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Zamani M.,Tarbiat Modares University | Sadeghizadeh M.,Tarbiat Modares University | Behmanesh M.,Tarbiat Modares University | Najafi F.,Institute for Color Science and TechnologyTehran
Phytomedicine | Year: 2015

Abstract bBackground Hepatocellular carcinoma is the fifth most common cancer worldwide, with poor prognosis and resistance to chemotherapy. This gives novel cancer treatment methods an overwhelming significance. Epigenetic therapy of cancer is useful in reversing some of the cancer defects because of reversibility of the epigenetic alterations. Non-protein coding transcripts are the major part of our transcriptome. MEG3 is a tumor suppressor long non-coding RNA being expressed in many normal tissues. Methylation of MEG3 promoter region elicits the decrease in its expression in hepatocellular cancer cells. Bioactive nutrients including curcumin offer great potential in altering DNA methylation status which is catalyzed via DNMT1, DNMT3A and 3B. Purpose Herein, we aimed to study RNA-based epigenetic effects of dendrosomal curcumin (DNC) on hepatocellular cancer (HCC). Study design To this end miRNA-dependent regulation of MEG3 expression under treatment with DNC was studied by evaluating the modulatory involvement of miR-29a for DNMT3A and 3B and miR-185 for DNMT1. Methods We evaluated DNC entrance to HCC cells with the use of fluorescent characteristics of curcumin. Next we performed the MTT assay to evaluate DNC and dendrosome effects on HCC cell viability. The coding and non-coding genes expression analyses were done using quantitative-PCR. Results In result we found that the DNC dependent overexpression of miR-29a and miR-185 (P < 0.01) can down-regulate the expression of DNMT1, 3A and 3B (P < 0.05) and subsequently overexpresses MEG3 (P < 0.05). Conclusion DNC potentially can induce DNA hypomethylation and reexpression of silenced tumor suppressor genes in HCC. These data suggest that DNC could be an effective choice for epigenetic therapy of HCC. © 2015 Elsevier GmbH. Source


Shirkavand Hadavand B.,Institute for Color Science and TechnologyTehran | Ataeefard M.,Iran Institute for Color Science and Technology | Fakharizadeh Bafghi H.,Institute for Color Science and TechnologyTehran
Composites Part B: Engineering | Year: 2015

Powder coating nanocomposite with antibacterial properties is the aim of this study. For this purpose, nano zinc oxide was modified by vinyltrimethoxysilane (VTMS) and Triethoxy(methyl)silane (TEMS). Then various percentages of modified and non-modified nano ZnO (1, 3 and 5%), polyester resin and triglycidyl isocyanurate as a hardener were blended by twin screw extruder. Prepared polymer-matrix composite (PMC) was atomized and coated by electrostatic method on aluminum plates. Finally, samples were cured for 10 min at 200°C. For investigating the thermal stabilities of modified nano particles, thermogravimetric analyses (TGA) were used. Antibacterial properties of coatings were investigated by gram negative bacteria Escherichia coli and gram positive Staphylococcus aureus. The results showed that the coatings demonstrate significant antibacterial activity by increasing amounts of ZnO nanoparticles (5%) when were modified by VTMS. © 2015 Elsevier Ltd. Source


Ramezanzadeh B.,Institute for Color Science and TechnologyTehran | Ghasemi E.,Institute for Color Science and TechnologyTehran | Askari F.,Institute for Color Science and TechnologyTehran | Mahdavian M.,Institute for Color Science and TechnologyTehran
Dyes and Pigments | Year: 2015

Abstract An organic/inorganic hybrid corrosion inhibitive pigment based on zinc acetate/benzotriazole was synthesized. The chemical composition of the pigment was investigated by X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. In addition, the morphology of the pigment was studied by scanning electron microscopy. The pigment solubility in 3.5 wt.% NaCl solution was characterized by UV-Visible, total carbon content and inductively coupled plasma-optical emission spectrometer analyses. The corrosion inhibition properties of the zinc acetate/benzotriazole was compared with conventional zinc phosphate pigment in 3.5 wt.% NaCl solution containing pigments extracts on mild steel samples by polarization test and electrochemical impedance spectroscopy. X-ray photoelectron spectroscopy and scanning electron microscopy characterizations were performed on the steel samples exposed to the extracts to investigate the surface chemistry and morphology of the pigment, respectively. Also, the effects of addition of zinc acetate/benzotriazole and zinc phosphate pigments on the corrosion protection performance of the epoxy coating were studied. Results obtained from X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy analyses confirmed that a complex of Zn-benzotriazole was successfully synthesized. The zinc acetate/benzotriazole pigment showed good solubility in NaCl solution and released inhibitive species including benzotriazole and Zn2+ cations. Zinc acetate/benzotriazole pigment showed good inhibitive properties and reduced dissolution rate of steel through forming Fe-benzotriazole and Zn-benzotriazole complexes, and Zn(OH)2 on the cathodic sites. Also, zinc acetate/benzotriazole enhanced the corrosion protection performance of the epoxy coating and reduced cathodic delamination rate of the coating more than zinc phosphate pigment. © 2015 Elsevier Ltd. Source

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