Institute Investigacion Biomedica Of Malaga

Torremolinos, Spain

Institute Investigacion Biomedica Of Malaga

Torremolinos, Spain

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Gomez-Zumaquero J.L.,Institute Investigacion Biomedica Of Malaga
Tissue Antigens | Year: 2013

Two novels alleles, HLA-A*01:128 and HLA-C*05:88 are characterized. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Gutierrez-Sacristan A.,GRIB | Bravo A.,GRIB | Portero M.,GReNeC | Valverde O.,GReNeC | And 19 more authors.
CEUR Workshop Proceedings | Year: 2016

During the last years there has been a growing research in the genetics of psychiatric diseases. However, there is still a limited understanding of the cellular and molecular mechanisms leading to these diseases, which has hampered the application of this wealth of knowledge into the clinical practice to improve diagnosis and treatment of psychiatric patients. PsyGeNET (http:// www.psygenet.org/) has been developed to improve the understanding of psychiatric diseases, by facilitating the access to the vast amount of their genetic information in a structured manner, providing a set of analysis and visualization tools. In this communication we describe the protocol we put in place for the sustainable update of this knowledge resource. It includes the recruitment of a team of experts to perform the curation of the data previously extracted by text mining. Annotation guidelines and a webbased annotation tool were developed to support curators tasks. A curation workflow was designed including a pilot phase, and two rounds of curation and analysis phases. We report the results of the application of this workflow to the task of curation of gene-disease associations for PsyGeNET, including the analysis of the inter-annotator agreement, and suggest that this model is a suitable approach for the sustainable development and update of knowledge resources.


Bellon J.A.,University of Malaga | Bellon J.A.,Institute Investigacion Biomedica Of Malaga | Moreno-Peral P.,Institute Investigacion Biomedica Of Malaga | Moreno-Kustner B.,University of Malaga | And 11 more authors.
PLoS ONE | Year: 2014

Background: The predictD study developed and validated a risk algorithm for predicting the onset of major depression in primary care. We aimed to explore the opinion of patients about knowing their risk for depression and the values and criteria upon which these opinions are based. Methods: A maximum variation sample of patients was taken, stratified by city, age, gender, immigrant status, socioeconomic status and lifetime depression. The study participants were 52 patients belonging to 13 urban health centres in seven different cities around Spain. Seven Focus Groups (FGs) were given held with primary care patients, one for each of the seven participating cities. Results: The results showed that patients generally welcomed knowing their risk for depression. Furthermore, in light of available evidence several patients proposed potential changes in their lifestyles to prevent depression. Patients generally preferred to ask their General Practitioners (GPs) for advice, though mental health specialists were also mentioned. They suggested that GPs undertake interventions tailored to each patient, from a "patient-centred" approach, with certain communication skills, and giving advice to help patients cope with the knowledge that they are at risk of becoming depressed. Conclusions: Patients are pleased to be informed about their risk for depression. We detected certain beliefs, attitudes, values, expectations and behaviour among the patients that were potentially useful for future primary prevention programmes on depression. © 2014 Bellón et al.


Caro-Bautista J.,Institute Investigacion Biomedica Of Malaga | Morilla-Herrera J.C.,University of Malaga | Villa-Estrada F.,Institute Investigacion Biomedica Of Malaga | Cuevas-Fernandez-Gallego M.,University of Malaga | And 2 more authors.
Atencion Primaria | Year: 2015

Objective: To undertake the cultural adaptation and the psychometric assessment of the Summary of Diabetes Self-Care Activities measure (SDSCA) in Spanish population with type 2 diabetes mellitus. Design: Clinimetric validation study. Setting: Primary health care centers of District Malaga and Valle del Guadalhorce. Participants: Three hundred thirty-one persons with type 2 diabetes mellitus. Main measurements: The SDSCA validated in mexican population was subjected to semantic and content equivalence using a Delphi method, its legibility was determined by INFLESZ scale. Subsequently psychometric validation was conducted through exploratory and confirmatory factor analysis (herein after EFA and CFA), internal consistency, test-retest reliability and discriminant validity. Results: Two rounds were needed to achieve the consensus in between the panel members. Then, the index provided a good readability. The EFA suggested a model with 3 factors (diet, exercise and self-analysis) with 7 items which explained 79.16% variance. The results of CFA showed a good fit of SDSCA-Sp. The Internal consistency was moderate to low (α-Cronbach =0.62) and test-retest reliability was evaluated in 198 patients (t = 0.462-0.796, p. <. 0.001) with a total correlation of 0.764 (p< 0.0001). Conclusions: The SDSCA-Sp is used, in a valid way to assess self-care in type 2 DM version in clinical practice and research with similar clinimetric properties to previous studies. © 2015 Elsevier España, S.L.U.


