Eggenstein-Leopoldshafen, Germany
Eggenstein-Leopoldshafen, Germany

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Wuest K.N.R.,Karlsruhe Institute of Technology | Wuest K.N.R.,Institute For Biologische Grenzflachen Ibg | Wuest K.N.R.,University of New South Wales | Trouillet V.,Karlsruhe Institute of Technology | And 5 more authors.
Macromolecules | Year: 2016

A light-triggered strategy to functionalize nanodiamonds (NDs) with well-defined functional polymers is presented. The employed grafting approach is based on o-methylbenzaldehydes, which upon UV irradiation form o-quinodimethanes that undergo Diels-Alder reactions with dienophiles. A series of well-defined maleimide end-group functional polymers, i.e., poly(styrene) (Mn = 5800 g mol-1; D = 1.2), poly(N-isopropylacrylamide) (Mn = 5800 g mol-1, D = 1.2), and poly(2-(2′,3′,4′,6′-tetra-O-acetyl-α-d-mannosyloxy)ethyl methacrylate) (Mn = 24 300, 39 000, and 58 800 g mol-1, D ≤ 1.3), were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization of protected maleimide functional RAFT agents. After deprotection of the furan-protected maleimide end groups, the polymers were photografted to o-methylbenzaldehyde functional NDs and characterized in detail via infrared (IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The grafting density decreases with increasing polymer chain length (6.9-3.8 μmol g-1). Moreover, the binding of the glycopolymer functional NDs to the lectin Concanavalin A was demonstrated with a turbidity assay. © 2016 American Chemical Society.

Pauloehrl T.,Karlsruhe Institute of Technology | Welle A.,Institute For Biologische Grenzflachen Ibg | Bruns M.,Karlsruhe Institute of Technology | Linkert K.,Humboldt University of Berlin | And 7 more authors.
Angewandte Chemie - International Edition | Year: 2013

A phencyclone derivative is used to achieve light-controlled immobilization of peptides possessing only natural amino acids. The photoactive precursor (blue in picture) is formed in a Diels-Alder reaction and can undergo light-triggered ring-opening reactions with amines. Successful surface patterning with a genuine c(RGDfK) peptide (green) is evidenced by imaging time-of-flight secondary-ion mass spectrometry (ToF-SIMS). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Preuss C.M.,Karlsruhe Institute of Technology | Preuss C.M.,Institute For Biologische Grenzflachen Ibg | Tischer T.,Karlsruhe Institute of Technology | Tischer T.,Institute For Biologische Grenzflachen Ibg | And 9 more authors.
Journal of Materials Chemistry B | Year: 2014

An avenue for the development of spatially resolved functional interfaces is presented. By introducing a novel, photo-reactive molecule-carrying a DOPA functionality and a photo-reactive group-we merge the ability of mussels to adhere to any surface with the spatial and temporal control of photo-click reactions, opening a plethora of applications in the biomedical and materials fields. © 2014 The Royal Society of Chemistry.

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