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Agnoux A.M.,French National Institute for Agricultural Research | Agnoux A.M.,Institute Des Maladies Of Lappareil Digestif Imad | Antignac J.-P.,French National Institute for Agricultural Research | Boquien C.-Y.,French National Institute for Agricultural Research | And 13 more authors.
Journal of Nutritional Biochemistry | Year: 2015

Perinatal undernutrition affects not only fetal and neonatal growth but also adult health outcome, as suggested by the metabolic imprinting concept. Although maternal milk is the only channel through which nutrients are transferred from mother to offspring during the postnatal period, the impact of maternal undernutrition on milk composition is poorly understood. The present study investigates, in a rat model of nutritional programming, the effects of feeding an isocaloric, low-protein diet throughout gestation and lactation on milk composition and its possible consequences on offspring's growth and metabolic status. We used an integrated methodological approach that combined targeted analyses of macronutrients, free amino acid and fatty acid content throughout lactation, with an untargeted mass-spectrometric-based metabolomic phenotyping. Whereas perinatal dietary protein restriction failed to alter milk protein content, it dramatically decreased the concentration of most free amino acids at the end of lactation. Interestingly, a decrease of several amino acids involved in insulin secretion or gluconeogenesis was observed, suggesting that maternal protein restriction during the perinatal period may impact the insulinotrophic effect of milk, which may, in turn, account for the slower growth of the suckled male offspring. Besides, the decrease in sulfur amino acids may alter redox status in the offspring. Maternal undernutrition was also associated with an increase in milk total fatty acid content, with modifications in their pattern. Altogether, our results show that milk composition is clearly influenced by maternal diet and suggest that alterations in milk composition may play a role in offspring growth and metabolic programming. © 2015 Elsevier Inc.

Duelund-Jakobsen J.,Aarhus University Hospital | Lehur P.-A.,Institute Des Maladies Of Lappareil Digestif Imad | Lundby L.,Aarhus University Hospital | Wyart V.,Institute Des Maladies Of Lappareil Digestif Imad | And 2 more authors.
International Journal of Colorectal Disease | Year: 2016

Introduction: Sacral nerve stimulation (SNS) has been recognised as an effective treatment for faecal incontinence. Many unresolved questions could be answered when comparing large data-series from different centres providing prospective data. Aim: To present data, from an international two-centre SNS prospective database (SNSPD) on functional outcome and management of surgical complications in patients treated with SNS for faecal incontinence. Method: The SNSPD was designed in order to gather detailed pre- and perioperative information followed by a close follow-up in all patients undergoing SNS for bowel dysfunction. The SNSPD was open for inclusion of newly SNS implanted patients in May 2009, and closed on 31 December 2013. Two-centres Aarhus, Denmark, and Nantes, France, included and monitored all patients implanted due to bowel dysfunction according to database criteria. Results: In total, 164 faecal incontinent patients with a median follow-up of 22 (range 1–50) months were implanted. The Wexner incontinence score improved from 15 (range, 3–20) at baseline to 9 (range, 0–20) at latest follow-up (P < 0.001) and VAS impact on daily life improved from 85.5 (range, 3–100) to 20 (range, 0–100) (P < 0.001). Additional surgical intervention was required in 19.5 % during follow-up. Repositioning of the pacemaker due to pain or migration was the most common complication in 12.1 %. Infections leading to explantation occurred in 3.0 %. © 2015, Springer-Verlag Berlin Heidelberg.

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