Rueda A.,Institute Investigacion Biomedica Of Malaga | Olmos D.,CSIC - National Center for Metallurgical Research | Vicioso L.,Hospital Universitario Virgen Of La Victoria | Quero C.,Hospital Universitario Virgen Of La Victoria | And 7 more authors.
Leukemia and Lymphoma | Year: 2015

We performed three different studies to obtain additional data on the biological and prognostic role of vascular endothelial growth factor C (VEGFC) in classical Hodgkin lymphoma (cHL): (1) serum VEGFC levels were measured by enzyme-linked immunosorbent assay in 80 patients; (2) immunohistochemical VEGFC expression in tumor tissue was evaluated using a case-control study in 62 patients; (3) gene expression of VEGFC was investigated in vitro in six cHL cell lines, and was compared with expression in inflammatory lymph nodes. Higher serum VEGFC levels were found in patients with cHL than in healthy volunteers (median, 7675 vs. 1358 pg/mL, p < 0.001) and high VEGFC expression in tissue predicted worse progression-free survival at 7 years (41% vs. 91%, p < 0.0001). VEGFC expression in all Hodgkin lymphoma cell lines was higher than the mean expression level in inflammatory lymph nodes. Our data suggest that Hodgkin and Reed-Sternberg cells produce VEGFC, and VEGFC expression could be a novel prognostic factor in cHL. © 2015 Informa UK, Ltd.


PubMed | Institute Investigacion Biomedica Of Malaga and University of Malaga
Type: Journal Article | Journal: Atencion primaria | Year: 2016

To undertake the cultural adaptation and the psychometric assessment of the Summary of Diabetes Self-Care Activities measure (SDSCA) in Spanish population with type 2 diabetes mellitus.Clinimetric validation study.Primary health care centers of District Malaga and Valle del Guadalhorce.Three hundred thirty-one persons with type 2 diabetes mellitus.The SDSCA validated in mexican population was subjected to semantic and content equivalence using a Delphi method, its legibility was determined by INFLESZ scale. Subsequently psychometric validation was conducted through exploratory and confirmatory factor analysis (herein after EFA and CFA), internal consistency, test-retest reliability and discriminant validity.Two rounds were needed to achieve the consensus in between the panel members. Then, the index provided a good readability. The EFA suggested a model with 3 factors (diet, exercise and self-analysis) with 7 items which explained 79.16% variance. The results of CFA showed a good fit of SDSCA-Sp. The Internal consistency was moderate to low (-Cronbach =0.62) and test-retest reliability was evaluated in 198 patients (t=0.462-0.796, p<0.001) with a total correlation of 0.764 (p< 0.0001).The SDSCA-Sp is used, in a valid way to assess self-care in type 2 DM version in clinical practice and research with similar clinimetric properties to previous studies.


Perez I.,Hospital Universitario Virgen Of La Victoria | Moreno T.,Hospital Universitario Virgen Of La Victoria | Navarro F.,Hospital Universitario Virgen Of La Victoria | Santos J.,Hospital Universitario Virgen Of La Victoria | And 3 more authors.
International Journal of STD and AIDS | Year: 2013

To determine the prevalence of erectile dysfunction and its associated factors we conducted an observational study on a consecutive cohort of asymptomatic HIV-positive men. All the patients completed a questionnaire to evaluate erectile dysfunction based on the International Index of Erectile Function, a validated survey for the diagnosis of anxiety and depression (self-administered HAD), and a questionnaire about cardiovascular risk factors. Epidemiological, clinical, and analytical data were collected. In all, 158 men, participated: mean age 46.0 years, 96.2% on antiretroviral therapy (91.3% undetectable viral load), and the mean CD4 count was 534 cells/mL. Erectile dysfunction was present in 106 (67.1%) patients, and associated factors were age (OR 4.5 for each 5 years; 95% CI 4.3-4.7; p = 0.0001) and anxiety (OR 8.2, 95% CI 2.2-30.4; p = 0.002). The prevalence of erectile dysfunction is high in men living with HIV, even in those with good immunovirological control. It is related to increasing age and anxiety, both of which are important factors within our HIV cohort. © The Author(s) 2013.

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