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Freckmann G.,Institute for Diabetes Technology GmbH | Pleus S.,Institute for Diabetes Technology GmbH | Haug C.,Institute for Diabetes Technology GmbH | Bitton G.,InsuLine Medical | Nagar R.,InsuLine Medical
Journal of Diabetes Science and Technology | Year: 2012

The absorption profile of rapid-acting insulin analogs delivered subcutaneously is slow compared with physiological insulin. Shorter time to peak and shorter duration of insulin action are important steps toward reducing high postprandial blood glucose concentrations in diabetes therapy and are critical for the development of a closed-loop insulin delivery system. Many attempts have been made to develop more rapidacting insulins. Since the 1950s, different approaches, such as jet injectors and sprinkler needles, which try to increase the absorption areas of injected insulin, have been developed; however, none of them are commonly used in diabetes therapy. Massage and heat increase tissue blood perfusion and, thereby, the absorption of subcutaneously applied insulin. The main focus of this article is a novel device that allows local application of heat to human skin. The device can be connected to a regular insulin pump. This device could demonstrate a significant effect on insulin absorption and postprandial glucose excursions in multiple clinical trials. © Diabetes Technology Society.


Freckmann G.,Institute for Diabetes Technology GmbH | Schmid C.,Institute for Diabetes Technology GmbH | Ruhland K.,Institute for Diabetes Technology GmbH | Baumstark A.,Institute for Diabetes Technology GmbH | Haug C.,Institute for Diabetes Technology GmbH
Journal of Diabetes Science and Technology | Year: 2012

Self-monitoring of blood glucose (SMBG) implicates a number of handling steps with the meter and the lancing device. Numerous user errors can occur during SMBG, and each step adds to the complexity of use. This report compares the required steps to perform SMBG of one fully integrated (the second generation of the Accu-Chek® Mobile), three partly integrated (Accu-Chek Compact Plus, Ascensia® Breeze®2, and Accu-Chek Aviva), and six conventional (Bayer Contour®, Bayer Contour USB, BGStar™, FreeStyle Lite®, OneTouch® Ultra® 2, and OneTouch Verio™Pro) systems. The results show that the fully integrated system reduces the number of steps to perform SMBG. The mean decrease is approximately 70% compared with the other systems. We assume that a reduction of handling steps also reduces the risk of potential user errors and improves the user-friendliness of the system. © Diabetes Technology Society.


PubMed | Institute for Diabetes Technology GmbH
Type: Evaluation Studies | Journal: Journal of diabetes science and technology | Year: 2012

The absorption profile of rapid-acting insulin analogs delivered subcutaneously is slow compared with physiological insulin. Shorter time to peak and shorter duration of insulin action are important steps toward reducing high postprandial blood glucose concentrations in diabetes therapy and are critical for the development of a closed-loop insulin delivery system. Many attempts have been made to develop more rapid-acting insulins. Since the 1950s, different approaches, such as jet injectors and sprinkler needles, which try to increase the absorption areas of injected insulin, have been developed; however, none of them are commonly used in diabetes therapy. Massage and heat increase tissue blood perfusion and, thereby, the absorption of subcutaneously applied insulin. The main focus of this article is a novel device that allows local application of heat to human skin. The device can be connected to a regular insulin pump. This device could demonstrate a significant effect on insulin absorption and postprandial glucose excursions in multiple clinical trials.


PubMed | Institute for Diabetes Technology GmbH
Type: Comparative Study | Journal: Journal of diabetes science and technology | Year: 2012

Self-monitoring of blood glucose (SMBG) implicates a number of handling steps with the meter and the lancing device. Numerous user errors can occur during SMBG, and each step adds to the complexity of use. This report compares the required steps to perform SMBG of one fully integrated (the second generation of the Accu-Chek Mobile), three partly integrated (Accu-Chek Compact Plus, Ascensia Breeze2, and Accu-Chek Aviva), and six conventional (Bayer Contour, Bayer Contour USB, BGStar, FreeStyle Lite, OneTouch Ultra 2, and OneTouch VerioPro) systems. The results show that the fully integrated system reduces the number of steps to perform SMBG. The mean decrease is approximately 70% compared with the other systems. We assume that a reduction of handling steps also reduces the risk of potential user errors and improves the user-friendliness of the system.

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