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Garcia D.P.C.,Institute Ensino e Pesquisa da Santa Casa | Santos Neto C.,Hospital Universitario Sao Jose | Hubner P.N.V.,Hospital Felicio Rocho | Furtado T.A.,Hospital Felicio Rocho | And 3 more authors.
Acta Cirurgica Brasileira | Year: 2016

PURPOSE: To develop an experimental model for incisional hernias and to compare morphological and functional aspects of hernia repairs by suture, polypropylene mesh and collagen mesh. METHODS: A defect measuring 7cm x 2cm was created in the anterior abdominal of 28 New Zealand male rabbits, divided into four groups (n = 7): (1) control, (2) suture of the anterior sheath of the rectus abdominal muscle, (3) setting of polypropylene mesh, and (4) setting of collagen mesh. On the 90th postoperative day, the animals were examined to verify the presence of incisional hernia. Samples of abdominal wall and scar were collected for histological study. RESULTS: Incisional hernia was identified in 85.7% of the control group, 57.1% of the suture group, 42.9% of the collagen mesh group, and none in the polypropylene mesh group (p = 0.015). Mesh exposure could be identified in 71.4% of the animals in group 3 and in no animal in group 4 (p = 0.021). The polypropylene mesh is effective in the treatment of abdominal wall defects, causing an intense inflammatory reaction. CONCLUSION: The collagen mesh is biocompatible, producing a minimal inflammatory reaction, but fails in the treatment of abdominal wall defects. © 2016,Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All Rights reserved. Source


Diniz D.M.,Institute Ensino e Pesquisa da Santa Casa | De Souza A.H.,Lutheran University of Brazil | Pereira E.M.R.,Federal University of Minas Gerais | Da Silva J.F.,Institute Ensino e Pesquisa da Santa Casa | And 8 more authors.
Pharmacology Biochemistry and Behavior | Year: 2014

The effects of intrathecal administration of the toxins Phα1β and ω-conotoxin MVIIA were investigated in visceral nociception induced by an intraperitoneal injection of acetic acid and an intracolonic application of capsaicin. The pretreatments for 2 h with the toxins reduced the number of writhes or nociceptive behaviors compared with the control mice. Phα1β administration resulted in an Imax of 84 ± 6 and an ID50 of 12 (5-27), and ω-conotoxin MVIIA resulted in an Imax of 82 ± 9 and an ID50 of 11 (4-35) in the contortions induced by the intraperitoneal injection of acetic acid. The administration of Phα1β resulted in an Imax of 64 ± 4 and an ID50 of 18 (9-38), and ω-conotoxin MVIIA resulted in an Imax of 71 ± 9 and an ID50 of 9 (1-83) in the contortions induced by intracolonic capsaicin administration. Phα1β (100/site) or ω-conotoxin MVIIA (30 pmol/site) pretreatments caused a reduction in CSF glutamate release in mice intraperitoneally injected with acetic acid or treated with intracolonic capsaicin. The toxin pretreatments reduced the ROS levels induced by intraperitoneal acetic acid injection. Phα1β, but not ω-conotoxin MVIIA, reduced significantly the ROS levels induced by intracolonic capsaicin administration. Source


De Souza A.H.,Lutheran University of Brazil | Da Costa Lopes A.M.,Institute Ensino e Pesquisa da Santa Casa | Castro Jr. C.J.,Institute Ensino e Pesquisa da Santa Casa | Pereira E.M.R.,Federal University of Minas Gerais | And 6 more authors.
Toxicon | Year: 2014

This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM). Repeated administration of reserpine (0.25 mg/kg sc) once daily for three consecutive days significantly decreased thermal hyperalgesia, mechanical allodynia, and dopamine and serotonin content in the brain on the 4th day. Phα1β and pregabalin treatment completely reverted the mechanical allodynia and thermal hyperalgesia induced by reserpine treatment on the 4th day, but diclofenac was ineffective. Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals. Phα1β, but not pregabalin, reduced the immobility time (56%), suggesting that Phα1β may control persistent pathological pain in FM. © 2014 Elsevier B.V. Source

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