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São Benedito do Rio Preto, Brazil

Rooryck C.,University College London | Diaz-Font A.,University College London | Osborn D.P.S.,University College London | Chabchoub E.,University Hospitals of Leuven | And 19 more authors.
Nature Genetics | Year: 2011

3MC syndrome has been proposed as a unifying term encompassing the overlapping Carnevale, Mingarelli, Malpuech and Michels syndromes. These rare autosomal recessive disorders exhibit a spectrum of developmental features, including characteristic facial dysmorphism, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. Here we studied 11 families with 3MC syndrome and identified two mutated genes, COLEC11 and MASP1, both of which encode proteins in the lectin complement pathway (collectin kidney 1 (CL-K1) and MASP-1 and MASP-3, respectively). CL-K1 is highly expressed in embryonic murine craniofacial cartilage, heart, bronchi, kidney and vertebral bodies. Zebrafish morphants for either gene develop pigmentary defects and severe craniofacial abnormalities. Finally, we show that CL-K1 serves as a guidance cue for neural crest cell migration. Together, these findings demonstrate a role for complement pathway factors in fundamental developmental processes and in the etiology of 3MC syndrome. © 2011 Nature America, Inc. All rights reserved. Source


Batista T.P.,Institute Medicina Integral Fernando Figueira | Martins M.R.,HCP Hospital de Pernambuco
Oncology Reviews | Year: 2012

Gastric cancer is one of the most common neoplasms and an important cause of cancer-related death worldwide. Efforts to reduce its high mortality rates are currently focused on multidisciplinary management. However, surgery remains a cornerstone in the management of patients with resectable disease. There is still some controversy as to the extent of lymph node dissection for potentially curable stomach cancer. Surgeons in eastern countries favor more extensive lymph node dissection, whereas those in the West favor less extensive dissection. Thus, extent of lymph node dissection remains one of the most hotly discussed aspects of gastric surgery, particularly because most stomach cancers are now often comprehensively treated by adding some perioperative chemotherapy or chemo-radiation. We provide a critical review of lymph nodes dissection for gastric cancer with a particular focus on its benefits in a multimodal approach. © Copyright T.P. Batista and M.R. Martins, 2012. Source


Ribeiro R.C.,St Jude Childrens Research Hospital | Antillon F.,Francisco Marroquin University | Pedrosa F.,Institute Medicina Integral Fernando Figueira | Pui C.-H.,St Jude Childrens Research Hospital
Journal of Clinical Oncology | Year: 2016

Partnerships between medical institutions in high-income countries (HICs) and low- to mid-income countries (LMICs) have succeeded in initiating and expanding pediatric cancer control efforts. The long-term goal is consistently a sustainable national pediatric cancer program. Here, we review the elements required for successful implementation, development, and long-term sustainability of pediatric cancer programs in LMICs that first arise as partnerships with institutions in HICs. Although plans must be adapted to each country's resources, certain components are unfailingly necessary. First, an essential step is provision of treatment regardless of ability to pay. Second, financial support for program development and long-term sustainability must be sought from sources both international and local, public and private. A local leader, typically a well-trained pediatric oncologist who devotes full-time effort to the project, should direct medical care and collaborate with hospital, governmental, and community leadership and international agencies. Third, nurses must be trained in pediatric cancer care and allowed to practice this specialty full-time. It is also essential to develop a grassroots organization, such as a foundation, dedicated solely to pediatric oncology. Its membersmust be trained and educated to provide pediatric cancer advocacy, fundraising, and (in concert with government) program sustainability. Finally, a project mentor in the HIC is crucial and should explore the possibility of collaborative research in the LMIC, which may offer significant opportunities. Relationships between the partnership's leaders and influential individuals in the community, hospital, grassroots foundation, and government will lay the foundation for productive collaboration and a sustainable pediatric oncology program. © Copyright 2016 American Society of Clinical Oncology. All rights reserved. Source


Oliveira L.C.,Institute Medicina Integral Fernando Figueira | Da Costa A.A.R.,Institute Medicina Integral Fernando Figueira
Revista Brasileira de Terapia Intensiva | Year: 2015

Objective: To analyze the epidemiological clinical profile of women with maternal near miss according to the new World Health Organization criteria. Methods: A descriptive cross-sectional study was conducted, in which the records of patients admitted to the obstetric intensive care unit of a tertiary hospital in Recife (Brazil) over a period of four years were analyzed. Women who presented at least one near miss criterion were included. The variables studied were age, race/color, civil status, education, place of origin, number of pregnancies and prenatal consultations, complications and procedures performed, mode of delivery, gestational age at delivery, and maternal near miss criteria. The descriptive analysis was performed using the program Epi-Info 3.5.1. Results: Two hundred fifty-five cases of maternal near miss were identified, with an overall ratio of maternal near miss of 12.8/1,000 live births. Among these cases, 43.2% of the women had incomplete primary education, 44.7% were primiparous, and 20.5% had undergone a previous cesarean section. Regarding specific diagnoses, there was a predominance of hypertensive disorders (62.7%), many of which were complicated by HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome (41.2%). The laboratory near miss criteria were the most often observed (59.6%), due mainly to the high frequency of acute thrombocytopenia (32.5%). Conclusions: A high frequency of women who had a low level of education and who were primiparous was observed. According to the new criteria proposed by the World Health Organization, hypertensive pregnancy disorders are still the most common among maternal near miss cases. The high frequency of HELLP syndrome was also striking, which contributed to acute thrombocytopenia being the most frequent near miss criterion. Source


De Melo M.C.B.,Instituto Materno Infantil Of Pernambuco | Neto G.H.F.,Instituto Materno Infantil Of Pernambuco | Alchieri J.C.,Federal University of Rio Grande do Norte | Figueiroa J.N.,Institute Medicina Integral Fernando Figueira
Ciencia e Saude Coletiva | Year: 2015

This study consists of the validation of a scale for the analysis of violent behavior in adolescents. It is a cross-sectional observational study. A total of 437 adolescent students from public and private schools in the city of Recife in Pernambuco state participated in the study by responding to a questionnaire. Semantic and Content Validation was performed, followed by Dimensionality, Reliability, Discriminant, Trust and Convergent Analysis. The extraction method was Principal Component Analysis with Varimax rotation and Kaiser normalization. The analysis resulted in a scale for assessment of aggressive behavior of teenagers with 39 items. Seven factors were selected and Cronbach’s total alpha was 0.830. Discriminant analysis revealed groups of items that distinguish subjects between high and low level of violent behavior and between groups of items revealed a positive correlation among 17 items and the reliability of the instrument was confirmed in the retest. The scale revealed evidence of validity as a tool for assessing violent behavior among adolescents. © 2015, Associacao Brasileira de Pos - Graduacao em Saude Coletiva. All rights reserved. Source

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