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Rakotonandrasana O.L.,Institute Malgache des Recherches Appliquees | Raharinjato F.H.,Institute Malgache des Recherches Appliquees | Rajaonarivelo M.,Institute Malgache des Recherches Appliquees | Rajaonarivelo M.,CNRS Natural Product Chemistry Institute | And 4 more authors.
Journal of Natural Products | Year: 2010

In a screening program directed to the discovery of new anticancer agents from Madagascan plants, ethyl acetate extracts of Croton barorum and C. goudotii showed strong cytotoxic activity, with 100% inhibition at 10 μg/mL in a primary screen using the murine lymphocytic leukemia P388 cell line. Bioassay-guided fractionation led to the isolation of two new 3,4-seco-atisane diterpenoids, crotobarin (1) and crotogoudin (2). Their structures were elucidated by spectroscopic data interpretation. Compounds 1 and 2 produced a net progression in the number of cells arrested at the G2/M growth stage in the cell cycle of the K562 human leukemia cell line at 4 μM. © 2010 The American Chemical Society and American Society of Pharmacognosy.

Rakotosaona R.,Institute Malgache des Recherches Appliquees | Nicoletti M.,University of Rome La Sapienza | Papa F.,University of Camerino | Randrianarivo E.,Institute Malgache des Recherches Appliquees | And 2 more authors.
Natural Product Research | Year: 2016

Kaliphora madagascariensis is an evergreen shrub or small tree endemic to Madagascar where it is traditionally used for the treatment of persistent cephalalgia by a strong inhalation of its odour. In this work, we analysed for the first time the essential oil obtained from leaves by Gas Chromatography-Mass Spectrometry. The chemical composition was dominated by oxygenated sesquiterpenes (68.1%), with caryophyllene oxide (14.7%) and β-eudesmol (10.7%) as the most abundant constituents. These compounds are endowed with documented healthy effects such as analgesic, anti-inflammatory, neuritogenic, antiepileptic and hypotensive, and its abundance might explain the traditional use of the plant in Madagascar. © 2015 Taylor & Francis.

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