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Ananda Krishna K.,Acharya Nagarjuna University | Sai Krishna K.,Meenakshi Medical College and Research Institute | Berrocal R.,Institute for Scientific Research and Technology Services | Rao K.S.,Institute for Scientific Research and Technology Services | And 2 more authors.
Journal of Natural Science, Biology and Medicine | Year: 2011

Despite the liver being proliferatively quiescent, it maintains balance between cell gain and cell loss, invokes a rapid regenerative response following hepatocyte loss, and restores liver mass. Human liver has immense regenerative capacity. Liver comprises many cell types with specialized functions. Of these cell types, hepatocytes play several key roles, but are most vulnerable to damage. Recent studies suggest that the extrahepatic stem cell pool contributes to liver regeneration. Stem cell therapies have the potential to enhance hepatic regeneration. Both embryonic and induced pluripotent stem cells could be a suitable source to regenerate hepatocytes. In the present review, we discuss the therapeutic potential of stem cells in hepatic repair and focus on the clinical applications of stem cells. Source


Krishna K.,Acharya Nagarjuna University | Krishna K.,Meenakshi Medical College and Research Institute | Berrocal R.,Institute for Scientific Research and Technology Services | Rao K.,Institute for Scientific Research and Technology Services | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2011

Permanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapies lower early mortality rates, prevent additional damage to the heart muscle, and reduce the risk of further heart attacks. However, there is need for treatment to improve the infarcted area by replacing the damaged cells after MI. Thus, the cardiac tissue regeneration with the application of stem cells may be an effective therapeutic option. Recently, interest is more inclined toward myocardial regeneration with the application of stem cells. However, the potential benefits and the ability to improve cardiac function with the stem cell-based therapy need to be further addressed. In this review, we focus on the clinical applications of stem cells in the cardiac repair. Source

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