Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz

San Sebastián de los Reyes, Spain

Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz

San Sebastián de los Reyes, Spain

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Lorenzo O.,Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz | Picatoste B.,Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz | Ares-Carrasco S.,Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz | Ramirez E.,Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz | And 2 more authors.
Mediators of Inflammation | Year: 2011

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis. Copyright 2011 O. Lorenzo et al.


PubMed | Institute Investigaciones Sanitarias IIS Fundacion Jimenez Diaz
Type: | Journal: Mediators of inflammation | Year: 2011

Diabetic cardiomyopathy entails the cardiac injury induced by diabetes independently of any vascular disease or hypertension. Some transcription factors have been proposed to control the gene program involved in the setting and development of related processes. Nuclear factor-kappa B is a pleiotropic transcription factor associated to the regulation of many heart diseases. However, the nuclear factor-kappa B role in diabetic cardiomyopathy is under investigation. In this paper, we review the nuclear factor-kappa B pathway and its role in several processes that have been linked to diabetic cardiomyopathy, such as oxidative stress, inflammation, endothelial dysfunction, fibrosis, hypertrophy and apoptosis.

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