Conde J.,Idis Institute Investigacion Sanitaria Of Santiago |
Scotece M.,Idis Institute Investigacion Sanitaria Of Santiago |
Abella V.,Idis Institute Investigacion Sanitaria Of Santiago |
Abella V.,University of La Coruna |
And 4 more authors.
Expert Review of Clinical Immunology | Year: 2014
Until the discovery of leptin 20 years ago, adipose tissue was considered only as a fat storage organ, involved in the regulation of energy homeostasis. At present, it is well known that adipokines, being leptin the forerunner of this superfamily, may act in different biological processes, including inflammation and immunity. In this review, we have explored the recent evidence about the relationship between leptin and immune system, summarizing the most important findings related to the involvement of leptin in both innate and adaptive immune response. © 2014 Informa UK, Ltd.