Institute for Child and Youth Health Care of Vojvodina

Institute for Child and Youth Health Care of Vojvodina

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Bojanic D.M.,University of Novi Sad | Petrovacki-Balj B.D.,Institute for Child and Youth Health Care of Vojvodina | Jorgovanovic N.D.,University of Novi Sad | Ilic V.R.,University of Novi Sad
Journal of Neuroscience Methods | Year: 2011

Our goal was to simplify the representation and interpretation of surface electromyographic (EMG) activity during gait to develop a clinical method for evaluating gait disabilities in children with cerebral palsy (CP). EMG was recorded from four muscles of a lower extremity. Gait cycles were tracked from one force-sensing resistor signal that was recorded synchronously with EMG. The method is based on the comparison of a patient's dynamic EMG envelope shapes and the normative gait-related patterns (norms). Developed norms were based on EMG data obtained in 10 healthy children. Due to newly introduced techniques for time and amplitude normalization, norms were developed regardless of differences in subject age, gender, basic gait parameters and the EMG measurement process. The proposed gait metric quantifies the similarity between a patient's gait-related patterns and norms by a single global value suitable for gait analysis in general, including a detailed analysis using the 10 partial values. The gait metric was experimentally validated with a control group of healthy children and a group of children with CP with different degrees of motor deficits. Gait metric values obtained in children from the control group are high for all muscles, which means that gait-related patterns are close to norms, whereas in children with CP the higher the degree of motor deficit, the lower the gait metric values. The method could be a very useful clinical tool for the recognition and tracking of motor disorders of the lower extremities in children with CP as well as many other neuromotor pathologies. © 2011 Elsevier B.V.

Djuricic S.M.,Mother And Child Health Institute Of Serbia Dr Vukan Cupic | Grebeldinger S.,Institute for Child and Youth Health Care of Vojvodina | Kafka D.I.,Mother And Child Health Institute Of Serbia Dr Vukan Cupic | Djan I.,Institute for Child and Youth Health Care of Vojvodina | And 2 more authors.
Parasitology International | Year: 2010

Cystic echinococcosis (CE) is a public health problem in countries having such endemic areas. Epidemiological studies of CE, especially pediatric, are rare. The aim of this study was to evaluate epidemiological and clinical characteristics of CE in children in Serbia. Data were obtained retrospectively from the case records of patients under the age of 18 years admitted for surgical treatment of CE at two large pediatric medical institutions in the period 1990-2006. Patients' age, number of cysts and their anatomic location were evaluated in relation to differences by patients' gender and socio-geographic status (urban or rural origin). The study included 149 children with 272 hydatid cysts. The mean age of patients was 10.1 ± 3.8 years. There were no significant differences in the number of patients in relation to gender and urban:rural origin. There were no significant differences in patients' age at the time of surgery or the number of cysts per patient when patients' gender or socio-geographic status was evaluated. The anatomic location of cysts was as follows: liver (N = 165; 60.7%), lungs (N = 82; 30.1%), and other locations (N = 25; 9.2%). Multiple cysts, and combined liver/lung involvement were identified in 34.2% (N = 51), and 6.0% (N = 9) of patients, respectively. Hepatic cysts were significantly more common in girls than in boys. There were no significant differences in anatomic location of cysts between socio-geographic groups. The large number of infected children during a long period of investigation indicates an active transmission of disease and a lack of program for control and prevention of CE in Serbia. © 2010 Elsevier Ireland Ltd. All rights reserved.

Stojanovic V.,Institute for Child and Youth Health Care of Vojvodina | Doronjski A.,University of Novi Sad
Journal of Pediatric Endocrinology and Metabolism | Year: 2013

The case study presents a 3-year-old boy diagnosed with a mild form of 3-methylglutaconic aciduria. During infancy and early childhood, he had lactic acidosis, dilated cardiomyopathy and failure to thrive with growth retardation. A genetic analysis revealed a mutated TMEM70 gene.

