Institute Investigacao Cientifica Bento da Rocha Cabral

Lisbon, Portugal

Institute Investigacao Cientifica Bento da Rocha Cabral

Lisbon, Portugal

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Matos A.,University of Lisbon | Marinho-Dias J.,Portuguese Institute of Oncology Porto Center | Marinho-Dias J.,Abel Salazar Biomedical Sciences Institute | Ramalheira S.,Portuguese Institute of Oncology Porto Center | And 4 more authors.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2016

A solid body of knowledge indicates that overweight and obese subjects are prone to develop cancer, aggressive disease, and death more than their lean counterparts. While obesity has been causally associated with various cancers, only a limited number of studies beheld the link with classical Hodgkin lymphoma (HL). Contemporary meta-analysis and prospective studies confirmed the association of body mass index with HL. Besides epidemiological evidence, excess adiposity is known to influence tumor behavior through adipokines, adipose-derived stem cell migration, and metabolism regulation, and by modulating immunoinflammatory response. Nevertheless, the obesity paradox has been described in few cancers. Considering that adipose tissue is an immunomodulatory organ, and that inflammation is the cornerstone of HL pathophysiology, the rationale for being causally related due to endocrine/paracrine interactions cannot be negligible. In this hypothesis-generating review, we explore the biologically plausible links between excess adiposity and HL in light of recent basic and clinical data, in order to create a basis for understanding the underlying mechanisms and foster applied research. The establishment of an association of excess adiposity with HL will determine public health preventive measures to fight obesity and eventually novel therapeutic approaches in HL patients.


Aguiar L.,University of Lisbon | Aguiar L.,Institute Investigacao Cientifica Bento da Rocha Cabral | Matos A.,University of Lisbon | Matos A.,Institute Investigacao Cientifica Bento da Rocha Cabral | And 12 more authors.
Clinical Hemorheology and Microcirculation | Year: 2016

BACKGROUND: Sickle cell anemia (SCA) is an inherited blood disorder. SCA patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene. Others genetic modifiers and environmental effects are important for the clinical phenotype. SCA patients present arginine deficiency that contributes to a lower nitric oxide (NO) bioactivity. OBJECTIVE: The aim of this work is to determine the association between hematological and biochemical parameters and genetic variants from eNOS gene, in pediatric SCA patients. METHODS: 26 pediatric SCA patients were genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques in three important eNOS gene polymorphisms - rs2070744, rs1799983 and intron 4 VNTR. RESULTS: Results from this study show a significant statistical association between some parameters and genetic variants: an increased reticulocyte count and high serum lactate dehydrogenase levels were associated with both the rs2070744-TT and the rs1799983-GG genotypes at eNOS gene and high levels of neutrophils were associated with the eNOS4a allele at intron 4 VNTR. CONCLUSIONS: Our results reinforce the importance of NO bioactivity in SCA. We presume that NO, and its precursors might be used as therapy to improve the quality of life of SCA patients. © 2016 - IOS Press and the authors. All rights reserved.


Matos A.,University of Lisbon | Matos A.,Institute Investigacao Cientifica Bento da Rocha Cabral | Castelao C.,University of Lisbon | Pereira Da Silva A.,University of Lisbon | And 6 more authors.
Oxidative Medicine and Cellular Longevity | Year: 2016

There is a clear association between the excessive and cumulative exposure to estrogens and the development of cancer in hormone-sensitive tissues, such as the cervix. We studied the association of CYP1A1 M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls. The CYP1A1 TT genotype was associated with a lower risk for c-cancer (OR = 0.39, p=0.002). The allele C of CYP1A1 was a risk for c-cancer (OR = 2.29, p=0.002). Women with COMT LL genotype had a higher risk of developing c-cancer (OR = 4.83, p<0.001). For the interaction of the CYP1A1&COMT, we observed that TC&HL genotypes had a greater risk for c-cancer (OR = 6.07, p=0.006) and TT&HL genotypes had a protection effect (OR = 0.24, p<0.001). The CYP1A1 TT and COMT LL genotypes had higher estradiol levels in c-cancer (p<0.001 and p=0.037, resp.). C-cancer is associated with less production of 2-methoxy-estradiol resultant of functional polymorphisms of CYP1A1 and COMT, separately. CYP1A1 and COMT work in a metabolic sequence and their interaction could lead to an alternative pathway of estrogen metabolism with production of 16-OH-estrone that is more proliferative. © 2016 Andreia Matos et al.


Brilhante M.F.,University of The Azores | Brilhante M.F.,University of Lisbon | Pestana D.,University of Lisbon | Pestana D.,Institute Investigacao Cientifica Bento da Rocha Cabral | And 2 more authors.
AIP Conference Proceedings | Year: 2015

The family Xm, m ε [-2, 2], whose density is obtained tilting the uniform density using the pole (0.5, 1) has as extreme cases the Beta(1, 2) density, corresponding to m=-2, and the Beta(2, 1) density, corresponding to m=2. For intermediate m, the density mixes the uniform density (m=0) with one of the extreme cases. It is therefore an appropriate model for reported p-values when the best, or worst, of two replica is recorded whenever the result of the experiment is unexpected. Estimation of the mixing parameter is discussed. © 2015 AIP Publishing LLC.


