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Masjkur J.,TU Dresden | Arps-Forker C.,TU Dresden | Poser S.W.,TU Dresden | Nikolakopoulou P.,TU Dresden | And 12 more authors.
Journal of Biological Chemistry | Year: 2014

Background: The transcription factor Hes3 regulates the growth of neural and brain cancer stem cells.Results: Hes3 regulates growth, gene expression, evoked insulin release in cultured insulinoma cells, and sensitivity to streptozotocin in vivo.Conclusion: Hes3 is a novel regulator of cellular functions of importance in diabetes. ©2014 by The American Society for Biochemistry and Molecular Biology, Inc. Source


Wanninger J.,University of Regensburg | Liebisch G.,Institute for Clinical Chemistry and Laboratory Medicine | Schmitz G.,Institute for Clinical Chemistry and Laboratory Medicine | Bauer S.,University of Regensburg | And 5 more authors.
Experimental and Molecular Pathology | Year: 2012

Adiponectin protects from hepatic fat storage but adiponectin deficient mice (APN-/-) fed a standard chow do not develop liver steatosis. This indicates that other pathways might be activated to compensate for adiponectin deficiency. An unbiased and comprehensive screen was performed to identify hepatic alterations of lipid classes in these mice. APN-/- mice had decreased hepatic cholesteryl esters while active SREBP2 and systemic total cholesterol were not altered. Upregulation of cytochromes for bile acid synthesis suggests enhanced biliary cholesterol excretion. Analysis of 37 individual fatty acid species showed reduced stearate whereas total fatty acids were not altered. Total amount of triglycerides and phospholipids were equally abundant. A selective increase of monounsaturated phosphatidylcholine and phosphatidylethanolamine which positively correlate with hepatic and systemic triglycerides with the latter being elevated in APN-/- mice, was identified. Stearoyl-CoA desaturase 1 (SCD1) is involved in the synthesis of monounsaturated fatty acids and despite higher mRNA expression enzyme activity was not enhanced. Glucosylceramide postulated to contribute to liver damage was decreased. This study demonstrates that adiponectin deficiency is associated with hepatic changes in lipid classes in mice fed a standard chow which may protect from liver steatosis. © 2012 Elsevier Inc. All rights reserved. Source

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