Krstic T.,Institute for Child and Youth Health Care of Vojvodina
Medicinski pregled | Year: 2012

Raising a child with cerebral palsy is stressful for the parent because it requires an intensive physical engagement as well as coping with emotional reactions to the child's condition. Parents have different modes of adapting to stress and demands caused by the disorder. The Resiliency Model of Family Stress, Adjustment and Adaptation postulates that the use of certain coping strategies facilitates successful family adaptation to the child's condition. Our study included 60 mothers of two- to seven-year-old children with diagnosed cerebral palsy. The modified Family Crisis-oriented Personal Evaluation Scales, with its five sub-scales, was applied to assess the strategies used by families to cope with stress. The most frequently used strategy is reframing, whereas other strategies were used less frequently. The study has revealed some differences in adoption of certain strategies by mothers from urban and rural areas as well as of those strategies which depend on the severity of the child's condition. The fact that reframing is the most frequently used strategy is encouraging because it helps parents to make their grave situation more acceptable. Institutional support is also often used by mothers of children with severe form of disease because of their need for medical care. Recognition of coping strategies of the parents is important and useful for the development of therapeutic interventions aimed at facilitating family adaptation in families with a child with developmental disabilities.

Pisaric M.,Institute for Child and Youth Health Care of Vojvodina
Medicinski pregled | Year: 2011

Anxiety sensitivity is defined as a belief that anxiety or fear may cause illness, embarrassment, or additional anxiety. The main purpose of this study was to find out if there were differences among adolescents with insulin dependent diabetes mellitus, adolescents with somatoform autonomic dysfunction and their healthy peers in different aspects of psychological functioning and anxiety sensitivity. The sample consisted of 93 subjects, aged 12 to 16. Hamburg Neuroticism and Extraversion Scale, Child Behaviour Checklist and Childhood Anxiety Sensitivity Index were administrated. The adolescents with somatoform autonomic dysfunction had significantly higher scores on neuroticism scale, different Child Behaviour Checklist subscales, and on anxiety sensitivity. Both groups with diagnosed illness had lower scores on extraversion scale compared to healthy peers. This study has shown that the adolescents with somatoform autonomic dysfunction are more prone to fears regarding bodily functioning, and that they are at a higher risk of developing an anxiety disorder.

Meljnikov I.,Institute for Child and Youth Health Care of Vojvodina
Medicinski pregled | Year: 2012

Despite the contemporary diagnostics of intracranial aneurysms their treatment is still a great challenge. The decision when and if to apply a surgical or endovascular treatment of intracranial aneurysms should be made by a team of medical specialists which consists of a cerebrovascular neurosurgeon, neuro-radiologist and neuro-anesthesiologist. We report a case of a patient aged 16 who was admitted because of a sudden intensive headache followed by sickness, vomiting, and loss of consciousness. On admission the patient was conscious but sleepy. Glasgow Coma Scale score was 14 and the World Federation of Neurological Surgeons Scale grade was I. The computed tomography scan showed a massive subarachnoid haemorrhage. The computed tomography angiography and digital subtraction angiography revealed a ruptured saccular aneurysm in the left vertebral artery. An early treatment with the coiling of the lumen of the aneurysm was performed under general anaesthesia. On the tenth day the boy was discharged in good condition and without any neurological deficits. Six months after the intervention the patient was without symptoms and the control digital subtraction angiography showed the complete occlusion of the aneurysm. Intracranial aneurysms in children are more common in males and are predominantly localized in the posterior circulation. In addition, they are frequently of greater size and more complex architecture and they are associated with a lower incidence of clinically manifest vasospasm. According to previous experience, endovascular treatment of intracranial aneurysms in paediatric patients has proven to be a safe and efficient method with a small number of complications.

Matic A.,Institute for Child and Youth Health Care of Vojvodina
Medicinski pregled | Year: 2012

Acute hematogenous osteomyelitis and septic arthritis are pyogenic infections of bone and joint, respectively. At the youngest age, they usually occur at the same time--hence the common name "osteoarthritis". When it comes to neonates, osteoarthritis is an infrequent finding, but it can give a permanent disability and can be even fatal unless early recognized and adequately and promptly treated. An early diagnosis is rather challenging because the signs and symptoms of this disease are subtle and/or nonspecific. The therapy involves a combination of intravenous antimicrobial therapy in high doses and of sufficient duration, with a mandatory decompression of affected joint by needle aspiration or artrhrotomy. The aim of this paper is to present two premature newborns with rare localization of osteoarthritis - the humerus and shoulder joint, as well as to point to the modern diagnostic and therapeutic approach to this disease.

