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Maroga Mboula V.,Ecole des Mines de Nantes | Hequet V.,Ecole des Mines de Nantes | Gru Y.,Institute Departemental Danalyse Et Of Conseil | Colin R.,Institute Departemental Danalyse Et Of Conseil | Andres Y.,Ecole des Mines de Nantes
Journal of Hazardous Materials | Year: 2012

The use of photocatalysis to improve the biodegradability of an antibiotic compound, tetracycline (TC) was investigated. The toxicity of TC and its degradation products were also examined. The Sturm test was conducted to assess the biodegradability of by-products formed in the photocatalytic process. The toxicity of tetracycline and its by-products was evaluated using a dehydrogenase inhibition test, which showed a decrease in toxicity during photocatalysis. However, the Sturm test results indicated that, like tetracycline, the by-products are not biodegradable. Possible structures of these by-products were determined using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). It was found that, during the photocatalytic process, the TC aromatic ring is not opened and the structure of the identified by-products is quite similar to that of tetracycline. A reaction pathway is proposed. © 2012 Elsevier B.V.


Gru Y.,Institute Departemental Danalyse Et Of Conseil | Gru Y.,National Graduate School of Chemistry, Rennes | Colin R.,Institute Departemental Danalyse Et Of Conseil | Le Cloirec P.,National Graduate School of Chemistry, Rennes
Journal of AOAC International | Year: 2010

The effect of analytical conditions on on-line SPE-LC/MS/MS was investigated. Real matrix-induced signal suppression or enhancement due to the ionization process was simulated by using postcolumn introduction experiments. Results were compared with global matrix effects that occur during a routine analysis. Four pesticides were studied: carbendazim, fenuron, thiabendazole, and vamidothion. These compounds have different behaviors in terms of matrix effects. Good correlations were shown, demonstrating that the main matrix effect is due to the ionization step. Good results were also obtained for the RSD values (<5% for routine analysis and <35% for postcolumn introduction).

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