Institute Hematologia e Inmunologia

Cuba

Institute Hematologia e Inmunologia

Cuba
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Alfonso Valdes M.E.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2016

Behcet’s syndrome, also known as Behcet’s disease is a chronic autoinflammatory process of low frequency and unknown etiology. It is a vasculitis affecting arteries and veins of all sizes that causes an alteration of endothelial function and is expressed clinically by organ damage at various levels. It has a higher incidence in countries located in the ancient Silk Road (East Mediterranean, Middle East and East Asia). Its pathogenesis involves genetic, microbial and immunological factors.Symptoms vary from person to person and according to geographical regions, but the most common are oral and genital ulcers, eye inflammation (uveitis, iritis and retinitis), skin lesions and arthritis. In some cases they can present central nervous system, gastrointestinal tract and kidney. As a guide to the diagnosis criteria of International Study Group of Behcet’s disease are used. Treatment includes topical and systemic drugs. The most commonly used are steroids, tumor necrosis factor inhibitors and immunosuppressants. © 2016, Editorial Ciencias Medicas. All rights reserved.


Hernandez Padron C.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2017

Introduction. In the last 25-30 years the treatment of acute promyelocytic leukemia has been proposed by methods of induction of cell differentiation. Method. We compared some of the results of two protocols for the treatment of acute promyelocytic leukemia, LPM-TOA in which the first line drug was arsenic trioxide and LPM-03 in which transretinoic acid was used with Rubidomycin in induction to remission. Results: With LPM-TOA hematologic remission was achieved in 83.3% of patients at 43.22 days on average, the cell differentiation syndrome was present in 6 cases (9.1%), the event free survival at 60 months was 89.26%, as was overall survival, due to the fact that there were no relapses during the study period, whereas with the LPM-03 protocol hematologic remission was achieved in 96% of the patients at 44.35 days; 5 patients (10%) presented the cell differentiation syndrome, the events free survival at 60 months was 75% and the overall survival was 83.3%. In the comparison there was no statistical significance, but not in the disease-free survival at 60 months in which the LPM-TOA was 100% while in the LPM-03 it was 78% (p = 0.001). Conclusions: Arsenic was found to be one more option to manage the disease, both in relapse and in cases of recent diagnosis. With these results, our country shows figures of event-free survival at 5 years of diagnosis and cure comparable to those of the most developed countries worldwide. © 2017, Editorial Ciencias Medicas. All rights reserved.


Garcia W.R.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2016

Sickle cell anaemia (SCD) is a disorder with a high index of morbidity, affecting the quality of life of these patients. Priapism is a common complication of SCD and it is characterized by a prolonged and persistent erection of the penis lasting more than 4 hours without associated sexual stimulation. The 95% of priapism crisis in SCD patients are ischemic type. In this paper we review the new molecular mechanisms implicated in the pathogenesis of ischemic priapism and provide the basis for potential future therapies. © 2016, Editorial Ciencias Medicas. All rights reserved.


Fernandez Delgado N.D.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2016

Myelodysplastic syndromes, now called as myeloid neoplasms, by the World Health Organization, have undergone great changesin recent years. New elements have been identified in pathophysiology with influence indiagnosis, prognosis and therapy of these patients. Many profound discoveries have occurred in molecular biology, cytogenetics and immune phenotyp in go this disease, which lay the foundation for new therapeutic and researchs. This article summarizes themajordevelopments inthe last decade. © 2016, Editorial Ciencias Medicas. All rights reserved.


Hernandez Ramirez P.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2017

Regenerative Medicine is fundamentally based on cell therapy, administration of bioactive factors, tissue engineering and gene therapy. According to their evolutionary state, stem cells can be classified into embryonics and adults. Recently were obtained cells with embryonic characteristics by reprogramming adult cells and have been called induced pluripotent stem cells. Already have been made significant progress in cell therapy using adult stem cells, which have significant advantages over embryonic cells, because its handling is simpler, and can be obtained from the own individual to be treated. The results obtained in Cuba show the benefits that cell therapy can bring to patients with no other therapeutic options and especially under strict scientific control. © 2017, Editorial Ciencias Medicas. All rights reserved.


