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Juan D. Unciti-Broceta,Institute Investigacion Biosanitaria Of Granada Ibig | Juan D. Unciti-Broceta,Institute Investigacion Biosanitaria Of Granada Ibig | Jose MacEira,Institute Investigacion Biosanitaria Of Granada Ibig | Jose MacEira,Institute Investigacion Biosanitaria Of Granada Ibig | And 7 more authors.
Journal of Biological Chemistry | Year: 2013

Background: Nicotinamide is a soluble compound of the vitamin B3 group with antimicrobial activity. Results: Nicotinamide causes disruption of the lysosome and inhibits the cathepsin b-like enzyme, an essential lysosomal protease in trypanosomatids. Conclusion: Nicotinamide kills African trypanosomes by targeting the cathepsin b-like protease. Significance: These results demonstrate for the first time the inhibitory effect of nicotinamide on a protease. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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