Institute Investigacion Biologica del Paraguay

Ciudad del Este, Paraguay

Institute Investigacion Biologica del Paraguay

Ciudad del Este, Paraguay

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Entiauspe-Neto O.M.,Instituto Federal Of Educacao | de Lema T.,Grande Rio University | Beconi H.E.C.,Institute Investigacion Biologica del Paraguay
Check List | Year: 2014

The fossorial snake Apostolepis intermedia is an Elapomorphini species currently known by two specimens from Brazil. In this study, we report the first records of the species in Paraguay, based on two female specimens from the Reserva Natural Laguna Blanca, Departamento San Pedro, Paraguay. These records occurred 376 km south from the previously southernmost record, in Anastácio, Mato Grosso do Sul, Brazil. We also provide data on the species morphological variation. © 2014 Check List and Authors.


PubMed | Chilean Center of Nanosciences and Nanotechnology, Institute Investigacion Biologica del Paraguay, University of Talca and University of Chile
Type: | Journal: Journal of ethnopharmacology | Year: 2017

Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections.The objective of the study was to determine the composition of venoms obtained from three different Paraguayan Rhinella species, to establish the constituents of a preparation sold in the capital city of Paraguay to treat cancer as containing the toad as ingredient, to establish the effect of the most active Rhinella schneideri venom on the cell cycle using human breast cancer cells and to assess the antiprotozoal activity of the venoms.The venom obtained from the toads parotid glands was analyzed by HPLC-MS-MS. The preparation sold in the capital city of Paraguay to treat cancer that is advertised as made using the toad was analyzed by HPLC-MS-MS. The effect of the R. schneideri venom and the preparation was investigated on human breast cancer cells. The antiprotozoal activity was evaluated on Leishmania braziliensis, L. infantum and murine macrophages.From the venoms of R. ornata, R. schneideri and R. scitula, some 40 compounds were identified by spectroscopic and spectrometric means. Several minor constituents are reported for the first time. The preparation sold as made from the toad did not contained bufadienolides or compounds that can be associated with the toad but plant compounds, mainly phenolics and flavonoids. The venom showed activity on human breast cancer cells and modified the cell cycle proliferation. The antiprotozoal effect was higher for the R. schneideri venom and can be related to the composition and relative ratio of constituents compared with R. ornata and R. scitula.The preparation sold in the capital city of Paraguay as containing the toad venom, used popularly to treat cancer did not contain the toad venom constituents. Consistent with this, this preparation was inactive on proliferation of human breast cancer cells. In contrast, the toad venoms of Rhinella species altered the cell cycle progression, affecting the proliferation of malignant cells. The findings suggest that care should be taken with the providers of the preparation and that the crude drug present a strong activity towards human breast cancer cell lines. The antiprotozoal effect of the R. schneideri venom was moderate while the venom of R. ornata was devoid of activity and that of R. scitula was active at very high concentration.


Brusquetti F.,Paulista University | Brusquetti F.,Institute Investigacion Biologica del Paraguay | Jansen M.,Senckenberg Forschungsinstitut und Naturmuseum | Barrio-Amoros C.,Institute Biodiversidad Tropical | And 2 more authors.
Zoological Journal of the Linnean Society | Year: 2014

Scinax fuscomarginatus, Scinax parkeri, Scinax trilineatus, Scinax lutzorum, and Scinax pusillus are morphologically similar species with controversial taxonomy associated with open formations of South America east of the Andes. We used external morphology, advertisement call, and molecular sequences to assess the taxonomy of these species. Phylogenetic analysis of molecular data showed a well-supported monophyletic group divided into two main clades and several subclades. Specimens of Hyla madeirae (synonym of S.fuscomarginatus) and those from Serra do Cachimbo correspond to distinct subclades, whereas the currently valid species were grouped into a single clade. This clade showed a marked substructure, but concordance of the recognized species to subclades was limited, showing S.fuscomarginatus to be paraphyletic with respect to S.parkeri, S.trilineatus, S.lutzorum, and S.pusillus. The high intrapopulation and intraspecific variation found in morphological characters did not allow us to differentiate amongst the currently recognized species. Similarly, none of them was distinguishable by morphometric analysis or advertisement call. Based on multiple evidence, we propose the synonymy of S.parkeri, S.trilineatus, S.lutzorum, and S.pusillus with S.fuscomarginatus, the revalidation of H. madeirae, and describe the specimens from Serra do Cachimbo as a new species. © 2014 The Linnean Society of London.


Brusquetti F.,Claro | Brusquetti F.,Institute Investigacion Biologica Del Paraguay | Thome M.T.C.,Claro | Canedo C.,Federal University of Rio de Janeiro | And 2 more authors.
Herpetologica | Year: 2013

Here we describe a new species of the Ischnocnema parva species series from the Parque Estadual do Desengano, in the northern part of the State of Rio de Janeiro, Brazil. We use morphology and mtDNA sequences to allocate the new species into the I. parva species series. The new species is closely related to I. parva genetically and morphologically, from which it is diagnosable by (1) the presence of a well-developed calcar tubercle, (2) a reduced Toe I, (3) a deep V-shaped median slit on the dorsal surface of toe discs, and (4) externally indistinct tympanum and tympanic annulus. © 2013 by The Herpetologists' League, Inc.


