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São Paulo, Brazil

Coelho F.M.S.,University of Toronto | Coelho F.M.S.,Institute Ensino e Pesquisa | Georgsson H.,University of Toronto | Narayansingh M.,University of Alberta | And 2 more authors.
Journal of Clinical Sleep Medicine | Year: 2010

Study Objectives: The association between obstructive sleep apnea and stroke is well established. Less is known about the relationship between stroke and periodic limb movements of sleep (PLMS). This study sought to assess the frequency of PLMS in patients with a history of stroke. Methods: We reviewed the medical and polysomnographic records of 40 patients with a history of stroke and 40 control patients matched for age, sex, and risk factors. Results: 19 patients with a history of stroke (47.5%) and 5 control patients (12.5%) had a PLMS index > 5/h (p < 0.001). The average PLMS index was also lower in control patients than patients with stroke (1.9±0.7 and 11.7±3.4; p = 0.006). Conclusions: Our patients with a history of stroke had a greater prevalence and severity of PLMS than control patients. These limb movements may have implications for secondary stroke prevention as well as stroke recovery. Source


Sandoval Jr. L.,Institute Ensino e Pesquisa
Advances in Complex Systems | Year: 2012

The correlation matrix of stocks returns is used in order to create maps of the São Paulo Stock Exchange (BM&F-Bovespa), Brazil's main stock exchange. The data refer to the year 2010, and the correlations between stock returns lead to the construction of a minimum spanning tree and of asset graphs with a variety of threshold values. The results are analyzed using techniques of network theory. Also, using data from 2007 to 2010, a study is made on the dynamics of the network formed by stocks from that same stock exchange. © 2012 World Scientific Publishing Company. Source


Sandoval Jr. L.,Institute Ensino e Pesquisa
Physica A: Statistical Mechanics and its Applications | Year: 2012

This work employs various techniques in order to filter random noise from the information provided by minimum spanning trees obtained from the correlation matrices of international stock market indices prior to and during times of crisis. The first technique establishes a threshold above which connections are considered affected by noise, based on the study of random networks with the same probability density distribution of the original data. The second technique is to judge the strength of a connection by its survival rate, which is the amount of time a connection between two stock market indices endures. The idea is that true connections will survive for longer periods of time, and that random connections will not. That information is then combined with the information obtained from the first technique in order to create a smaller network, in which most of the connections are either strong or enduring in time. © 2011 Elsevier B.V. All rights reserved. Source


Vidal-Dourado M.,Federal University of Sao Paulo | Conforto A.B.,University of Sao Paulo | Conforto A.B.,Institute Ensino e Pesquisa | Caboclo L.O.S.F.,Federal University of Sao Paulo | And 3 more authors.
Neuroscientist | Year: 2014

The idea that magnetic fields could be used therapeutically arose 2000 years ago. These therapeutic possibilities were expanded after the discovery of electromagnetic induction by the Englishman Michael Faraday and the American Joseph Henry. In 1896, Arsène d'Arsonval reported his experience with noninvasive brain magnetic stimulation to the scientific French community. In the second half of the 20th century, changing magnetic fields emerged as a noninvasive tool to study the nervous system and to modulate neural function. In 1985, Barker, Jalinous, and Freeston presented transcranial magnetic stimulation, a relatively focal and painless technique. Transcranial magnetic stimulation has been proposed as a clinical neurophysiology tool and as a potential adjuvant treatment for psychiatric and neurologic conditions. This article aims to contextualize the progress of use of magnetic fields in the history of neuroscience and medical sciences, until 1985. © 2013 The Author(s). Source


Trindade D.,Federal University of Minas Gerais | Orsine L.A.,Federal University of Minas Gerais | Barbosa-Silva A.,University of Luxembourg | Donnard E.R.,Institute Ensino e Pesquisa | Ortega J.M.,Federal University of Minas Gerais
Methods | Year: 2015

Genomic information is being underlined in the format of biological pathways. Building these biological pathways is an ongoing demand and benefits from methods for extracting information from biomedical literature with the aid of text-mining tools. Here we hopefully guide you in the attempt of building a customized pathway or chart representation of a system. Our manual is based on a group of software designed to look at biointeractions in a set of abstracts retrieved from PubMed. However, they aim to support the work of someone with biological background, who does not need to be an expert on the subject and will play the role of manual curator while designing the representation of the system, the pathway. We therefore illustrate with two challenging case studies: hair and breast development. They were chosen for focusing on recent acquisitions of human evolution. We produced sub-pathways for each study, representing different phases of development. Differently from most charts present in current databases, we present detailed descriptions, which will additionally guide PESCADOR users along the process. The implementation as a web interface makes PESCADOR a unique tool for guiding the user along the biointeractions, which will constitute a novel pathway. © 2014 Elsevier Inc. Source

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