Institute DInvestigacions Biomedics August Pi i Sunyer IDIBAPS

Barcelona, Spain

Institute DInvestigacions Biomedics August Pi i Sunyer IDIBAPS

Barcelona, Spain
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Koutsoudakis G.,University Pompeu Fabra | Koutsoudakis G.,University of Barcelona | De Leon A.P.,University Pompeu Fabra | Herrera C.,Imperial College London | And 10 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2017

A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, the high rate of reinfection within this population calls urgently for novel preventive interventions. In this study, we determined in cell culture and ex vivo experiments with human colorectal tissue that lipoquads, G-quadruplex DNA structures fused to cholesterol, are efficient HCV pangenotypic entry and cell-to-cell transmission inhibitors. Thus, lipoquads may be promising candidates for the development of rectally applied gels to prevent HCV transmission. Copyright © 2017 American Society for Microbiology. All Rights Reserved.

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