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Sienerth A.R.,Institute For Medizinische Strahlenkunde Und Zellforschung Msz | Scheuermann C.,Institute For Medizinische Strahlenkunde Und Zellforschung Msz | Galmiche A.,Institute For Medizinische Strahlenkunde Und Zellforschung Msz | Rapp U.R.,Institute For Medizinische Strahlenkunde Und Zellforschung Msz | Becker M.,Institute For Medizinische Strahlenkunde Und Zellforschung Msz
Immunology and Cell Biology | Year: 2011

Macrophages exert a wide variety of functions, which necessitate a high level of plasticity on the chromatin level. In the work presented here, we analyzed the role of the polycomb group protein Bmi1 during the acute response of bone marrow derived macrophages (BMDM) to lipopolysaccharide (LPS). Unexpectedly, we observed that Bmi1 was rapidly induced at the protein level and transiently phosphorylated upon LPS treatment. The induction of Bmi1 was dependent on MAP-kinase signaling. LPS treatment of BMDM in the absence of Bmi1 resulted in a pronounced increase in expression of the anti-inflammatory cytokine interleukin-10 (IL-10). Our results identify Bmi1 as a repressor of IL-10 expression during macrophage activation. © 2011 Australasian Society for Immunology Inc. All rights reserved. Source

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