Macias Abraham C.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2017

The present work, devoted to the 50 years of work of the Institute of Hematology and Immunology, describes the development of the Immunology specialty, its main achievements and scientific results on the fundamentals development lines, such as the introduction of advanced techniques, the immunological study of hemopathies and the diagnosis of primary and secondary immunodeficiencies. Among these, we highlight the introduction of flow cytometry that allowed relevant results in basic immunology, in its application to the study of hemopathies such as sickle cell anemia and the improvement of the immunological diagnosis of acute leukemias in the country. Also, the characterization of stem cells from the bone marrow used in regenerative cell therapy and the immunological study of the patient with chronic renal failure pending renal transplantation in Cuba. © 2017, Editorial Ciencias Medicas. All rights reserved.


Rivero Jimenez R.A.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2017

During the last 50 years, stem cell (SC) allogenic transplant has been an everyday most used form of treatment for the cure of malignant hemopathies and other nonmalignant diseases and genetic disorders, such as sickle cell disease and some primary immunodeficiency. Nevertheless, the lack of adequate donors caused by patients without histocompatible brothers or relatives has made it necessary to look for alternatives in "non-related" donors to guarantee the efficacy and security of transplants. A commonly used source is cord blood (CB); nowadays also known as a source of SC for regenerative medicine. Collection and cryopreservation in CB banks (CBB) have become a reality in many countries due to the importance of these treatments, and to their multiple advantages. Nevertheless, these facilities are subject to national and international regulations, guided by standards and accreditation process. Having a public CBB in Cuba is a need for the development of our National Health System which will allow us to solve the actual donor problem and will allow the international exchange in the struggle for a better public health care. © 2017, Editorial Ciencias Medicas. All rights reserved.


Interferon a (IFN-a), is used together with other antivirals in the treatment of chronic hepatitis C. Autoimmune disorders have been described during its use, particularly thyroid diseases and type 1 diabetes mellitus (DM1), among others. We report the case of a patient with chronic hepatitis C, showing severe symptoms of coma, metabolic ketoacidosis, hyperglycemia and dehydration after 6 months of treatment with IFN-aand ribavirin. The beginning of a secondary DM 1 at the administration of IFN-a was diagnosed. There was no personal or family history of genetic factors predisposing to the development of this disease. The patient was treated in an Emergency Medical Unit (MEU) where medication to control its manifestations was received. Administration of IFN-a was suspended and the ambulatory treatment is maintained, applying insulin in fractional doses adjusted to blood glucose values.


Lavaut Sanchez K.,Institute Hematologia e Inmunologia
Revista Cubana de Hematologia, Inmunologia y Hemoterapia | Year: 2014

Hemophilia is ahereditary bleeding disorderX-linkedthat arises due to mutationsin the genes of factor VIII (hemophilia A) and factor IX (hemophilia B), which causes a decrease or functional deficiency of these proteins in plasma. Their frequencies are 1 in 5 000 males and 1 in 30 000 live births, respectively. It affects males almost exclusively, and female carriers have a 50 % risk of transmitting the disease to their children. So, it is importantin families with history of hemophilia that carriers are identified through genetic counseling, which provides information about the disease, making pedigree, calculation of therisk of recurrence, molecular diagnosis and possibility of prenatal diagnosis inpregnant carriers. It is imperative that genetic counseling constitutes an educational and informative process, never as an imposition.


Coagulogram comprises a set of tests, which explore the participation of all components of hemostasia: vascular endothelium, platelet activity, plasma and fibrinolytic factors. Often, the technical staff finds complex to do these tests, so deepening knowledge, understanding, and interpreting the results of each of these tests should result in strengthening and training of health professionals. This paper describes the main conventional coagulation tests, the beginning and the reference values of each of them, and the possible diseases according to the alteration of the hemostatic system corresponding to the alteration of coagulation, with the aim of providing medical background information for the proper performance and proper interpretation of results.

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