Schmidt S.,Institute For Biochemie Und Molekularbiologie Ii |
Essmann F.,University of Tübingen |
Cirstea I.C.,Institute For Biochemie Und Molekularbiologie Ii |
Kuck F.,Institute For Biochemie Und Molekularbiologie Ii |
And 10 more authors.
Cell Cycle | Year: 2010
Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular senescence. We have compiled recent evidence that inhibition or depletion of various mitotic proteins which take over key roles in centrosome and kinetochore integrity and mitotic checkpoint function is sufficient to activate a p53-p21WAF driven premature senescence phenotype. These findings have direct implications for proliferative tissue homeostasis as well as for cellular and organismal aging. © 2010 Landes Bioscience.