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Murviel-lès-Montpellier, France

Dujardin J.-P.A.,Mahidol University | Dujardin J.-P.A.,Institute for Research and Development | Kaba D.,Institute Pierre Richet INSP | Henry A.B.,University of Hawaii at Manoa
BMC Research Notes

Background. Landmark based geometric morphometrics (GM) allows the quantitative comparison of organismal shapes. When applied to systematics, it is able to score shape changes which often are undetectable by traditional morphological studies and even by classical morphometric approaches. It has thus become a fast and low cost candidate to identify cryptic species. Due to inherent mathematical properties, shape variables derived from one set of coordinates cannot be compared with shape variables derived from another set. Raw coordinates which produce these shape variables could be used for data exchange, however they contain measurement error. The latter may represent a significant obstacle when the objective is to distinguish very similar species. Results. We show here that a single user derived dataset produces much less classification error than a multiple one. The question then becomes how to circumvent the lack of exchangeability of shape variables while preserving a single user dataset. A solution to this question could lead to the creation of a relatively fast and inexpensive systematic tool adapted for the recognition of cryptic species. Conclusions. To preserve both exchangeability of shape and a single user derived dataset, our suggestion is to create a free access bank of reference images from which one can produce raw coordinates and use them for comparison with external specimens. Thus, we propose an alternative geometric descriptive system that separates 2-D data gathering and analyzes. © 2010 Dujardin et al; licensee BioMed Central Ltd. Source

Siriwardhana C.,Anglia Ruskin University | Siriwardhana C.,Kings College London | Siriwardhana C.,Institute for Research and Development
Conflict and Health

Abstract The month of May 2015 marked the sixth year since the end of conflict in Sri Lanka. The cause of death, destruction and displacement, three decades of conflict has had a major impact on health, especially on mental health of those affected by forced displacement. Post-conflict regions of Sri Lanka has seen improvements in many areas, including resettlement of displaced populations and rebuilding of health-related infrastructure. However, substantial gaps exist around the management of health needs among returnee populations, especially in the area of psychosocial health. Long-term mental health and resilience trajectories of those affected by prolonged displacement and experiencing return migration during post-conflict periods remain important, yet critically understudied areas. © 2015 Siriwardhana. Source

Radovic V.,Institute for Research and Development
Journal of Medical Biochemistry

The serum immunoglobulin free light chain assay measures levels of free κ and λ immunoglobulin light chains. There are three major indications for the free light chain assay in the evaluation and management of multiple myeloma and related plasma cell disorders. In the context of screening, the serum free light chain assay in combination with serum protein electrophoresis and immunofixation yields high sensitivity, and negates the need for 24-hour urine studies for diagnoses other than light chain amyloidosis. Second, the baseline free light chains measurement is of major prognostic value in virtually every plasma cell disorder. Third, the free light chain assay allows for quantitative monitoring of patients with oligosecretory plasma cell disorders, including AL, oligosecretory myeloma, and nearly twothirds of patients who had previously been deemed to have non-secretory myeloma. In AL patients, serial free light chains measurements outperform protein electrophoresis and immunofixation. In oligosecretory myeloma patients, although not formally validated, serial free light chains measurements reduce the need for frequent bone marrow biopsies. In contrast, there are no data to support using free light chain assay in place of 24-hour urine electrophoresis for monitoring or for serial measurements in plasma cell disorders with measurable disease by serum or urine electrophoresis. Source

Siribaddana N.,Institute for Research and Development
Indian journal of medical ethics

Medicine is one of the most sought after professions in the world. However, opportunities for students to realise this dream are few, particularly due to the competitive nature of university entrance examinations. This essay discusses the establishment of private medical schools in Sri Lanka and the expanded opportunities now available for medical students. There are differing perspectives on these developments, among medical professionals as well as the public. We give a background to the controversy followed by opposing views from the first and second author on the regulatory framework in Sri Lanka and providers' commercial agenda. Source

Kulbicki M.,Institute for Research and Development
Marine Ecology Progress Series

Lionfish (Pterois volitans and P. miles) have become a major concern in the western Atlantic and Caribbean since their introduction in the 1980s. Invasive lionfish can reach very high population densities on coral reefs in their invaded range, yet there are few data from their native range in the Indo-Pacific for comparison. We compiled data on the geographical distribution and density of Indo-Pacific lionfishes in their native ranges from published and unpublished under-water visual censuses and field collections. We found that lionfish in their native Indo-Pacific range are unevenly distributed, with higher densities in the Indian Ocean than in the Pacific. Lionfish densities increase significantly with increasing latitude, and are significantly higher in continental areas than around islands. In the Indo-Pacific, lionfishes are found not only on reefs but also on soft bottoms and in nearshore habitats such as seagrass beds and mangroves, and near estuaries. Native lionfish can be found at depths greater than 75 m. Because lionfish can be cryptic and secretive, we estimate that only ∼1/8 of Indo-Pacific lionfishes are detected during general underwater visual censuses. In the Pacific Ocean, the relative abundance of lionfish in the catch of reef-fish larvae is of the same order of magnitude as the relative abundance of adult lionfish within reef fish assemblages. Overall the observed densities of lionfishes in the Indo-Pacific are much lower (max. 26.3 fish ha -1) than the densities reported in their invaded Atlantic range (max. 400 fish ha -1). We found no effects of fishing or pollution on the densities of lionfishes. © 2012 Inter-Research. Source

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