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Farina P.V.R.,Div de Ingenieria Biomedica | Turiel J.P.,Div de Ingenieria Biomedica | Pagan-Buzo F.J.,Hospital Virgen Of La Salud | Sarmiento E.G.,Institute Endocrinologia y Nutricion | And 2 more authors.
Computing in Cardiology | Year: 2010

It has already been shown that many of the complications that we associate with diabetes appear in the patient in early stages of diabetes, or even before the disease is developed. The aim of this paper, then, is to check whether Qtc (corrected with bazett's formula) is altered in these prior stages of diabetes (insulin resistance and/or altered glucose according to the American Diabetes Association) when compared to healthy subjects. In this paper we revisit the wavelet transform method for delineating the ECG. We use the extreme on the second (third) derivative which first appear ahead of the inflexion point of a T-wave. The algorithm detects Q waves with the first scale of a quadratic spline WT while detects the end of the T-wave by using the first derivative on the fourth (fifth) scale. Results were obtained in our database (data acquired in the Hospital Clínico Universitario de Valladolid). This database includes 34 healthy subjects 32 pre-diabetic and 33 type 2 diabetic patients. We found QTc to be 0.3767s+/-0.03s for healthy subjects and 0.3901s+-0.03s in the case of prediabetic patients. Even though there is a sligth enlargement of the QT interval in prediabetic respect to healthy subjects, the difference in the values doesn't seem to be of statistical significance.

De Luis D.A.,Institute Endocrinologia y Nutricion | Gonzalez Sagrado M.,Institute Endocrinologia y Nutricion | Aller R.,Institute Endocrinologia y Nutricion | Izaola O.,Institute Endocrinologia y Nutricion | And 2 more authors.
Endocrinologia y Nutricion | Year: 2010

Introduction: The 385 C/A polymorphism of fatty acid amide hydrolase (FAAH) has recently been demonstrated to be associated with overweight and obesity. The aim of our study was to investigate the association between missense polymorphism (cDNA 385 C->A) of the FAAH gene and anthropometric parameters, cardiovascular risk factors and adipocytokines in morbidly obese patients. Material and methods: A sample of 66 morbidly obese patients was analyzed. In all patients, weight, blood pressure, fasting glycemia, lipoprotein(a), C-reactive protein, insulin, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglyceride and adipocytokine levels, as well as the genotype of the C358A polymorphism of FAAH, were determined. Results: The mean age was 48.0(16.1) years and the mean body mass index was 44.4 (4.1). There were 17 males (25.8%) and 49 females (74.2%). Forty-five patients (8 males/37 females) (68.2%) were G358G (wild genotype) and 21 patients (4 males/17 females) were G358A (31.8%) (mutant group). Biochemical, anthropometrical and adipocytokine levels showed no statistically significant differences between the two genotypes. Conclusion: In patients with morbid obesity, the C358A polymorphism of FAAH was not associated with anthropometric parameters, biochemical markers or adipocytokine levels. © 2009 SEEN.

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