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Introduction: Inflammation is one of the main mechanisms common to all forms of dry eye. Since polyunsaturated acids are known to show biological anti-inflammatory properties, the aim of this study was to evaluate the efficacy of dietary n-6 and n-3 fatty acids in patients suffering from ocular dryness. Patients and methods: One hundred and eighty-one patients diagnosed with bilateral moderate dry eye who were already treated with lachrymal substitutes were randomized in a double-blind international study to receive placebo or Nutrilarm® capsules (combination of omega-3 and omega-6), twice a day for 6 months. In all subjects, dryness feeling, overall subjective comfort, and ocular symptoms (burning, stinging, sandy and/or gritty sensation, light sensitivity, reflex tearing, and ocular fatigue) were evaluated at each visit. Furthermore, fluorescein tests (break-uptime and Oxford scheme) and lissamine green test were performed at each visit. The Schirmer test was performed at inclusion and after 6 months of treatment. Results: After 6 months of supplementation with Nutrilarm®, both the BUT scores and ocular fatigue were significantly improved when compared with placebo (P = 0.036 and P = 0.044, respectively). There was a trend in favor of Nutrilarm® in terms of the efficacy evaluated by the investigator (P = 0.061). Fewer patients experienced a feeling of severe dryness with Nutrilarm® compared with placebo after 6 months of treatment (2.5 and 9.3%, respectively), but the difference was not statistically significant. Conclusion: Oral administration of a double supplementation dietary n-6 and n-3 fatty acids present an additional therapeutic advantage in patients suffering from ocular dryness who were already treated with lachrymal substitutes. © 2011 Publié par Elsevier Masson SAS. Source


Baklouti K.,Service dOphtalmologie | Ayachi M.,Service dOphtalmologie | Chaker N.,Institute Hedi Rais dOphtalmologie | Ahmed N.B.,Service dOphtalmologie | And 5 more authors.
Journal Francais d'Ophtalmologie | Year: 2010

Cavernous hemangioma is the most common primary vascular neoplasm. It typically occurs in middle-aged women, causing a progressive painless proptosis as the principal symptom. It exceptionally compresses the optic nerve. We report the case of a cavernous hemangioma revealed by optic neuropathy in a 33-year-old female. © 2010 Elsevier Masson SAS. All rights reserved. Source


Chebil A.,Institute Hedi Rais dOphtalmologie | Charfi H.,Institute Hedi Rais dOphtalmologie | Largueche L.,Institute Hedi Rais dOphtalmologie | El Matri L.,Institute Hedi Rais dOphtalmologie
Journal Francais d'Ophtalmologie | Year: 2016

Best vitelliform macular dystrophy is the second most frequent hereditary maculopathy, with bilateral involvement and juvenile onset. It is clinically characterized by bilateral deposits of lipofuscin-like autofluorescent material in the subretinal space, with a typical phenotypic manifestation taking the form of a vitelliform macular lesion evolving gradually into more advanced stages. The purpose of our study was to describe fundus autofluorescence patterns and OCT findings in three patients (6 eyes) with several stages of Best vitelliform macular dystrophy. Optical coherence tomography (OCT) has become the first imaging technique to order when confronted with a hereditary maculopathy suggesting Best disease. Fundus autofluorescence combined with OCT allow for better diagnosis and management, which are necessary for any genetic analysis. © 2016 Elsevier Masson SAS Source


Chebil A.,Institute Hedi Rais dOphtalmologie | Kort F.,Institute Hedi Rais dOphtalmologie | Bouraoui R.,Institute Hedi Rais dOphtalmologie | Youssef N.B.,Institute Hedi Rais dOphtalmologie | Matri L.E.,Institute Hedi Rais dOphtalmologie
Journal Francais d'Ophtalmologie | Year: 2010

The complex immunological effects of interferon and ribavirin therapy in hepatitis C virus may also exacerbate or trigger the development of autoimmunity. A rare case of Vogt-Koyanagi-Harada disease associated with ribavirin and interferon-alpha treatment for chronic hepatitis C infection is presented. The potential role of interferon and/or ribavirin therapy is discussed. Physicians should be aware of the association between interferon-alpha 2a and ribavirin use for hepatitis C infection and the development of Harada disease. This severe ophthalmological complication requires close follow-up of hepatitis C virus-infected patients on interferon-alpha treatment. © 2010 Elsevier Masson SAS. All rights reserved. Source


El Matri L.,Institute Hedi Rais dOphtalmologie | Chebil A.,Institute Hedi Rais dOphtalmologie | Bouraoui R.,Institute Hedi Rais dOphtalmologie | Kort F.,Institute Hedi Rais dOphtalmologie | And 2 more authors.
Journal Francais d'Ophtalmologie | Year: 2013

Purpose: To compare the long-term safety and of intravitreal bevacizumab injections (IVB) and verteporferin photodynamic therapy (PDT) in the treatment of choroidal neovascularization (CNV) in high myopia. Methods: Review of retrospectively collected data of 60 eyes of 60 patients with high myopic choroidal neovascularization treated either with standard PDT (PDT group; n = 30) or IVB injections (IVB group; n = 30). The two groups were compared at baseline, 3, 6,12 and 24 months. Results: In the IVB group, mean best corrected visual acuity (BCVA) was significantly improved at 3 to 12 months; however, the significance was lost at 24 months. The PDT group showed an insignificant improvement at 3 and 6 months, then worsened at 12 and 24 months. Mean BCVA was better in the IVB group than the PDT group at 3, 6, 12 and 24 months. The decrease in mean central macular thickness was significantly higher in the IVB group than in the PDT group at 3, 6, 12 and 24 months. At 24 months, chorioretinal atrophy was noted in five eyes (16.6%) treated with IVB and in 22 eyes (73.3%) treated with PDT (P = 2 × 10-5). Conclusion: IVB provides significantly better BCVA than PDT for high myopic CNV over the long-term. © 2012 Publié par Elsevier Masson SAS. Source

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