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Kemen C.,Abteilung Allgemeine Padiatrie | Baumgarte S.,Institute For Umwelt Und Hygiene | Hoger P.H.,Abteilung Allgemeine Padiatrie
Monatsschrift fur Kinderheilkunde | Year: 2013

Background: Human parechovirus (HPeV) has only recently been described as a causative agent for sepsis-like illness in neonates and young infants. In rare cases, meningoencephalitis and long-term neurological sequelae can occur. HpeV and enterovirus (EV) are important causative agents in neonatal sepsis-like illness. Materials and methods: In this retrospective case-control study, clinical signs and laboratory data of young infants with HPeV (n = 20) and EV (n = 20) infection were compared. Results: HPeV infections in young infants are associated with sepsis-like symptoms such as increased body temperature (100 %), poor feeding (90 %), mottled complexion/reduced acral perfusion (100 %) and irritability (60 %). The general condition of HPeV-infected infants is often worse than that of children with EV infections. White blood cell (WBC), C-reactive protein (CRP) and cerebrospinal (CSF) parameters usually remain normal. Even where HPeV is detected in CSF, the WBC count in CSF is normal. © 2013 Springer-Verlag Berlin Heidelberg.

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