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Seattle, WA, United States

Institute For Systems Biology | Date: 2014-05-20

The invention is directed to an improved method to manufacture virus for use in vaccine by culturing infected cells that have been modified to overexpress miR-144. The invention is also directed to manipulating the activity or level of miR-144 in subjects in order to modulate the antiviral and immune response systems.

A method of high-density, multiparameter growth analysis founded upon modeling microcolony expansion on solid media is described. The method extracts the key growth parameters (lag time, doubling time, carrying capacity and viability) that together define microcolony growth from seeded cells. The invention relates to a method to determine growth parameters of cells that is scalable, time-resolved and quantitative.

Institute For Systems Biology | Date: 2015-03-06

Point of care methods to detect the probability or status of tuberculosis infection in individuals by determining presence or absence of one or more peptide of SEQ ID NOS:1-22 in a biological fluid of a subject are described. These methods may be assays based on affinity reagents specifically reactive with these peptides.

Institute For Systems Biology | Date: 2013-03-14

Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder.

Integrated Diagnostics and Institute For Systems Biology | Date: 2013-11-05

The present invention relates generally to methods for identifying and using organ-specific proteins and transcripts. The present invention further provides compositions comprising organ-specific proteins and transcripts encoding the same, detection reagents for detecting such proteins and transcripts, and diagnostic panels, kits and arrays for measuring organ-specific proteins/transcripts in blood, biological tissue or other biological fluid.

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