Institute for Parasitology

Leipzig, Germany

Institute for Parasitology

Leipzig, Germany
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Mueller R.S.,Ludwig Maximilians University of Munich | Specht L.,Ludwig Maximilians University of Munich | Helmer M.,Ludwig Maximilians University of Munich | Epe C.,Institute for Parasitology | And 4 more authors.
Veterinary Parasitology | Year: 2011

Canine atopic dermatitis is a common disease and is considered as an animal model of the human disease. Immunomodulation by helminths is reported in several species. The aim of this study was to determine whether nematodes have an immunomodulatory effect on atopic dermatitis in dogs.In the pilot study, 12 atopic dogs were infected with either embryonated eggs of Trichuris vulpis (500 and 2500 eggs in 3 dogs each) or L3 larvae of Uncinaria stenocephala (100, 500 and 2500 eggs in 2 dogs each), respectively, for 3 months. Pruritus was evaluated with visual analogue scales and clinical lesions with the canine atopic dermatitis extent and severity index (CADESI). Skin biopsies were obtained for histopathology at the beginning and end of the study. In the subsequent placebo-controlled, double-blinded, randomised study, 21 dogs received either 2500 embryonated T. vulpis eggs or placebo and were evaluated similarly. In addition, allergen-specific serum IgE concentrations were determined.All dogs in the pilot study improved in their lesion scores, most in their pruritus scores. The cutaneous inflammatory infiltrate did not change significantly. In the subsequent randomised study, there was no significant difference between placebo and Trichuris administration in regard to pruritus or CADESI. IgE concentrations also did not change significantly. Infection with T. vulpis did not significantly change clinical signs of canine atopic dermatitis. © 2011.

Knubben-Schweizer G.,Vetsuisse Faculty Zurich | Ruegg S.,Institute for Parasitology | Torgerson P.,Institute for Parasitology | Rapsch C.,Vetsuisse Faculty Zurich | And 4 more authors.
Veterinary Journal | Year: 2010

Thirty-two dairy cattle farms with fasciolosis as an established herd problem were visited and divided into groups according to the location of the habitats of the intermediate host of Fasciola hepatica. The farms were revisited 4-5. years later and those that had followed the recommended measures were compared to those that had not. Egg shedding and seroprevalence was significantly reduced in cows on farms complying with the control recommendations but was not reduced on farms that had not complied. © 2009 Elsevier Ltd.

Lendner M.,Institute for Parasitology | Daugschies A.,Institute for Parasitology
Parasitology | Year: 2014

Cryptosporidium host cell interaction remains fairly obscure compared with other apicomplexans such as Plasmodium or Toxoplasma. The reason for this is probably the inability of this parasite to complete its life cycle in vitro and the lack of a system to genetically modify Cryptosporidium. However, there is a substantial set of data about the molecules involved in attachment and invasion and about the host cell pathways involved in actin arrangement that are altered by the parasite. Here we summarize the recent advances in research on host cell infection regarding the excystation process, attachment and invasion, survival in the cell, egress and the available data on omics. © Cambridge University Press 2014.

PubMed | Institute for Parasitology
Type: Journal Article | Journal: The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses | Year: 2012

This report describes two cases of isolation of Dacochordodes bacescui Capuse, 1966 from human intestinal infections. In the first case, two adult worms were identified in the vomitus of a man suffering from abdominal pain and nausea. In the second case, a worm was passed in the stool of a woman suffering from abdominal pain and pruritus. Human gastrointestinal infection with this parasite has not previously been reported.

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