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Yogev L.,The Institute for the Study of Fertility | Paz G.,The Institute for the Study of Fertility | Kleiman S.E.,The Institute for the Study of Fertility | Shabtai E.,Tel Aviv University | And 5 more authors.
Journal of Andrology | Year: 2012

There has been considerable concern worldwide about possible semen quality deterioration over the last 2 decades. The aim of this study was to evaluate freezability and semen quality of healthy young males during the years 1992-2010. A total of 1211 young (20-32 years old) candidates for sperm bank donation were recruited into the study with no exclusion criteria. They were instructed to observe 2 to 3 days of abstinence from sexual activity, and most of them supplied 2 specimens each. Average values of the various semen parameters, including freezing survival, were calculated for each participant. The change in different semen parameters over years, according to yearly and monthly average temperatures, was evaluated by SAS PROC SURVEYREG analysis. During that period, there were significant increases in motility and vitality percentages, as well as in the percentage of thawed sperm motility. The parameters of volume, concentration, normal morphology, total count, and total motile count showed a significant decrease with years (P, <.01). The significant increase in average yearly temperature (P, <.004) had limited, nonsignificant association with any of the semen variables. However, average monthly temperature contributed significantly to the trend of semen quality parameters (ie, specimen volume, concentration, percentage of normal morphology, and thawed motility). To the best of our knowledge, this is the first demonstration of the occurrence of an improvement in percent thawed motility over the years, and its significance lies in enabling a higher proportion of sperm bank candidates to be suitable for donation. It is suggested that the global warming phenomenon might have only partial contribution to semen variable changes over the years. © American Society of Andrology.

Yogev L.,The Institute for the Study of Fertility | Kleiman S.E.,The Institute for the Study of Fertility | Hauser R.,The Institute for the Study of Fertility | Botchan A.,The Institute for the Study of Fertility | And 3 more authors.
Fertility and Sterility | Year: 2010

Objective: To evaluate the predictive value of a sperm maturation test using the hyaluronan-binding assay (HBA) for freezability potential; and to determine the effect of freezing-thawing on HBA results. Design: Prospective study. Setting: Andrology laboratory at a teaching hospital. Patient(s): Candidates for sperm bank donation (n = 113) and active sperm bank donors (n = 16). Intervention(s): Semen analyses including HBA and sperm freezing-thawing. Main Outcome Measure(s): Percentage of sperm HBA results and other sperm parameters in relation to freezing-thawing results. Result(s): The predictive value of HBA for high freezability value (≥40% postthaw motility) was significant. However, 1- and 4-hour percentage of motility had a higher predictive value for good freezability. A better prognostic value than that of HBA resutlts was also found for sperm concentration and percentage of normal morphology. Freezing-thawing had no significant influence on HBA results. Conclusion(s): To the best of our knowledge this is the first demonstration that sperm maturation, determined by the HBA test, has a low value for predicting freezing-thawing sperm survival. © 2010 American Society for Reproductive Medicine.

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