Brilhante M.F.,University of The Azores | Brilhante M.F.,University of Lisbon | Pestana D.,CEAUL | Pestana D.,Institute Investigacao Cientifica Bento da Rocha Cabral
AIP Conference Proceedings | Year: 2015

The BetaBoop(p, q, P, Q), p, q, P, Q > 0, family of random variables includes as special cases Beta(p, q) random variables, which are known to be quite versatile in modeling different randomness patterns. Some results of the multiplicative algebra of BetaBoop random variables are commented in the light of uniform order statistics. Products and products of powers and of random powers of independent standard uniforms are also investigated, namely when the exponent is either uniform or the maximum of an uniform random sample, or its probability density function is a mixture of the uniform density and the density of an extreme of two independent uniform random variables. © 2015 AIP Publishing LLC.


Matos A.,University of Lisbon | Matos A.,Institute Investigacao Cientifica Bento da Rocha Cabral | Marinho-Dias J.,Portuguese Institute of Oncology Porto Center | Marinho-Dias J.,Abel Salazar Biomedical Sciences Institute | And 7 more authors.
Tumor Biology | Year: 2016

A solid body of knowledge indicates that overweight and obese subjects are prone to develop cancer, aggressive disease, and death more than their lean counterparts. While obesity has been causally associated with various cancers, only a limited number of studies beheld the link with classical Hodgkin lymphoma (HL). Contemporary meta-analysis and prospective studies confirmed the association of body mass index with HL. Besides epidemiological evidence, excess adiposity is known to influence tumor behavior through adipokines, adipose-derived stem cell migration, and metabolism regulation, and by modulating immunoinflammatory response. Nevertheless, the obesity paradox has been described in few cancers. Considering that adipose tissue is an immunomodulatory organ, and that inflammation is the cornerstone of HL pathophysiology, the rationale for being causally related due to endocrine/paracrine interactions cannot be negligible. In this hypothesis-generating review, we explore the biologically plausible links between excess adiposity and HL in light of recent basic and clinical data, in order to create a basis for understanding the underlying mechanisms and foster applied research. The establishment of an association of excess adiposity with HL will determine public health preventive measures to fight obesity and eventually novel therapeutic approaches in HL patients. © 2016 International Society of Oncology and BioMarkers (ISOBM)


Pestana D.,University of Lisbon | Pestana D.,Institute Investigacao Cientifica Bento da Rocha Cabral
Acta Medica Portuguesa | Year: 2013

Statistics is a privileged tool in building knowledge from information, since the purpose is to extract from a sample limited information conclusions to the whole population. The pervasive use of statistical software (that always provides an answer, the question being adequate or not), and the absence of statistics to confer a scientific flavour to so much bad science, has had a pernicious effect on some disbelief on statistical research. Would Lord Rutherford be alive today, it is almost certain that he would not condemn the use of statistics in research, as he did in the dawn of the 20th century. But he would indeed urge everyone to use statistics quantum satis, since to use bad data, too many data, and statistics to enquire on irrelevant questions, is a source of bad science, namely because with too many data we can establish statistical significance of irrelevant results. This is an important point that addicts of evidence based medicine should be aware of, since the meta analysis of two many data will inevitably establish senseless results. © Ordem dos Médicos 2013.


Castaldo S.A.,University of Lisbon | Castaldo S.A.,Institute Medicina Molecular | da Silva A.P.,University of Lisbon | Matos A.,University of Lisbon | And 8 more authors.
Tumor Biology | Year: 2015

Human papillomavirus (HPV) infection is necessary but not a sufficient cause for the development of invasive cervical cancer (ICC). Epithelial tissues, target for HPV, are exposed to reactive oxygen species (ROS) associated with tumor initiation and progression. The NADPH oxidase (NOX) and catalase (CAT) are involved in hydrogen peroxide (H2O2) production and inactivation, respectively. P22phox is the NOX subunit encoded by the CYBA gene that has a functional polymorphism (C-242T). This protein is involved in the regulation of electron transfer to oxygen. CAT is a hemic enzyme that plays a role in regulating H2O2 concentration, with a functional polymorphism (C-262T) in its gene. We evaluated CYBA C-242T and CAT C262T genetic polymorphisms and their interaction in 132 women with ICC. We found that CYBA C-242T and CAT C262T genotype frequencies were significantly different between ICC and controls (χ2 test, p = 0.017 and p = 0.009, respectively). Women with the C/T CYBA-242 genotype had a lower risk for ICC development (odds ratio (OR) = 0.515, 95 % confidence interval (CI) 0.291–0.914, p = 0.023) whereas T/T CAT-262 genotype carriers present an increased risk for ICC (OR = 3.034, 95 % CI 1.462–6.298, p = 0.003). Women with C/C genotype for CYBA and T/T genotype for CAT had an increased risk to develop ICC comparing with the interaction of the other possible genotypes of both genes (OR = 3.952, 95 % CI 1.075–14.521, p = 0.032). The CYBA C-242T and CAT C-262T genetic polymorphisms and their epistatic interactions can be associated with ICC through mechanisms related with the role of ROS in cell proliferation and apoptosis. © 2014, International Society of Oncology and BioMarkers (ISOBM).


PubMed | Institute Investigacao Cientifica Bento da Rocha Cabral and New University of Lisbon
Type: Biography | Journal: Endeavour | Year: 2014

In 1756, while he was regent of the Facult de Mdecine in Paris, Charles-Augustin Vandermonde published his Essai sur la Manire de Perfectionner lEspce Humaine. This treatise was situated within the French-led medical movement of meliorism, meant to increase public health by boosting the medical arrangement of marriages from all strata of society. What made Vandermonde different from his colleagues is that he was not just looking for a way to improve the health of society: he was also proposing a series of measures meant to increase the beauty of humankind. And, for the first time in the history of European medicine, he advocated mixed-race couplings as a means to obtain the best results. This latter development is so unexpected in the global setting of the Enlightenment that we could arguably hail Vandermonde as the founding father of what Michel Foucault later called biopolitique.

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