Institute for Experimental Haematology and Transfusion Medicine

Bonn, Germany

Institute for Experimental Haematology and Transfusion Medicine

Bonn, Germany

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Muller J.,Institute for Experimental Haematology and Transfusion Medicine | Becher T.,Institute for Experimental Haematology and Transfusion Medicine | Braunstein J.,Institute for Experimental Haematology and Transfusion Medicine | Berdel P.,Clinic for Orthopedic Surgery | And 5 more authors.
Angewandte Chemie - International Edition | Year: 2011

To clot or not to clot: The coagulation system is a multienzymatic network associated with bleeding or thrombosis in patients. A supramolecular oligonucleotide-adapted approach (see picture) makes thrombin, the key enzyme of this network, measurable in vivo. In patients undergoing hip-replacement surgery, thrombin was identified as a valuable biomarker to allow monitoring of the activity level of the coagulation system under clinical conditions. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Rohrbach F.,A-Life Medical | Schafer F.,Goethe University Frankfurt | Fichte M.A.H.,Goethe University Frankfurt | Pfeiffer F.,A-Life Medical | And 4 more authors.
Angewandte Chemie - International Edition | Year: 2013

Lightly unmasked: Large protein subdomains can be masked and photolytically released using aptamers with a suitable photocleavable linker. No structural knowledge of the protein site is needed. Thrombin Exosite-I activity can be efficiently regulated with this approach (see scheme), allowing light-controlled activation of blood clotting. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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