Institute Investigacion Sanitaria Of Palma Idispa

Palma, Spain

Institute Investigacion Sanitaria Of Palma Idispa

Palma, Spain
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Yanez A.M.,Institute Investigacion Sanitaria Of Palma Idispa | Yanez A.M.,University of the Balearic Islands | Leiva A.,Institute Investigacion Sanitaria Of Palma Idispa | Leiva A.,Primary Care Research Unit of Mallorca | And 2 more authors.
PLoS ONE | Year: 2017

We examined whether personality traits and parental education are associated with smoking initiation in a sample of Spanish secondary school students. Participants, taken from the ITACA study (842 adolescents aged 14±15 years), completed a questionnaire assessing personality traits of the Five Factor Model, smoking behaviours and parental education. Multinomial logistic regression models controlling for age and sex were used to determine the independent associations and interactions of personality traits and parental education with risk of ever trying smoking, as well as with being a regular smoker in adolescence. Higher conscientiousness was related to a lower chance of trying smoking at least once (OR = 0.57, 95% CIs = 0.46, 0.71) as well as being a regular smoker (OR = 0.39, 95% CIs = 0.27, 0.55). Higher emotional instability (neuroticism) was associated with higher risk of being in either smoking category (OR = 1.33, 95% CIs = 1.10, 1.60 and OR = 1.76, 95% CIs = 1.31, 2.35, respectively). Higher extraversion was also associated with a higher risk of both types of smoking behaviour (OR = 1.38, 95% CIs = 1.12, 1.70 and OR = 2.43 (1.67, 3.55, respectively). Higher parental education was significantly related to lower risk of being a regular smoker (OR = 0.70, 95% CIs = 0.54, 0.89), but not with trying smoking in the past. Finally, we found no evidence of the interactions between adolescents' personality and parental education in predicting adolescent smoking behaviours. We conclude that personality factors and parental education are important and independent factors associated with smoking behaviour in adolescents. © 2017 Yáñez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PubMed | Institute Investigacion Sanitaria Of Palma Idispa
Type: Journal Article | Journal: Atencion primaria | Year: 2016

To describe the current clinical management of insomnia by family physicians.Cross-sectional study.Majorca Health Area, 2011-2012.Family physicians (FP). Paediatricians, resident physicians and emergency physicians were excluded.Using a self-administered questionnaire, the following variables were collected: social, demographic, professional, training in insomnia, prescription preferences, and its clinical management.A total of 322 of 435 physicians answered (74%), of whom 55% were female. The mean age was 48 years with a mean of 21 years in the profession. Most of them consider insomnia as a major health problem, and refer to asking patients about sleep habits and its impact on daily life. About one third have been trained in insomnia in the last 5 years. Very few (0.6%) refers patients to a psychiatrist, and 1.9% to a psychologist. The most prescribed drugs are benzodiazepines (33.4%) and Z drugs (25.7%), with 69.4% of them claiming to have checked the treatment after month of onset. Most refer to advice about sleep hygiene measures (85.1%), 15.1% prescribe herbal remedies, and 14.2% behavioural cognitive therapy (CBT). Seven out of ten physicians consider CBT as effective and applicable by both physicians and nurses. The older FPs prescribe benzodiazepines with less frequency, while female FPs prescribe more sleep hygiene measures and herbal remedies.Most FPs consider insomnia as a major health problem, in which they usually get involved. The most commonly used treatments are sleep hygiene advice, followed by benzodiazepines and Z drugs. The CBT is considered effective but not widely used.

PubMed | j Special Interest Respiratory Area, University of Edinburgh, University of Ferrara, University of Oslo and 10 more.
Type: Journal Article | Journal: The Journal of asthma : official journal of the Association for the Care of Asthma | Year: 2016

Correct inhaler technique is central to effective delivery of asthma therapy. The study aim was to identify factors associated with serious inhaler technique errors and their prevalence among primary care patients with asthma using the Diskus dry powder inhaler (DPI).This was a historical, multinational, cross-sectional study (2011-2013) using the iHARP database, an international initiative that includes patient- and healthcare provider-reported questionnaires from eight countries. Patients with asthma were observed for serious inhaler errors by trained healthcare providers as predefined by the iHARP steering committee. Multivariable logistic regression, stepwise reduced, was used to identify clinical characteristics and asthma-related outcomes associated with 1 serious errors.Of 3681 patients with asthma, 623 (17%) were using a Diskus (mean [SD] age, 51 [14]; 61% women). A total of 341 (55%) patients made 1 serious errors. The most common errors were the failure to exhale before inhalation, insufficient breath-hold at the end of inhalation, and inhalation that was not forceful from the start. Factors significantly associated with 1 serious errors included asthma-related hospitalization the previous year (odds ratio [OR] 2.07; 95% confidence interval [CI], 1.26-3.40); obesity (OR 1.75; 1.17-2.63); poor asthma control the previous 4 weeks (OR 1.57; 1.04-2.36); female sex (OR 1.51; 1.08-2.10); and no inhaler technique review during the previous year (OR 1.45; 1.04-2.02).Patients with evidence of poor asthma control should be targeted for a review of their inhaler technique even when using a device thought to have a low error rate.

