistencia Sanitaria IMAS
Medicina Clinica | Year: 2011

In 1960 Ph-chromosome was found associated with the presence of chronic myelogenous leukemia. In these 50 years an increasing number of cytogenetic abnormalities have been found associated with hematological malignancies. The presence of these abnormalities is not only important for the diagnosis of the patient, but it also contributes to the prognosis of patients with leukemia or lymphoma. For this reason the WHO classification of hematological disease has included these studies for the correct characterization of leukemias and lymphomas. In addition, the use of FISH and micromatrix methodologies have refined the genetic lesions present in these malignancies. The cytogenetic changes observed also provide further information in relation to the therapy. © 2010 Elsevier España, S.L. All rights reserved.


Muniesa J.M.,Institute Municipal dAssistencia Sanitaria IMAS | Marco E.,Institute Municipal dAssistencia Sanitaria IMAS | Tejero M.,Institute Municipal dAssistencia Sanitaria IMAS | Boza R.,Institute Municipal dAssistencia Sanitaria IMAS | And 3 more authors.
Archives of Gerontology and Geriatrics | Year: 2010

The opinion of patients expressed in terms of satisfaction is extremely important in any evaluation of total knee arthroplasty (TKA) results. The primary endpoint of this study was to determine the quantitative and qualitative expectations of elderly patients before undergoing TKA. Cross-sectional study of 497 patients over 65 years was performed before TKA. Main variables collected: demographic, functioning, pain, comorbidity, depression and expectations assessed with the Hospital for Special Knee Replacement Expectation Survey. Statistical tests used were: Student's t-test, analysis of variance, Spearman's ρ and multivariate regression analysis. The means of the total and maximum expectations were 12.3 ± 1.63 and 9.5 ± 1.78 (±S.D.), respectively. Between 90 and 100% of patients referred expectations to improvement regarding pain, basic functional activities (walking, climbing stairs, knee mobility, general mobility) and general well being. There were statistically significant correlations with age (r= -0.321), pain before operation (r= -0.206), expected pain at 6 months (r= -0.206), depressive symptoms (r= -0.180) and the Barthel index (BI) (r= 0.154). One can conclude, that the expectations of improvement among patients before TKA are high and may be classified as expectations of improvement of pain, basic functional activities and general well being. Age, pain intensity and presence of depression correlate inversely with the amount of expectations. © 2010 Elsevier Ireland Ltd.

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