Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anaesthesia - A prospective study [Vliv věku a pohlaví na farmakodynamické vlastnosti rokuronia během totální intravenózní anestezie - Prospektivní studie]
Milan A.,Klinika Anesteziologie |
Lumir H.,Neurochirurgicka Klinika |
Tomas W.,Neurochirurgicka Klinika |
Tomas G.,Klinika Anesteziologie |
And 2 more authors.
Anesteziologie a Intenzivni Medicina | Year: 2012
Objective: To compare the pharmacodynamics of 0.6 mg . kg-1 rocuronium in young and older patients of both genders during total intravenous anaesthesia. Design: Clinical, observational, non-blinded study. Setting: Department of Anaesthesiology, University Hospital.Materials and methods: Following local ethics committee approval and informed consent, patients scheduled for surgery under total intravenous anesthesia (propofol/sufentanil) were divided into 4 study groups: 37 males aged 20-40, 40 males aged 60-75 yrs, 43 females aged 20-40 and 38 females aged 60-75 yrs. Neuromuscular block following rocuronium (0.6 mg kg-1) was monitored as follows: train-of-four [TOF] stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis muscle. The onset time (from application of rocuronium to maximum depression of T1), clinical duration (from application to 25% recovery of T 1), and time to full spontaneous recovery (from application to TOF-ratio ≥ 0.9) were determined for each pa - tient. The Kruskal-Wallis test was used to compare differences between the groups; P < 0.05 was considered statistically significant. Results: The onset time (median [interquartile range]) in the respective groups was 90 [80-110]BCD, 135 [116-165]AC, 75 [60-90]ABD, and 120 [90-146]AC seconds. The clinical duration was 30 [25-42]BCD, 58 [53-67] AD, 50 [40-65]AD, and 85 [70-90]ABC min. The interval to full spontaneous recovery was 59 [51-67]BCD, 102 [75-106]A, 76 [66-91]AD, and 128 [94-137]AC min. (AP<0.05 vs. young males, BP<0.05 vs. elderly males, CP<0.05 vs. young females, DP<0.05 vs. elderly females). Conclusion: Females and the elderly were more sensitive to rocuronium.
Hanakova A.,Institute molekularni a translacni mediciny |
Bogdanova K.,Ustav mikrobiologie |
Tomankova K.,Institute molekularni a translacni mediciny |
Pizova K.,Institute molekularni a translacni mediciny |
And 7 more authors.
Lekar a Technika | Year: 2013
The use of antimicrobial photodynamic therapy (aPDT) as a therapeutic modality for the treatment of localized microbial infections represents an developing new field. The emergence of strains resistant to antibiotics has provided the necessary impulse for new drug or technology discoveries to combat these resistant compounds. Although the aPDT is still in infancy, its need is still growing. Like PDT, main components of antimicrobial photodynamic therapy are appropriate light, dye called photosensitizer and created reactive oxygen species. In this article photosensitizers TMPyP and ZnTPPS4 are investigated for antimicrobial photodynamic therapy. We tested these porphyrins on bacterial methicilin – resistant strain MRSA alone and bound in complex created with hp-β-cyclodextrin. The light emitting diodes (414 nm) were used at the doses 0 and 150 J/cm2. Tested concentrations were from 0.78 to 100 μM. This experimental work predicated that TMPyP is very successful compound in aPDT. In contrary to ZnTPPS4 which was efficient for eradication of tested gram-positive bacteria only in higher concentrations. © 2013, Czech Medical Association J.E. Purkyne. All rights reserved.