PubMed | Institute Investigacion Sanitaria Of Palma Idispa and Son Espases University Hospital
Type: | Journal: OncoTargets and therapy | Year: 2016

Blastic plasmocytoid dendritic cell neoplasm is characterized by aggressive behavior with a tendency for systemic dissemination and a predilection for skin, lymph nodes, soft tissues, peripheral blood, or bone marrow. It usually occurs in elderly patients with a mean age between 60 and 70 years. Despite initial response to chemotherapy, the disease regularly relapses with a short median overall survival. Better outcomes have been reported with high-dose acute leukemia-like induction chemotherapy followed by consolidation with allogeneic hematopoietic stem cell transplantation. However, elderly patients are not candidates for intensive therapy or allogeneic stem cell transplantation. So, new active and tolerable drugs are needed. Our case illustrates that one cycle of lenalidomide and celecoxib provides at least a partial cutaneous and hematologic response, but this regimen was discontinued due to toxicity and followed by a consolidation/maintenance phase with azacitidine, thus achieving a final complete response with a much higher than expected progression-free and overall survival in an elderly patient with comorbidities. This information may be useful in the design of treatment approaches for elderly patients with blastic plasmocytoid dendritic cell neoplasm. However, it should be confirmed in clinical trials as well as by optimizing the induction and extending the consolidation/maintenance period to avoid early relapses after discontinuation and improve progression-free survival.

Mayas J.,Spanish University for Distance Education (UNED) | Parmentier F.B.R.,University of the Balearic Islands | Parmentier F.B.R.,Institute Investigacion Sanitaria Of Palma Idispa | Parmentier F.B.R.,University of Western Australia | And 3 more authors.
PLoS ONE | Year: 2014

A major goal of recent research in aging has been to examine cognitive plasticity in older adults and its capacity to counteract cognitive decline. The aim of the present study was to investigate whether older adults could benefit from brain training with video games in a cross-modal oddball task designed to assess distraction and alertness. Twenty-seven healthy older adults participated in the study (15 in the experimental group, 12 in the control group. The experimental group received 20 1-hr video game training sessions using a commercially available brain-training package (Lumosity) involving problem solving, mental calculation, working memory and attention tasks. The control group did not practice this package and, instead, attended meetings with the other members of the study several times along the course of the study. Both groups were evaluated before and after the intervention using a cross-modal oddball task measuring alertness and distraction. The results showed a significant reduction of distraction and an increase of alertness in the experimental group and no variation in the control group. These results suggest neurocognitive plasticity in the old human brain as training enhanced cognitive performance on attentional functions. © 2014 Mayas et al.

PubMed | Red Cross, Institute Investigacion Sanitaria Of Palma Idispa, GSK, University of Manchester and Queens Medical Research Institute
Type: | Journal: International journal of chronic obstructive pulmonary disease | Year: 2016

Long-acting muscarinic antagonist (LAMA) or long-acting 2-agonist (LABA) bronchodilators and their combination are recommended for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Although the efficacy of LAMAs and LABAs has been well established through randomized controlled trials (RCTs), questions remain regarding their cardiovascular (CV) safety. Furthermore, while the safety of LAMA and LABA monotherapy has been extensively studied, data are lacking for LAMA/LABA combination therapy, and the majority of the studies that have reported on the CV safety of LAMA/LABA combination therapy were not specifically designed to assess this. Evaluation of CV safety for COPD treatments is important because many patients with COPD have underlying CV comorbidities. However, severe CV and other comorbidities are often exclusion criteria for RCTs, contributing to a lack in external validity and generalizability. Real-world observational studies are another important tool to evaluate the effectiveness and safety of COPD therapies in a broader population of patients and can improve upon the external validity limitations of RCTs. We examine what is already known regarding the CV and cerebrovascular safety of LAMA/LABA combination therapy from RCTs and real-world observational studies, and explore the advantages and limitations of data derived from each study type. We also describe an ongoing prospective, observational, comparative post-authorization safety study of a LAMA/LABA combination therapy (umeclidinium/vilanterol) and LAMA monotherapy (umeclidinium) versus tiotropium, with a focus on the relative merits of the study design.