Stojanovic V.,Institute for Child and Youth Health Care of Vojvodina | Vuckovic N.,Center for Pathology and Histology | Spasojevic S.,Institute for Child and Youth Health Care of Vojvodina | Barisic N.,Institute for Child and Youth Health Care of Vojvodina | And 2 more authors.
Pediatric Nephrology | Year: 2012

The aim of this study was to determine the effects of erythropoietin (EPO), moderate hypothermia, and a combination thereof on the kidneys of newborn rats damaged during perinatal asphyxia. An animal model of perinatal asphyxia (Wistar rats) was used in which after birth, newborn rats were divided into four groups of 15 animals each: G1, rats exposed only to asphyxia; G2, rats exposed to asphyxia and hypothermia (rectal temperature 32°C) and which received EPO (darbepoetin alpha) intraperitoneally; G3, rats exposed to asphyxia and hypothermia; G4, rats exposed to asphyxia and which received EPO. The rats were sacrificed on the 7th day of life and histopathological evaluation of kidneys was performed. Damage to the proximal tubules was significantly higher in group G1 rats than in groups G2, G3, and G4 rats (p∈<∈0.01). Damage to the distal tubules was found only in group G1 rats. Histological changes in the proximal tubules were more prominent than in the distal tubules (p∈<∈0.01). The immature glomeruli zone was less expressed in group G4 rats than in groups G1, G2, and G3 rats (p∈<∈0.01). Based on these results, we conclude that EPO and hypothermia, as well as the combination thereof, have a protective effect on rats' kidneys damaged during perinatal asphyxia. © 2011 IPNA.

Zivkovic D.,Institute for Child and Youth Health Care of Vojvodina | Zivkovic D.,University of Novi Sad | Fratric I.,Institute for Child and Youth Health Care of Vojvodina
BioMed Research International | Year: 2014

Male reproductive function in the general population raises an increased attention due to reports indicating declining sperm counts, increased occurrence of testicular cancer, cryptorchidism, and hypospadias. It is also hypothesized that prolonged exposure of the developing male, during both fetal and postnatal life, to exogenous estrogens could reduce Sertoli cell number and thus reduce sperm output (and sperm counts) in adult life. Fact is that infertility, which is defined as the inability to conceive after 1 year of unprotected intercourse, has a global prevalence of 9%. A male contributory factor is involved in approximately half of these cases, but most of the causes of reduced semen quality and other disturbances of male reproductive function are unknown. In the most affected men (azoospermic men) 15-20% had a prior history of cryptorchidism. The association between the cryptorchidism and infertility is one of the most studied potential causes of infertility. There are numerous studies that accentuate the importance of minipuberty for future fertility. Is it possible that a normal minipuberty ensures normal fertility despite malpositioned testes? And to move away from cryptorchidism, could impaired minipuberty be responsible for fertility problems in men who were born with both testes in their scrotal sacs? © 2014 D. Živković and I. Fratrić.

Stojanovic V.,Institute for Child and Youth Health Care of Vojvodina | Vukavic T.,Institute for Child and Youth Health Care of Vojvodina
Indian Journal of Pediatrics | Year: 2011

Objective: To examine the effect of hyperbilirubinemia on lower urinary tract function. Methods: The study was conducted on 29 patients with suspected Gilbert's syndrome (GS), and who were subjected to fasting test for diagnostic purpose. The uroflowmetric test was performed after 24 h of fasting and after 24 h of hypercaloric intake. Results: After a 24 h fasting period, when bilirubin in the serum was at its highest concentration, 31% of patients had abnormal uroflowmetric patterns. Patients with abnormal uroflowmetric patterns had higher conjugated bilirubin after 24 h fasting period than patients with normal pattern (p=0.012). After a 24 h of hypercaloric intake, all 29 patients had a normal (bell-shaped) uroflowmetric pattern. Conclusions: The results imply that hyperbilirubinemia might be a predisposing factor for intermittent lower urinary tract dysfunction in children. © 2010 Dr. K C Chaudhuri Foundation.

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