Cacciali P.,Para La Tierra | Cacciali P.,Institute Investigacion Biologica del Paraguay | Smith P.,Para La Tierra | Kallberg A.,Para La Tierra | And 2 more authors.
Check List | Year: 2013

The first Paraguayan records of the poorly known xenodontine snake Lygophis paucidens are reported. Two male specimens were collected in a mosaic habitat of Campo Sucio and Cerrado sensu stricto in the Reserva Natural Laguna Blanca, Departamento San Pedro. This is the first record of this species outside of Brazil. © 2013 Check List and Authors.


Cacciali P.,Senckenberg Forschungsinstitut und Naturmuseum Frankfurt | Cacciali P.,Institute Investigacion Biologica Del Paraguay | Scott N.J.,Smithsonian Institution
Zootaxa | Year: 2015

Ophiodes is a South American genus of legless diploglossid lizards. Four species have been formally described: O. inter-medius, O. vertebralis, O. striatus, and O. fragilis; three additional species were described but not officially named in an unpublished dissertation. These species are referred to as Ophiodes sp. "1", Ophiodes sp. "2", and Ophiodes sp. "3". We recognize five species of Ophiodes in Paraguay, one widespread (O. intermedius) and four known from only one or two localities (O. fragilis, O. striatus, O. sp. "3", and an undescribed species, described herein). The new species described represents the fifth Paraguayan species and the eighth member of the genus. It is distinguished by a combination of the following characters: a high number of middorsal scales between occipital and cloacal opening (>165), 29 scale rows around midbody, the posterior limbs 4 scales long, and vertical black bars on the face absent. Copyright © 2015 Magnolia Press.


Cacciali P.,Institute Investigacion Biologica del Paraguay | Cacciali P.,Senckenberg Forschungsinstitut und Naturmuseum | Cabral H.,Institute Investigacion Biologica del Paraguay
Basic and Applied Herpetology | Year: 2015

Chironius is a genus of slender snakes adapted to a diurnal and arboreal life style, and is distributed from Honduras to Uruguay inhabiting different environments. Five species are present in Paraguay: C. bicarinatus, C. exoletus, C. flavolineatus, C. maculoventris, and C. quadricarinatus. In this work, we provide data on distribution, coloration, and morphological variation of 20 Paraguayan specimens housed in scientific collections. Our results fit with known parameters for the species referred in literature. A conclusion of this work is that, based on distribution and ecological preferences of the species in the region, Paraguay is poorly sampled. Here we extend the known pholidosis range of ventral scale for females of C. bicarinatus (154-170), and for C. maculoventris (143-157 for females and 154-161 for males), and the range of subcaudal scales for males of C. maculoventris (90-125), and females of C. quadricarinatus (91-123). © Asociacion Herpetologica Espanola. All rights reserved.


Cacciali P.,University of the Republic of Uruguay | Cacciali P.,Institute Investigacion Biologica del Paraguay
Acta Herpetologica | Year: 2010

Xenodon merremi is a polychromatic species distributed in South America. Among its wide range of color patterns, the most common pattern resembles a pitviper of the genus Bothrops. In this work is recorded the different patterns found in Paraguayan populations of X. merremi. Four patterns can be observed: marked pattern, slightly marked pattern, smooth, and banded pattern. The marked pattern is the most common pattern (mimetic with pitvipers), and all juveniles bear this coloration. Only adults show variation in their coloration. © Firenze University Press.


Beconi H.C.,Asociacion Guyra Paraguay | Beconi H.C.,Institute Investigacion Biologica del Paraguay | Scott N.J.,Smithsonian Institution
Check List | Year: 2014

We present the first record of Oxyrhopus petolarius for Departamento Itapúa, Paraguay. This record extends the species known distribution in approximately 166 km southwest from Puerto Bertoni in Departamento Alto Paraná, representing the southernmost record for the species and highlights the importance of protecting the remaining Atlantic Forest patches in Paraguay. © 2014 Check List and Authors.


Cabral H.,Asociacion Guyra Paraguay | Cabral H.,Institute Investigacion Biologica Del Paraguay | Cacciali P.,Institute Investigacion Biologica Del Paraguay | Cacciali P.,Senckenberg Forschungsinstitut und Naturmuseum
Herpetologica | Year: 2015

Phalotris is a genus of Neotropical snakes with secretive habits that is poorly represented in collections. We describe a new species of Phalotris belonging to the bilineatus group from near Filadelfia in the Dry Chaco of Paraguay. The new species differs from P. lemniscatus and P. spegazzinii by having wider white and black neck collars, a wider black transverse ring in the anal region, and different coloration of the black dorsolateral lines. It differs from P. multipunctatus in the presence of a caudal ring, wider white and black neck collars, and having the entire head black without white marks. In addition, the new species is the only member of the bilineatus group with the black ventral coloration reduced to scattered dots. The new species is described based on three road-killed specimens found since 1995. The new species is currently considered endemic to xerophytic areas of the Paraguayan Chaco. Five species of Phalotris are now known to occur in Paraguay. © 2015 The Herpetologists' League, Inc.

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