PubMed | Institute Investigacion Sanitaria Of Palma Idispa and Hospital Universitario Son Espases
Type: | Journal: Journal of clinical laboratory analysis | Year: 2016

CyanokitSeveral pools of plasma samples spiked with increasing concentrations of OHCo were prepared. Each one was compared to the pool without interferent. Interference was considered when the bias was more than 10%. An interferograph was developed for those analytes with significant interference. The correlation between interference agent concentration and HI was calculated by Spearman correlation coefficient. We used multiple regression analysis to determine the mathematical correction for amylase, creatinine, and lactate.We detected significant interference in the amylase, carboxyhemoglobin, creatinine, creatine kinase, bilirubin, lactate, and total protein measurement. The HI was positively correlated with OHCo concentration. Corresponding equations for estimating lactate and creatinine concentrations were obtained.OHCo interferes with many laboratory assays in an unpredictable way making some results invalid and confounding clinical decision making. We can detect and evaluate the degree of interference with the HI. We can still estimate real creatinine and lactate levels using the regression equation obtained in this study.

Leiva A.,University of the Balearic Islands | Leiva A.,Institute Investigacion Sanitaria Of Palma Idispa | Parmentier F.B.R.,University of the Balearic Islands | Parmentier F.B.R.,Institute Investigacion Sanitaria Of Palma Idispa | And 3 more authors.
Experimental Psychology | Year: 2015

We report the results of oddball experiments in which an irrelevant stimulus (standard, deviant) was presented before a target stimulus and the modality of these stimuli was manipulated orthogonally (visual/auditory). Experiment 1 showed that auditory deviants yielded distraction irrespective of the target's modality while visual deviants did not impact on performance. When participants were forced to attend the distractors in order to detect a rare target ("target-distractor"), auditory deviants yielded distraction irrespective of the target's modality and visual deviants yielded a small distraction effect when targets were auditory (Experiments 2 & 3). Visual deviants only produced distraction for visual targets when deviant stimuli were not visually distinct from the other distractors (Experiment 4). Our results indicate that while auditory deviants yield distraction irrespective of the targets' modality, visual deviants only do so when attended and under selective conditions, at least when irrelevant and target stimuli are temporally and perceptually decoupled. © 2014 Hogrefe Publishing.

Parmentier F.B.R.,University of the Balearic Islands | Parmentier F.B.R.,Institute Investigacion Sanitaria Of Palma Idispa | Parmentier F.B.R.,University of Western Australia | Kefauver M.,University of the Balearic Islands
Brain Research | Year: 2015

Rare changes in a stream of otherwise repeated task-irrelevant sounds break through selective attention and disrupt performance in an unrelated visual task. This deviance distraction effect emerges because deviant sounds violate the cognitive system's predictions. In this study we sought to examine whether predictability also mediate the so-called semantic effect whereby behavioral performance suffers from the clash between the involuntary semantic evaluation of irrelevant sounds and the voluntary processing of visual targets (e.g.; when participants must categorize a right visual arrow following the presentation of the deviant sound "left"). By manipulating the conditional probabilities of the congruent and incongruent deviant sounds in a left/right arrow categorization task, we elicited implicit predictions about the upcoming target and related response. We observed a linear increase of the semantic effect with the proportion of congruent deviant trials (i.e.; as deviant sounds increasingly predicted congruent targets). We conclude that deviant sounds affect response times based on a combination of crosstalk interference and two types of prediction violations: stimulus violations (violations of predictions regarding the identity of upcoming irrelevant sounds) and semantic violations (violations of predictions regarding the target afforded by deviant sounds). We report a three-parameter model that captures all key features of the observed RTs. Overall, our results fit with the view that the brain builds forward models of the environment in order to optimize cognitive processing and that control of one's attention and actions is called upon when predictions are violated. This article is part of a Special Issue entitled SI: Prediction and Attention. © 2015 Elsevier B.V.

Lopez-Gonzalez A.A.,Servicio Of Prevencion Of Riesgos Laborales | Bennasar-Veny M.,University of the Balearic Islands | Tauler P.,University of the Balearic Islands | Aguilo A.,University of the Balearic Islands | And 2 more authors.
Gaceta Sanitaria | Year: 2015

Objective: To describe the cardiovascular risk factors in a working population in the Balearic Islands and to examine whether differences by social class vary according to age and gender. Methods: A cross-sectional study was carried out in a sample of active workers aged 20-65 years in the Balearic Islands. The participants were included in the study during their annual work health assessment in 2011. The following variables were collected: occupation, social class, age, gender, height, weight, smoking, blood pressure, lipid profile, and glucose levels. Cardiovascular risk was calculated using two different equations (Framingham and REGICOR). Results: Differences by social class were observed for most cardiovascular risk factors. The pattern of these differences differed depending on age group and gender. Differences in obesity by social class increased with age in women but decreased in men. More differences in hypertension by social class were found among women than among men, with differences increasing with age in both genders. Significant differences by social class were found among women in lipid profile, and these differences increased with age, mainly for low levels of high-density lipoprotein-cholesterol. Conclusions: Inequalities in cardiovascular risk factors by social class were higher among women than among men. Some cardiovascular risk factors such as smoking and obesity showed significant inequalities from a very early age. © 2014 SESPAS.

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