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Tarragona S.,Finanzas Publicas Provinciales y Municipales | Monteverde M.,National University of Cordoba | Caporale J.,Institute Efectividad Clinica y Sanitaria IECS | Pereiro A.C.,Responsable del area medica | Palacios J.M.,Institute Investigaciones Of Enfermedades Tropicales Iiet
Salud Colectiva | Year: 2012

The present study estimates the economic burden associated with the cases of dengue recorded during the 2009 Argentine epidemic. Among the costs considered are the medical costs necessary for the treatment of those affected and the opportunity costs for those who stopped working or studying because of the disease. In order to assess the costs of the disease, at the end of 2009 an ad-hoc survey was carried out in 201 households where people that had contracted dengue during the 2009 epidemic lived. The results allow us to estimate between 26 to 40 million Argentine pesos (6 to 9 million US dollars) as the total cost of the recorded cases. The regions in the north of Argentina bore the highest economic burden of the disease (more than 90% of the total burden). For all regions, the social cost of one dengue case accounts for more than 40% of the average monthly net individual income.


Belizan J.M.,Institute Efectividad Clinica y Sanitaria IECS | Hofmeyr J.,University of Witwatersrand | Buekens P.,Tulane University | Salaria N.,Biomedical Central
Reproductive Health | Year: 2013

Premature birth is the world's leading cause of neonatal mortality with worldwide estimates indicating 11.1% of all live births were preterm in 2010. Preterm birth rates are increasing in most countries with continual differences in survival rates amongst rich and poor countries. Preterm birth is currently an important unresolved global issue with research efforts focusing on uterine quiescence and activation, the 'omics' approaches and implementation science in order to reduce the incidence and increase survival rates of preterm babies. The journal Reproductive Health has published a supplement entitled Born Too Soon which addresses factors in the preconception and pregnancy period which may increase the risk of preterm birth and also outlines potential interventions which may reduce preterm birth rates and improve survival of preterm babies by as much as 84% annually. This is critical in order to achieve the Millennium Development Goal (MDG 4) for child survival by 2015 and beyond. © 2013 Belizán et al.; licensee BioMed Central Ltd.


Poggio R.,Fundacion FLENI | Poggio R.,Institute Efectividad Clinica y Sanitaria IECS | Arazi H.C.,Fundacion FLENI | Giorgi M.,Fundacion FLENI | And 3 more authors.
American Heart Journal | Year: 2010

Background: Peak Vo2 has traditionally been used for prognostic evaluation in systolic heart failure. However, in the past years, VE/Vco 2 slope has been shown to be similar or even superior in many studies. We performed a systematic review and a meta-analysis of diagnostic studies of VE/Vco2 slope to assess its ability to predict cardiovascular events in systolic heart failure. Methods: We searched the published literature in PubMed and ISI Web of Science for VE/Vco2 slope in heart failure, and performed a systematic review and a meta-analysis of diagnostic studies in articles fulfilling previously established selection criteria. End points were serious cardiovascular events defined as death or the combined end point of death, ventricular assist device implantation, or heart transplant. A sub-analysis was also performed with those articles providing enough data to compare VE/Vco2 slope prognostic ability to that of peak Vo2. Results: Four hundred ninety-one articles that are potentially relevant were identified, and 12 studies were selected based on our predefined criteria. No heterogeneity or evidence of publication bias was found. The 12 studies included a total of 2,628 patients with a mean follow-up of 31 months (95% CI 16-46 months). The combined event rate at 1 year was 11.2% (95% CI 7.8%-14.6%). Diagnostic odds ratio and area under the curve for serious cardiovascular events were 5.02 (95% CI 4.06-6.21) and 0.75 (95% CI 0.72-0.78), respectively. Six studies provided sufficient data for VE/Vco2 slope and peak Vo2 comparison. Both variables showed similar performance, although VE/Vco2 did present a trend to superiority. Conclusions: In this meta-analysis, VE/Vco2 slope represents a reasonable ability to predict serious cardiovascular events in systolic heart failure, and is at least as effective as peak Vo2. © 2010 Mosby, Inc.


Santesso N.,McMaster University | Rader T.,University of Ottawa | Nilsen E.S.,Norwegian branch of the Nordic Cochrane Center | Glenton C.,Norwegian branch of the Nordic Cochrane Center | And 7 more authors.
Journal of Clinical Epidemiology | Year: 2015

Objectives To evaluate a new format of a summary, which presents research from synthesized evidence to patients and the public. Study Design and Setting We conducted a randomized controlled trial in 143 members of the public from five countries (Canada, Norway, Spain, Argentina, and Italy). Participants received either a new summary format (a plain language summary [PLS]) or the current format used in Cochrane systematic reviews. The new PLS presents information about the condition and intervention, a narrative summary of results, and a table of results with absolute numbers for effects of the intervention and quality of the evidence using Grading of Recommendations Assessment, Development, and Evaluation. Results With the new PLS, more participants understood the benefits and harms and quality of evidence (53% vs. 18%, P < 0.001); more answered each of the five questions correctly (P≤ 0.001 for four questions); and they answered more questions correctly, median 3 (interquartile range [IQR]: 1-4) vs. 1 (IQR: 0-1), P < 0.001). Better understanding was independent of education level. More participants found information in the new PLS reliable, easy to find, easy to understand, and presented in a way that helped make decisions. Overall, participants preferred the new PLS. Conclusion This new PLS format for patients and the public is a promising tool to translate evidence from synthesized research. ©2015 The Authors.


Glujovsky D.,Institute Efectividad Clinica y Sanitaria IECS | Villanueva E.,Gestion del Conocimiento Bioetica e Investigaciones | Reveiz L.,Gestion del Conocimiento Bioetica e Investigaciones | Murasaki R.,Centro Latinoamericano Y Del Caribe Of Informacion En Ciencias Of La Salud
Revista Panamericana de Salud Publica/Pan American Journal of Public Health | Year: 2014

Objective. To evaluate the familiarity of the editors of journals indexed in the LILACS database with the guidelines for reporting on and publishing research-promoted by the EQUATOR Network (Enhancing QUAlity and Transparency Of Health Research)-, the journals' requirements for use of the guidelines, and the editors' opinions regarding the reasons for the low rate of use. Methods. LILACS editors were surveyed by e-mail about the guidelines and their availability at the EQUATOR website, and about the requirements and difficulties in using them. Results. Of 802 editors, 16.4% answered the survey. More than half said they were not aware of the guidelines (especially STROBE and PRISMA) and 30% were familiar with the EQUATOR Network. Conclusions. The first Latin American and Caribbean study on LILACS editors' familiarity with the guidelines revealed that more than half of them were not familiar either with the guidelines or the EQUATOR Network.

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