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Pichler G.P.,Institute for Cardiovascular and Metabolic Medicine | Amouzadeh-Ghadikolai O.,KH d. Barmherzigen Bruder Graz Eggenberg | Leis A.,Joanneum Research | Skrabal F.,Institute for Cardiovascular and Metabolic Medicine
Medical Engineering and Physics | Year: 2013

Aim of the study was to assess the accuracy and precision of a BIS device and the relative contribution of BIS beyond the anthropometric parameters. The output of the Impedimed device (SFB7) and the relative contribution of height, weight, age, sex and resistance values at zero and infinite frequency (Rzero and Rinf respectively) to the prediction of total body water (TBWd, deuterium space), of extracellular fluid (ECFbr, sodium bromide space) and of fat mass (FMDXA) were assessed in 116 subjects (32 healthy subjects and 84 patients with disorders of body composition). Using a repeated randomization procedure, new equations for TBW, ECF and FM were derived. The SFB7 gave measures of determination similar to those obtained with equations that included only anthropometric data. The SFB7, but not the newly derived regression equations, underestimated TBW and ECF by 3.82±3.37 (mean±SD) and by 0.93±2.62l and overestimated FM by 6.55±3.86kg. Nine of 16 patients with ECF overload as detected by ECFbr were also detected by BIS. BIS measurements contribute marginally but not significantly beyond anthropometric data to the prediction of TBW, ECF and FM, either in healthy subjects or in patients with disturbed body composition. © 2012 IPEM. Source


Skrabal F.,Institute for Cardiovascular and Metabolic Medicine | Pichler G.P.,Institute for Cardiovascular and Metabolic Medicine | Gratze G.,Medical University of Graz | Holler A.,Medical University of Graz
Medical Engineering and Physics | Year: 2014

Objectives: In primary care the diagnosis of CHF and ECF accumulation is no triviality. We aimed to predict plasma BNP, CHF and ECF accumulation with segmental impedance spectroscopy while using and extending the electrodes of the conventional electrocardiography. Methods: Three combined multiple electrodes were added to the 15 lead ECG for segmental impedance spectroscopy and for measuring the maximal rate of segmental fluid volume change with heart action at the thorax and the legs. The obtained signals were analyzed by partial correlation analyses in comparison with plasma BNP, CHF classes, ejection fraction by echocardiography and cardiac index by double gas re-breathing. 119 subjects (34 healthy volunteers, 50 patients with CHF, NYHA classes II to IV and 35 patients without CHF) were investigated. Results: The maximal rate of volume change with heart action at the thorax and at the legs, as well as the ECF/ICF ratio at the legs contribute equally and independently to the prediction of BNP and heart failure in an unknown test sample of 49 patients (multiple r= 0.88, p < 0.001). The ROC-curve for the predicted plasma BNP > 400. pg/ml gave an AUC = 0.93. The absence or the presence of heart failure could be predicted correctly by a binomial logistic regression in 92.9 and 87.5% of cases, respectively. Conclusion: The methodology, which is based on inverse coupling of BNP release and of maximal blood acceleration and on sensitive detection of ECF overload, could enable the diagnosis of CHF with useful sensitivity and specificity while writing a routine-ECG. © 2014 IPEM. Source

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