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Zhang X.,Nanjing Medical University | Deng Y.,Nanjing Medical University | Chen F.-L.,Nanjing Medical University | Fang Y.-J.,Nanjing Medical University | And 2 more authors.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology

OBJECTIVE: To establish human B-acute lymphoblastic leukemia NOD/SCID mouse model.METHODS: The unirradiated mice aged 4-5 weeks were injected with Nalm-6 cells via the tail vein. Successful transplantation was assessed by the general state, bone marrow smear and histopathologic examination.RESULTS: After 15 days of injection with Nalm-6 cells, the NOD/SCID mice displayed the morbidily with lethargy, hind limb paralysis, hunched back and lossing weight. The infiltration of leukemia cells could be observed in bone marrow and spleen sections.CONCLUSION: Systemic B lineage acute leukemia animal mode1 has been successfully established in the NOD/SCID mice, which is a useful tool for studying pathogenesis of leukemia and guiding clinical chemotherapy regimens. Source

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