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Silva I.D.,Institute Ensino E Pesquisa Da Santa Casa Of Belo Horizonte Iep Scbh | Muniz Y.C.N.,Federal University of Santa Catarina | Sousa M.C.P.S.,Institute Ensino E Pesquisa Da Santa Casa Of Belo Horizonte Iep Scbh | Silva K.R.,Institute Ensino E Pesquisa Da Santa Casa Of Belo Horizonte Iep Scbh | And 3 more authors.
Human Immunology | Year: 2013

Besides HPV infection, the progression to cervical cancer also depends on the host immune response. HLA-G molecules are involved in the inhibition of cell-mediated immune responses and may permit the development of an infection in the female cervical tract. The aim of this study was to explore the possible influence of the two HLA-G polymorphisms located on the 3'UTR on the susceptibility to cervical cancer and risk factors in Brazilian patients. Polymorphism analysis (14bp In/Del and +3142C/G) was performed by PCR. A total of 105 cervical samples were tested, 50 without lesions and 55 with lesions; 22 with high grade (HSIL) and 33 with invasive cancer (ICC). The polymorphisms *Del/Del was associated with a decreased risk of developing ICC in smokers and *In and *In/In were associated with an increased risk of HSIL and a higher risk of ICC in smokers. The genotype *In/Del was associated with the increased risk of HSIL only among women with a family history of cancer. The haplotypes *In/G and *Del/G were associated with increased and decreased risk of HSIL and cervical cancer, respectively. In conclusion, the 3'UTR of HLA-G is associated with an increased risk of developing cervical cancer, especially in smokers. © 2012 American Society for Histocompatibility and Immunogenetics.


De Figueiredoa S.M.,Institute Ensino E Pesquisa Da Santa Casa Of Belo Horizonte Iep Scbh | De Figueiredoa S.M.,Federal University of Ouro Preto | Nogueira-Machado J.A.,Institute Ensino E Pesquisa Da Santa Casa Of Belo Horizonte Iep Scbh | De Almeida B.M.,Nectar Pharmaceuticals | And 5 more authors.
Recent Patents on Endocrine, Metabolic and Immune Drug Discovery | Year: 2014

Propolis is a resinous material collected by honeybees from numerous plants and serves as a defense against intruders. Because of its relevant curative properties, it is now gaining popularity in health foods and in cosmetic products. Understanding the underlying molecular mechanisms of phytochemicals has become a good strategy in bioprospection for new anti-inflammatory compounds. The biological activity of propolis derives from its high levels of phenolic acids, while flavonoids are thought to account for the activity of propolis extracts. The comprehension of the relationship between propolis and the immune system has progressed in the last years, recent articles have provided important contributions to this investigation field. Studies have shown that propolis suppressed the "IL-6-induced phosphorylation of signal transducer and STAT3", an essential cytokine-activated transcription factor in Th17 development. Therefore, action mechanisms of "propolis on Th17 differentiation could be instrumental in controlling disturbed cytokine networks in inflammation, autoimmune diseases, and infections." The use of propolis has been proposed in some patents as: WO201363714; CN102885854, WO2013142936, US20130266521, and US20130129808, which are related to the treatment of dental diseases; adjuvant in anti-cancer treatment; in cosmetic products; as an anti-inflammatory agent and natural antibiotic. Although there are many publications regarding the propolis efficacy, its applicability to human health and mechanisms of action are not completely understood, creating opportunities for new studies. © 2014 Bentham Science Publishers.

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