Stara Pazova, Serbia
Stara Pazova, Serbia

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Pejin B.,CNR Institute of Biomolecular Chemistry | Iodice C.,CNR Institute of Biomolecular Chemistry | Tommonaro G.,CNR Institute of Biomolecular Chemistry | De Rosa S.,CNR Institute of Biomolecular Chemistry | And 6 more authors.
Current Pharmaceutical Biotechnology | Year: 2014

This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects. © 2014 Bentham Science Publishers.


Pejin B.,University of Belgrade | Kartali T.,University of Novi Sad | Stanimirovic B.,Institute MOL Ltd. | Karaman M.,University of Novi Sad
Asian Journal of Chemistry | Year: 2015

This study aimed to investigate in vitro antibacterial activity of phytol against the selected Gram positive bacteria (Clostridium sporogenes, Enterococcus faecalis and Sarcina lutea) involved in the pathogenesis of infective endocarditis. The examined natural product has proved to be active against all the tested bacteria, but to a varying degree. Indeed, phytol inhibited E. faecalis growth (MIC 1.56 ± 0.04 μg/mL) more effectively than gentamycin and ampicillin (MIC 5.00 ± 0.06 and 16.00 ± 0.03 μg/mL, respectively). Both its freely presence in nutrition and easy availability support the development of a new phytol based medicinal foods targeting heart disease.


Pejin B.,University of Belgrade | Ciric A.,University of Belgrade | Markovic J.D.,University of Belgrade | Glamoclija J.,University of Belgrade | And 3 more authors.
Current Pharmaceutical Biotechnology | Year: 2015

This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/ using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance. © 2015 Bentham Science Publishers.


Pejin B.,University of Belgrade | Pejin B.,CNR Institute of Biomolecular Chemistry | Iodice C.,CNR Institute of Biomolecular Chemistry | Stanimirovic B.,Institute MOL Ltd | And 2 more authors.
Asian Journal of Chemistry | Year: 2014

In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.


Pejin B.,University of Belgrade | Kartali T.,University of Novi Sad | Stanimirovic B.,Institute MOL Ltd | Karaman M.,University of Novi Sad
Asian Journal of Chemistry | Year: 2014

This work extends in vitro screening of antibacterial activity of avarol on four selected pathogenic bacteria associated with psoriasis (Bacillus cereus, Clostridium sporogenes, Enterococcus faecalis and Staphylococcus aureus). Avarol exhibited a moderate activity with minimum inhibitory and minimum bactericidal concentrations ranged from 0.78-1.56 and 3.12-18.75 μg/mL, respectively. It proved to be more effective against B. cereus in comparison to the both positive controls applied, gentamycin and ampicillin. According to the experimental data, this marine natural product may inspire development of new antibiotics with an enhanced therapeutic index, at first place those targeting B. cereus.


Pejin B.,University of Belgrade | Stanimirovic B.,Institute MOL Ltd. | Vujovic D.,University of Belgrade | Popovic Djordjevic J.,University of Belgrade | And 2 more authors.
Natural Product Research | Year: 2016

This work aimed to evaluate the content of selected phenolic natural products in the wine samples made of three new Serbian Cabernet Franc clones (Nos. 02, 010 and 012, respectively) and mother vine (used as the relevant standard) during the period 2008–2012. Compared with all other wine samples, the Cabernet Franc wine of the clone No. 010 was found to have the highest total content of polyphenolics (1.85 ± 0.02 g/L) and anthocyanins (178.55 ± 3.75 mg/L). In addition, its Folin–Ciocalteu index (36.86 ± 0.12) stood out among the examined samples. Finally, the same wine was enriched with ellagic and gallic acids (3.44 ± 0.29 and 27.46 ± 0.21 mg/L, respectively), catechin (135.16 ± 6.47 mg/L) and epicatechin (51.33 ± 2.33 mg/L), the natural products known to exert significant lipid-lowering effects. Taken all together, the clone No. 010 developed in Serbia may offer new Cabernet Franc wine with geographical indication. © 2016 Taylor & Francis

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