Institute for Experimental Haematology and Transfusion Medicine

Bonn, Germany

Institute for Experimental Haematology and Transfusion Medicine

Bonn, Germany
SEARCH FILTERS
Time filter
Source Type

Muller J.,Institute for Experimental Haematology and Transfusion Medicine | Becher T.,Institute for Experimental Haematology and Transfusion Medicine | Braunstein J.,Institute for Experimental Haematology and Transfusion Medicine | Berdel P.,Clinic for Orthopedic Surgery | And 5 more authors.
Angewandte Chemie - International Edition | Year: 2011

To clot or not to clot: The coagulation system is a multienzymatic network associated with bleeding or thrombosis in patients. A supramolecular oligonucleotide-adapted approach (see picture) makes thrombin, the key enzyme of this network, measurable in vivo. In patients undergoing hip-replacement surgery, thrombin was identified as a valuable biomarker to allow monitoring of the activity level of the coagulation system under clinical conditions. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Rohrbach F.,A-Life Medical | Schafer F.,Goethe University Frankfurt | Fichte M.A.H.,Goethe University Frankfurt | Pfeiffer F.,A-Life Medical | And 4 more authors.
Angewandte Chemie - International Edition | Year: 2013

Lightly unmasked: Large protein subdomains can be masked and photolytically released using aptamers with a suitable photocleavable linker. No structural knowledge of the protein site is needed. Thrombin Exosite-I activity can be efficiently regulated with this approach (see scheme), allowing light-controlled activation of blood clotting. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Loading Institute for Experimental Haematology and Transfusion Medicine collaborators
Loading Institute for Experimental Haematology and Transfusion Medicine collaborators